Metabolic Syndrome in Obese and Non-Obese Individuals Presented at A Tertiary Care Hospital of Hyderabad, Pakistan
Metabolic Syndrome in Obese and Non-Obese Individuals
DOI:
https://doi.org/10.54393/pjhs.v5i11.2549Keywords:
Metabolic Syndrome, Obesity, Dyslipidemia, Hypertension, Diabetes MellitusAbstract
Metabolic Syndrome (MetS) has proved to be of enormous negative impact on health of humans, even in case of non-obese people. Objective: To determine the frequency of metabolic syndrome in obese and non-obese individuals at Liaquat University Hospital Hyderabad/Jamshoro. Methods: This Cross sectional comparative study was conducted on 122 persons, 61 obese and 61 non-obese persons, chosen through Non probability consecutive sampling technique. Patients of either gender, aged between 30 to 60 years, visited the OPD or hospitalized were selected. The patients with acute or chronic Ischemic heart disease or stroke, liver, lung or kidney or thyroid diseases or suffering from malignancy along with Pregnant ladies and lactating mothers were excluded. MetS was diagnosed via IDF and AHA classification. Results: Metabolic Syndrome (MetS) was significantly more prevalent in obese individuals (70.5%) than in non-obese individuals (19.7%) (p = 0.001). Obese participants had a higher BMI (29.24 kg/m² versus 20.70 kg/m², p = 0.001), greater prevalence of dyslipidemia (63.9% versus 16.4%, p = 0.001), and uncontrolled diabetes (41.0% versus 13.1%, p = 0.001). Blood pressure was significantly elevated in the obese group, with mean systolic and diastolic pressures of 143.52 mmHg and 93.11 mmHg, respectively (p = 0.001). Conclusion: MetS was present in 45.1% of the participant and was found to be strongly consistent with obesity although it was also detected in noteworthy portion of non-obese persons.
References
Swarup S, Ahmed I, Grigorova Y, Zeltser R. Metabolic syndrome. InStatPearls [internet] 2024 Mar 7. StatPearls Publishing.
Bhalwar R. Metabolic syndrome: The Indian public health perspective. Medical Journal of Armed Forces India. 2020 Jan;76(1):8-16. doi: 10.1016/j.mjafi.2019.12.001.
Krishnamoorthy Y, Rajaa S, Murali S, Sahoo J, Kar SS. Peer Reviewed: Association Between Anthropometric Risk Factors and Metabolic Syndrome Among Adults in India: A Systematic Review and Meta-Analysis of Observational Studies. Preventing Chronic Disease. 2022 May; 19: E24. doi: 10.5888/pcd19.210231.
Adil SO, Islam MA, Musa KI, Shafique K. Prevalence of metabolic syndrome among apparently healthy adult population in Pakistan: a systematic review and meta-analysis. InHealthcare 2023 Feb; 11(4): 531. doi: 10.3390/healthcare11040531.
Das D, Shruthi NR, Banerjee A, Jothimani G, Duttaroy AK, Pathak S. Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies. Frontiers in Nutrition. 2023 Aug 8;10:1221438. doi: 10.3389/fnut.2023.1221438.
Krupp K, Adsul P, Wilcox ML, Srinivas V, Frank E, Srinivas A et al. Prevalence and correlates of metabolic syndrome among rural women in Mysore, India. Indian Heart Journal. 2020 Nov; 72(6): 582-8. doi: 10.1016/j.ihj.2020.09.015.
Vajdi M, Karimi A, Farhangi MA, Ardekani AM. The association between healthy lifestyle score and risk of metabolic syndrome in Iranian adults: a cross-sectional study. BMC Endocrine Disorders. 2023 Jan 17;23(1):16. doi: 10.1186/s12902-023-01270-0.
