Association of Age and Gender with Early Onset Seizures in Patients of Acute Ischemic Stroke at a Tertiary Care Setting: Age and Gender with Early Onset Seizures

Rekha Kumari; Atif Ahmed; Ramesh Kumar Suthar; Kuldeep Kumar Poorani; Ali Akbar Nangraj; Kashif Ali

doi:10.54393/pjhs.v6i4.2436

Authors

Rekha Kumari Department of Neurology, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Atif Ahmed Department of Medicine, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Ramesh Kumar Suthar Department of Medicine, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Kuldeep Kumar Poorani Department of Medicine, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Ali Akbar Nangraj Department of Medicine, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Kashif Ali Department of Medicine, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i4.2436

Keywords:

Ischemic Stroke, Early Seizures, Gender, Age, Post-Stroke Epilepsy

Abstract

The prevalence of ischemic stroke is more in south Asian countries. Individuals having an early seizure have a significantly elevated chance of developing epilepsy after stroke than individuals having stroke but no early seizure. The seizures that occur following the stroke has been observed as contributing to more worse outcomes and disabilities. Objective: To determine the association of age and gender with earliest inception seizures in sufferers of acute ischemic stroke at a tertiary care setting in Sindh Pakistan. Methods: This cross sectional study was organized at Department of Medicine of Bilawal Medical College Hospital, Kotri from 26 May 2023 to 26 October 2023. In this study, the patients attending Bilawal Medical College Hospital reporting with stroke were recruited for this research study. The presence or absence of earliest seizures is dependent variable while, the age, gender and sociodemographic status are variables in present study. The data were analyzed on International Bussiness Machine Statistical Package for Social Sciences Version 26.0. Results: Out of 118 stroke patients, 17 (14.4%) found with early seizures. The gender and age appeared to have significant association with early onset of seizures with p value 0.01 and 0.04 correspondingly. Conclusions: It was concluded that male patients and all patients aged between 51 to 60 years were more likely to experience an early seizure. After an acute stroke, earliest seizures could not resemble to unfavorable functional prognosis.

Author Biography

Kuldeep Kumar Poorani, Department of Medicine, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

References

Chen J, Ye H, Zhang J, Li A, Ni Y. Pathogenesis of seizures and epilepsy after stroke. Acta Epileptologica. 2022 Dec; 4: 1-6. doi: 10.1186/s42494-021-00068-8.

Zelano J, Holtkamp M, Agarwal N, Lattanzi S, Trinka E, Brigo F. How to diagnose and treat post-stroke seizures and epilepsy. Epileptic Disorders. 2020 Jan; 22(3): 252-63. doi: 10.1684/epd.2020.1159.

Shubham M, Scott E, Kasner J, Dawson T, Tanaka Y, Zhao HP et al. Outcomes in Patients with Poststroke Seizures. Journal of the American Medical Association Neurology. 2023 Nov; 80: 1155. doi: 10.1001/jamaneurol.2023.3240.

Herpich F and Rincon F. Management of acute ischemic stroke. Critical Care Medicine. 2020 Nov; 48(11): 1654-63. doi: 10.1097/CCM.0000000000004597.

Gunarathne A, Patel JV, Gammon B, Gill PS, Hughes EA, Lip GY. Ischemic stroke in South Asians: a review of the epidemiology, pathophysiology, and ethnicity-related clinical features. Stroke. 2009 Jun; 40(6): e415-23. doi: 10.1161/STROKEAHA.108.535724.

Federico EM, Carroll K, McGrath M, Walker M, Stafstrom I, Skinner E et al. Incidence and risk factors of post-stroke seizure among ischemic stroke patients. Journal of Stroke and Cerebrovascular Diseases. 2024 Dec; 33(12): 108072. doi: 10.1016/j.jstrokecerebrovasdis.2024.108072.

