Therapeutic Effect of Magnesium Supplementation in Improving Quality of Life among Elderly Insomniac Participants

Effect of Magnesium Supplementation in Improving QoL

Authors

  • Amna Liaqat University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan
  • Bahisht Rizwan University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Ayesha Amjad University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan/Combined Military Hospital, Rawalpindi, Pakistan
  • Zunaira Rasool University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v4i09.995

Keywords:

Insomnia, Leeds Sleep Evaluation Questionnaire, Quality of Sleep, Serum Magnesium, Magnesium Supplementation

Abstract

Insomnia is increasing day by day, according to global prevalence it ranges from10%to40%with trouble falling asleep, remaining asleep, or having non-restorative sleep that is accompanied by daytime impairment or distress. Magnesium seems to play a key role in there gelation of sleep. Objective: To compare the therapeutic effect of magnesium supplementation in improving quality of life among elderly insomniac participants with control and treatment group. Methods: The study design was double blind randomized clinical trial. Purposive sampling technique was used to allocate gender elderly people. Data were collected from Al-Saida Shuhda old age home, Lahore and the participants were divided into two groups, 40 participants in each group. Group 0 (control group) were given regular diet without magnesium supplement for 8 weeks. Group 1 (treatment group were given Magnesium supplements (500mg) for 8 weeks. Data were tabulated and analyzed with the help of SPSS 25.0. Results: The results shown that the magnesium supplementation had highly significant results in improving LSEQ, serum magnesium, serum melatonin, serum cortisol and serum renin level without showing any side effects. Group 0 has shown 0.152 (GTS), 0.088(QOS), 0.168(AFS), 0.195(BFW), 0.292(serum Mg), 0.567(serum melatonin), 0.276(serum cortisol), 0.101(serum renin) whereas group 1 has shown 0.01(GTS), 0.01(QOS), 0.003(AFS) and 0.03(BFW), 0.02(serum Mg), 0.01(serum melatonin), 0.02(serum cortisol), 0.02(serum renin), respectively. Conclusions: It was concluded from the results that magnesium supplementation in elderly people has highly significant effects in improving insomnia and quality of sleep.

References

Roth T. Sleep duration, insomnia and longevity. Sleep Medicine. 2009 Dec; 10(10): 1071-2. doi: 10.1016/j.sleep.2009.04.004. DOI: https://doi.org/10.1016/j.sleep.2009.04.004

Krystal AD. The effect of insomnia definitions, terminology, and classifications on clinical practice. Journal of the American Geriatrics Society. 2005 Jul; 53(S7): S258-63. doi: 10.1111/j.1532-5415.2005.53391.x. DOI: https://doi.org/10.1111/j.1532-5415.2005.53391.x

Kyle SD, Morgan K, Espie CA. Insomnia and health-related quality of life. Sleep Medicine Reviews. 2010 Feb; 14(1): 69-82. doi: 10.1016/j.smrv.2009.07.004. DOI: https://doi.org/10.1016/j.smrv.2009.07.004

Umar A, Khan MS, Sehgal SA, Jafar K, Ahmad S, Waheed A, et al. Epidemiological studies of sleep disorder in educational community of Pakistani population, its major risk factors and associated diseases. PloS One. 2022 Apr; 17(4): e0266739. doi: 10.1371/journal.pone.0266739. DOI: https://doi.org/10.1371/journal.pone.0266739

St-Onge MP, Mikic A, Pietrolungo CE. Effects of diet on sleep quality. Advances in Nutrition. 2016 Sep; 7(5): 938-49. doi: 10.3945/an.116.012336. DOI: https://doi.org/10.3945/an.116.012336

Arab A, Rafie N, Amani R, Shirani F. The role of magnesium in sleep health: a systematic review of available literature. Biological Trace Element Research. 2023 Jan; 201(1): 121-8. doi: 10.1007/s12011-022-03162-1. DOI: https://doi.org/10.1007/s12011-022-03162-1

Ranade VV and Somberg JC. Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans. American Journal of Therapeutics. 2001 Sep; 8(5): 345-57. DOI: https://doi.org/10.1097/00045391-200109000-00008

Jahnen-Dechent W and Ketteler M. Magnesium basics. Clinical Kidney Journal. 2012 Feb; 5(Suppl_1): i3-14. doi: 10.1093/ndtplus/sfr163. DOI: https://doi.org/10.1093/ndtplus/sfr163

