Novel Approaches for Treatment of Epilepsy: Treatment of Epilepsy

Muhammad Ahsan  Waqar; Mehak  Saleem; Tooba  Mehboob; Naila  Tabassam; Dawood  Ilyas; Muhammad Sajid  Nawaz; Mahnoor  Foaad; Maria  Riaz; Aimon  Qureshi; Muhammad  Waqas

doi:10.54393/pjhs.v4i08.971

Authors

Muhammad Ahsan Waqar Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan
Mehak Saleem Children’s Hospital, Lahore, Pakistan
Tooba Mehboob Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan
Naila Tabassam Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan
Dawood Ilyas School of Applied Sciences, University of Huddersfield, West Yorkshire, United Kingdom
Muhammad Sajid Nawaz Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan
Mahnoor Foaad Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan
Maria Riaz Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan
Aimon Qureshi Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan
Muhammad Waqas Faculty of Pharmaceutical Sciences, University of Central Punjab, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v4i08.971

Keywords:

Epilepsy, Corpus Callostomy, Neurostimulation, Surgery

Abstract

Epilepsy is a serious neurological disorder on the juncture of psychiatry and neurology. It is characterized by recurrent and episodic seizures which are due to excessive discharge by the brain neurons. The therapeutic response failure of more than one or two antiepileptic drugs (AEDs) is the benchmark of refractory or intractable epilepsy. The aim of the study was to determine new approaches which lead towards the treatment of epilepsy. In order to treat focal mesial temporal lobe epilepsy or neocortical epilepsy in adults and any malformation of cortical development such as focal dysplasia surgical resection remains the gold standard treatment. Disconnection procedures such as corpus callosotomy and multiple subpial transections are the best alternative treatment for that patient whose seizure origin is in eloquent cortex or having generalized epilepsy syndromes. Palliative neuromodulation procedures such as Vagus nerve stimulation (VNS), Responsive neurostimulation (RNS) and Deep brain stimulation (DBS) are best approach to treat intractable epileptic patients who are not suitable candidates of surgery. As the search of better management of epilepsy continues gene therapy and optogenetics gain a momentum in neuroscience.

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