Mohamed AA, Tan JK, Tan MM, Khoo CS, Wan Yahya WN, Abd Rahman MS et al. Risk Factors for Post-Stroke Seizures in a Tertiary Care Center: A Case-Control Study. Neuropsychiatric Disease and Treatment. 2024 Dec: 1615-28. doi: 10.2147/NDT.S473483.

Qazi TR, Siddiqui AI, Lakhair MA, Mahesar SA. Frequency of early seizures in patients of acute ischemic stroke. Seizure. 2016 Jul; 1(7): 3-59.

Kim HJ, Park KD, Choi KG, Lee HW. Clinical predictors of seizure recurrence after the first post-ischemic stroke seizure. BioMed Central Neurology. 2016 Dec; 16: 1-0. doi: 10.1186/s12883-016-0729-6.

Mohamed AT, El Rakawy MH, Abdelhamid YA, Hazzou AM, Wahid el din MM. Stroke-related early seizures: clinical and neurophysiological study in a sample of Egyptian population. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery. 2023 Jan; 59(1): 3. doi: 10.1186/s41983-022-00603-5.

Burneo JG, Fang J, Saposnik G. Investigators of the Registry of the Canadian Stroke Network. Impact of seizures on morbidity and mortality after stroke: a Canadian multi‐centre cohort study. European Journal of Neurology. 2010 Jan; 17(1): 52-8. doi: 10.1111/j.1468-1331.2009.02739.x.

Ma S, Fan X, Zhao X, Wang K, Wang H, Yang Y. Risk factors for early-onset seizures after stroke: A systematicreview and meta‐analysis of 18 observational studies. Brain and Behavior. 2021 Jun; 11(6): e02142. doi: 10.1002/brb3.2142.

Thomas R. Early Post-stroke Seizures in Acute Ischaemic Stroke: A Retrospective Study. Journal of Clinical & Diagnostic Research. 2023 May; 17(5). doi: 10.7860/JCDR/2023/63169.17821.

Mohamed C and Kissani N. Early seizures in acute stroke. Pan African Medical Journal. 2015 Feb; 20(1). doi: 10.11604/pamj.2015.20.136.5925.

Xu MY. Poststroke seizure: optimising its management. Stroke and Vascular Neurology. 2019 Mar; 4(1). doi 10.1136/svn-2018-000175.

Carroll K, Federico E, Stafstrom I, Skinner E, Maraghe M, Levitt M. E-030 Incidence and risk factors for new seizure after ischemic stroke in a single institution series. Journal of Stroke and Cerebrovascular Diseases. 2024 Dec; 33(12): 108072. doi: 10.1016/j.jstrokecerebrovasdis.2024.108072.

Alsaad F, Alkeneetir N, Almatroudi M, Alatawi A, Alotaibi A, Aldibasi O et al. Early seizures in stroke-frequency, risk factors, and effect on patient outcomes in a tertiary center in Saudi Arabia. Neurosciences Journal. 2022 Apr; 27(2): 104-10. doi 10.17712/nsj.2022.2.20210144.

Shariff E, Nazish S, Zafar A, Shahid R, Aljaafari D, Soltan NM et al. Characteristics of Stroke-related Seizures and their Predictive Factors: A Tertiary Care Center Experience. Annals of African Medicine. 2024 Jul; 23(3): 285-90. doi: 10.4103/aam.aam_15_23.

Wali ZA, Azam N, Farooq H, Arif M, Rafiq U, Zahid M. Prevalence of Early Seizures in Acute Stroke Patients: Prevalence of Early Seizures in Acute Stroke Patients. Pakistan Journal of Health Sciences. 2024 Sep; 5(9): 194-7. doi: 10.54393/pjhs.v5i09.2004.

Nguyen MT, Sakamoto Y, Maeda T, Woodward M, Anderson CS, Catiwa J et al. Influence of Socioeconomic Status on Functional Outcomes After Stroke: A Systematic Review and Meta‐Analysis. Journal of the American Heart Association. 2024 May; 13(9): e033078. doi: 10.1161/JAHA.123.033078.