Fox C, Ramsoomair D, Carter C. Magnesium: its proven and potential clinical significance. Southern Medical Journal. 2001 Dec; 94(12): 1195-202. doi: 10.1253/circj.CJ-10-1021. DOI: https://doi.org/10.1097/00007611-200194120-00014

Olza J, Aranceta-Bartrina J, González-Gross M, Ortega RM, Serra-Majem L, Varela-Moreiras G, et al. Reported dietary intake, disparity between the reported consumption and the level needed for adequacy and food sources of calcium, phosphorus, magnesium and vitamin D in the Spanish population: findings from the ANIBES study. Nutrients. 2017 Feb; 9(2): 168. doi: 10.3390/nu9020168. DOI: https://doi.org/10.3390/nu9020168

Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015 Sep; 7(9): 8199-226. doi: 10.3390/nu7095388. DOI: https://doi.org/10.3390/nu7095388

Schwalfenberg GK and Genuis SJ. The importance of magnesium in clinical healthcare. Scientifica. 2017 Oct; 2017: 4179326. doi: 10.1155/2017/4179326. DOI: https://doi.org/10.1155/2017/4179326

Nielsen FH. Relation between magnesium deficiency and sleep disorders and associated pathological changes. In: Modulation of Sleep by Obesity, Diabetes, Age, and Diet. 2015 Jan: 291-6. Academic Press. doi: 10.1016/B978-0-12-420168-2.00031-4. DOI: https://doi.org/10.1016/B978-0-12-420168-2.00031-4

Kim I, Choi H, Kim B. Psychometric properties of Korean version of modified Leeds sleep evaluation questionnaire (KMLSEQ). Korean Journal of Rehabilitation Nursing. 2014 Jun; 17(1):10- 7. doi: 10.7587/kjrehn.2014.10. DOI: https://doi.org/10.7587/kjrehn.2014.10

Cricco M, Simonsick EM, Foley DJ. The impact of insomnia on cognitive functioning in older adults. Journal of the American Geriatrics Society. 2001 Sep; 49(9): 1185-9. doi: 10.1046/j.1532-5415.2001.49235.x. DOI: https://doi.org/10.1046/j.1532-5415.2001.49235.x

Dangol M, Shrestha S, Rai Koirala SK. Insomnia and its associated factors among older people of selected ward of Banepa municipality, Nepal. Nursing Open. 2020 Jan; 7(1): 355-63. doi: 10.1002/nop2.396. DOI: https://doi.org/10.1002/nop2.396

Choi H, Kim S, Kim B, Kim I. Psychometric properties of the Korean versions of three sleep evaluation questionnaires. Clinical Nursing Research. 2015 Oct; 24(5): 526-38. doi: 10.1177/1054773814549827. DOI: https://doi.org/10.1177/1054773814549827

Stevens N, Dorsett J, DaBell A, Eggett DL, Han X, Parker TL. Subjective assessment of the effects of an herbal supplement containing lavender essential oil on sleep quality: A randomized, double-blind, placebo-controlled crossover study. Cogent Medicine. 2017 Jan; 4(1): 1380871. doi: 10.1080/2331205X.2017.1380871. DOI: https://doi.org/10.1080/2331205X.2017.1380871

Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences. 2012 Dec; 17(12): 1161.

Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnesium research. 2008 Dec; 21(4): 218-23. doi: 10.1684/mrh.2008.0149.

Haddad S, Leitman SF, Wesley RA, Cecco S, Yau YY, Starling J, et al. Placebo‐controlled study of intravenous magnesium supplementation during large‐volume leukapheresis in healthy allogeneic donors. Transfusion. 2005 Jun; 45(6): 934-44. doi: 10.1111/j.1537-2995.2005.04312.x. DOI: https://doi.org/10.1111/j.1537-2995.2005.04312.x

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Published

2023-09-30
CITATION
DOI: 10.54393/pjhs.v4i09.995
Published: 2023-09-30

How to Cite

Liaqat, A., Rizwan, B., Amjad, A., & Rasool, Z. (2023). Therapeutic Effect of Magnesium Supplementation in Improving Quality of Life among Elderly Insomniac Participants: Effect of Magnesium Supplementation in Improving QoL. Pakistan Journal of Health Sciences, 4(09), 119–124. https://doi.org/10.54393/pjhs.v4i09.995

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