Correlation between Vitamin D Deficiency and Osteopenia in Women Residing in Karachi, Pakistan  : Vitamin D Deficiency and Osteopenia in Women

Yameen Bocha; Anita Haroon; Benish Zafar; Kahkashan Perveen; Naheed Akhtar; Padma Rathore; Saher Mushtaque

doi:10.54393/pjhs.v6i6.3073

Authors

Yameen Bocha Department of Medicine, Sindh Govt Lyari General Hospital, Karachi, Pakistan
Anita Haroon Department of Medicine, Hamdard University Hospital, Karachi, Pakistan
Benish Zafar Department: Biochemistry, Baqai Medical University, Karachi, Pakistan
Kahkashan Perveen Department: Biochemistry, Baqai Medical University, Karachi, Pakistan
Naheed Akhtar Department of Anatomy, Karachi Institute of Medical Sciences, Combined Military Hospital, Karachi, Pakistan
Padma Rathore Department of Physiology, Jinnah Sindh Medical University, Karachi, Pakistan
Saher Mushtaque Department of Community Dentistry, Sir Syed College of Medical Sciences, Karachi, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i6.3073

Keywords:

Osteopenia, Pakistan, Women, Vitamin D

Abstract

Osteopenia is one of the primary health concerns among Pakistani women. Objective: To assess the Correlation Between Vitamin D Deficiency and Osteopenia in Women in Karachi, Pakistan. Methods: A cross-sectional survey was conducted among 200 women in Karachi, Pakistan. A self-reported questionnaire was given to all participants so that they could fill in the demographic data. Only participants who were willing to participate in the study were included, and those who failed to provide any data regarding the status of menopause were excluded. SPSS version 23.0 was used to analyze the data. Results: The 200 women in the study had a high reproductive burden (mean pregnancies = 12), with a mean age of 65.2 years and a BMI of 25.6 kg/m². Age-related decreases in bone mineral density were significant (p=0.0002), and osteoporosis was most prevalent in older age groups. The distribution of vitamin D deficiency across age groups was not statistically significant (p=0.22), but it was associated with ageing (p=0.011). Conclusions: It was concluded that although vitamin D deficiency is common among women, age is a better indicator of deteriorating bone mineral density. Age-focused bone health interventions are needed, as osteoporosis and osteopenia were significantly correlated with advancing age.

References

Fan Y, Li Q, Liu Y, Miao J, Zhao T, Cai J et al. Sex-and Age-Specific Prevalence of Osteopenia and Osteoporosis: Sampling Survey. Journal of Medical Internet Research Public Health and Surveillance. 2024 Apr; 10(1): e48947. doi: 10.2196/48947.

Nazir S, Sagheer U, Riaz S, Khan ZM. Frequency of Osteoporosis and Osteopenia and its associated factors among general population in Faisalabad. The Professional Medical Journal. 2019 Dec; 26(12): 2216-21. doi: 10.29309/TPMJ/2019.26.12.4073.

Varacallo M, Seaman TJ, Jandu JS, Pizzutillo P. Osteopenia. 2023 Aug.

Vierucci F, Del Pistoia M, Fanos M, Erba P, Saggese G. Prevalence of hypovitaminosis D and predictors of vitamin D status in Italian healthy adolescents. Italian Journal of Pediatrics. 2014 Dec; 40: 1-9. doi: 10.1186/1824-7288-40-54.

Zhang L, Luo X, Liu H, Zhu W, Zhang X, Zhu S et al. Prevalence and risk factors of osteoporosis and osteopenia among residents in Hubei province, China. Archives of Osteoporosis. 2023 Apr; 18(1): 49. doi: 10.1007/s11657-023-01245-7.

Lin X, Guo H, Lian Y, Kou J, Wang G, Chen Y et al. Osteoporosis and related health status among the elderly urban residents in elderly-care inns in Beijing, a multicenter DXA survey. Frontiers in Endocrinology. 2022 Jul; 13: 875678. doi: 10.3389/fendo.2022.875678.

Xiao PL, Cui AY, Hsu CJ, Peng R, Jiang N, Xu XH et al. Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis. Osteoporosis International. 2022 Oct; 33(10): 2137-53. doi: 10.1007/s00198-022-06454-3.