Liang X, Or B, Tsoi MF, Cheung CL, Cheung BM. Prevalence of metabolic syndrome in the United States National Health and Nutrition Examination Survey 2011–18. Postgraduate Medical Journal. 2023 Sep;99(1175):985-92. https://doi.org/10.1093/postmj/qgad008
Matsha TE, Ismail S, Speelman A, Hon GM, Davids S, Erasmus RT et al. Visceral and subcutaneous adipose tissue association with metabolic syndrome and its components in a South African population. Clinical Nutrition ESPEN. 2019 Aug; 32: 76-81. doi: 10.1016/j.clnesp.2019.04.010.
Shah RV, Murthy VL, Abbasi SA, Blankstein R, Kwong RY, Goldfine AB et al. Visceral adiposity and the risk of metabolic syndrome across body mass index: the MESA Study. JACC: Cardiovascular Imaging. 2014 Dec; 7(12): 1221-35. doi: 10.1016/j.jcmg.2014.07.017.
Lee A, Kim YJ, Oh SW, Lee CM, Choi HC, Joh HK et al. Cut-off values for visceral fat area identifying korean adults at risk for metabolic syndrome. Korean Journal of Family Medicine. 2018 Jul; 39(4): 239. doi: 10.4082/kjfm.17.0099.
Sigit FS, Tahapary DL, Trompet S, Sartono E, Willems van Dijk K, Rosendaal FR et al. The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies. Diabetology & Metabolic Syndrome. 2020 Dec; 12: 1-1. doi: 10.1186/s13098-019-0503-1.
Grewal RS, Hancock A, Yang A, Kalyani RR. Obesity and Metabolic Syndrome in South Asians. Metabolic Syndrome: A Comprehensive Textbook. 2024 Jan 31:81-101. https://doi.org/10.1007/978-3-319-12125-3_52-1
Jha BK, Sherpa ML, Imran M, Mohammed Y, Jha LA, Paudel KR, et al.. Progress in Understanding Metabolic Syndrome and Knowledge of Its Complex Pathophysiology. Diabetology. 2023 Apr 12;4(2):134-59. https://doi.org/10.3390/diabetology4020015
Goswami B, Reang T, Sarkar S, Sengupta S, Bhattacharjee B. Role of body visceral fat in hypertension and dyslipidemia among the diabetic and nondiabetic ethnic population of Tripura-A comparative study. Journal of Family Medicine and Primary Care. 2020 Jun; 9(6): 2885-90. doi: 10.4103/jfmpc.jfmpc_187_20.
Ishihara T, Watanabe M, Tanaka K, Nakamura K. Association of visceral adiposity with hypertension, dyslipidemia, and type 2 diabetes: a cross-sectional study among Japanese men and women. Kitasato Medical Journal. 2011 Mar; 41: 10-8.
Shi TH, Wang B, Natarajan S. The influence of metabolic syndrome in predicting mortality risk among US adults: importance of metabolic syndrome even in adults with normal weight. Preventing Chronic Disease. 2020 May; 17: E36. doi: 10.5888/pcd17.200020.
Park NH, Kang YE, Yoon JH, Ahn YC, Lee EJ, Park BJ, et al. Comparative study for fatigue prevalence in subjects with diseases: a systematic review and meta-analysis. Scientific Reports. 2024 Oct 7;14(1):23348. https://doi.org/10.1038/s41598-024-74683-z
Cheang C, Law S, Ren J, Chan W, Wang C, Dong Z. Prevalence of hyperuricemia in patients with severe obesity and the relationship between serum uric acid and severe obesity: A decade retrospective cross-section study in Chinese adults. Frontiers in Public Health. 2022 Aug 26;10:986954. doi: 10.3389/fpubh.2022.986954.
Piuri G, Zocchi M, Della Porta M, Ficara V, Manoni M, Zuccotti GV et al. Magnesium in obesity, metabolic syndrome, and type 2 diabetes. Nutrients. 2021 Jan; 13(2): 320. doi: 10.3390/nu13020320.
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