Shen Y, Huang X, Wu J, Lin X, Zhou X, Zhu Z et al. The global burden of osteoporosis, low bone mass, and its related fracture in 204 countries and territories, 1990-2019. Frontiers in Endocrinology.2022 May; 13: 882241. doi: 10.3389/fendo.2022.882241.

De Sire A, Gallelli L, Marotta N, Lippi L, Fusco N, Calafiore D et al. Vitamin D deficiency in women with breast cancer: a correlation with osteoporosis? A machine learning approach with multiple factor analysis. Nutrients. 2022 Apr; 14(8): 1586. doi: 10.3390/nu14081586.

Grili PP, Vidigal CV, Cruz GF, Albergaria BH, Marques-Rocha JL, Pereira TS et al. Nutrient patterns and risk of osteopenia in postmenopausal women. Nutrients. 2023 Mar; 15(7): 1670. doi: 10.3390/nu15071670.

Chadgal S and Talwar I. Prevalence of osteopenia and osteoporosis among young adult girls residing in the hostels of Panjab University, Chandigarh. Prevalence. 2017 Nov; 2(6).

Gupta P, Dabas A, Seth A, Bhatia VL, Khadgawat R, Kumar P et al. Indian Academy of Pediatrics Revised (2021) guidelines on prevention and treatment of vitamin D deficiency and rickets. Indian Pediatrics. 2022 Feb; 59(2): 142-58. doi: 10.1007/s13312-022-2448-y.

Zahid S, Hanif A, Faridi TA, Masood Z, John A. Frequency of Osteopenia and its association with dietary factors among female population aged 18-60 years: Osteopenia and its association with dietary factors. Diet Factor (Journal of Nutritional and Food Sciences). 2020; 01(02): 48-52. doi: 10.54393/df.v1i02.2.

De Martinis M, Allegra A, Sirufo MM, Tonacci A, Pioggia G, Raggiunti M et al. Vitamin D deficiency, osteoporosis and effect on autoimmune diseases and hematopoiesis: a review. International Journal of Molecular Sciences. 2021 Aug; 22(16): 8855. doi: 10.3390/ijms22168855.

Chen JH, Chen YC, Tsai MK, Chiou JM, Lee WC, Tsao CK, Tsai KS, Chie WC. Predicting the risk of osteopenia for women aged 40–55 years. Journal of the Formosan Medical Association. 2017 Nov; 116(11): 888-96. doi: 10.1016/j.jfma.2017.01.003.

Khan AH, Iqbal R, Naureen G, Dar FJ, Ahmed FN. Prevalence of vitamin D deficiency and its correlates: results of a community-based study conducted in Karachi, Pakistan. Archives of Osteoporosis. 2012 Dec; 7: 275-82. doi: 10.1007/s11657-012-0108-x.

Haq AA, Memon I, Mahmood N, Shah FR, Malik F. Prevalence of osteopenia and osteoporosis in women using dual energy x-ray absorptiometry scan. Pakistan Journal of Physiology. 2021 Jun; 17(2): 27-30. doi: 10.69656/pjp.v17i2.1316.

Tang G, Feng L, Pei Y, Gu Z, Chen T, Feng Z. Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women. Frontiers in Endocrinology. 2023 Oct; 14: 1154927. doi: 10.3389/fendo.2023.1154927.

van Schoor N, de Jongh R, Lips P. Worldwide vitamin D status. Feldman and Pike's Vitamin D. 2024 Jan: 47-75. doi: 10.1016/B978-0-323-91338-6.00004-5.

Min C, Yoo DM, Wee JH, Lee HJ, Choi HG. High-intensity physical activity with high serum vitamin D levels is associated with a low prevalence of osteopenia and osteoporosis: A population-based study. Osteoporosis International. 2021 May; 32: 883-91. doi: 10.1007/s00198-020-05746-w.

Shamsi U, Azam I, Shamsi A, Shamsi D, Callen D. Frequency and determinants of vitamin D deficiency among premenopausal and postmenopausal women in Karachi Pakistan. BioMed Central Women's Health. 2021 May; 21(1): 194. doi: 10.1186/s12905-021-01339-9.