The Role of Nanomaterials in Preventive Dentistry: Antimicrobial Coatings for Dental Restorations
Nanomaterials in Preventive Dentistry: Antimicrobial Coatings
DOI:
https://doi.org/10.54393/pjhs.v5i11.2366Keywords:
Nanocomposites, Anti-Microbial Coatings, Dental Restorations, BiocompatibilityAbstract
The applicability of antimicrobial nanomaterial coatings in preventive dentistry such as dental restoration practice in combating dental caries while embracing biocompatibility, and long-lasting and low bacterial adhesion properties has been the main area of research for many decades. Objective: To review the role of different types of nanomaterials in the field of preventive dentistry by focussing on anti-microbial coatings for dental restorations. Methods: The articles were taken from PubMed, Science Direct, and Google Scholar within the years 2018-2024 following PISMA 2020 guidelines. The effectiveness of nanomaterials included in dental coatings in terms of antimicrobial properties, biocompatibility, and durability in clinical applications was observed. Bacterial adhesion, caries prevention, material nanotechnology, and patient satisfaction were assessed. The antimicrobial efficiency and restorative outcomes of different nanomaterials: via silver, zinc oxide and titanium dioxide; were evaluated. Initially, 109 articles were retrieved, which were then screened based on predefined inclusion and exclusion, resulting in 16 studies for detailed analysis. The regions of study conduction were North America, Europe and Asia. Results: The antimicrobial efficacy of nano-coatings in dental restorations was seen via reduced bacterial adhesion and biofilm. The link between nanomaterials like silver nanoparticles and titanium dioxide enhanced secondary caries prevention and improved the long-term stability of restorative materials. Biocompatibility studies demonstrated that these coatings are biocompatible; however, more work is required. The application of antimicrobial nano-coatings gives adaptive and therapeutic characteristics. Conclusions: It was concluded that nanotechnology should lead to better durability and performance of dental restorations thus better oral health and less caries
References
Rattan S, Fawcett D, Tennant M, Granich J, Poinern G. Progress of Nanomaterials in Preventative and Restorative Dentistry. Recent Progress in Materials. 2021 Mar; 3(1): 1-42. doi: 10.21926/rpm.2101007.
Zhang S, Lin L, Huang X, Lu YG, Zheng DL, Feng Y. Antimicrobial Properties of Metal Nanoparticles and Their Oxide Materials and Their Applications in Oral Biology. Journal of Nanomaterials. 2022; 2022(1): 2063265. doi: 10.1155/2022/2063265.
Kaviya NE, Somasundaram DJ, Roy DA. Advancement in Nanotechnology for Restorative Dentistry. European Journal of Molecular and Clinical Medicine. 2020 Dec; 7(1): 3295-306.
Sebold M, André CB, Sahadi BO, Breschi L, Giannini M. Chronological History and Current Advancements of Dental Adhesive Systems Development: A Narrative Review. Journal of Adhesion Science and Technology. 2021 Sep; 35(18): 1941-67. doi: 10.1080/01694243.2020.1865611.
Kanathila H, Pangi AM, Patil S, Shirlal S, Jaiswal R. An Insight into Various Metallic Oxide Nanoparticles as Antimicrobials and Their Applications in Dentistry. Journal of Evolution of Medical and Dental Sciences. 2021 Aug; 10(33): 2803-9. doi: 10.14260/jemds/2021/572.
Song W and Ge S. Application of Antimicrobial Nanoparticles in Dentistry. Molecules. 2019 Mar; 24(6): 1033. doi: 10.3390/molecules24061033.
Liu Y, Yang J, Yang Y, Li M, Xu HH, Weir MD et al. Evaluation of the Ability of Adhesives with Antibacterial and Remineralization Functions to Prevent Secondary Caries in Vivo. Clinical Oral Investigations. 2022 Apr; 26(4): 3637-50. doi: 10.1007/s00784-021-04334-4.
Ameli N, Asadi S, Ghorbani R, Mohebi S, Hans M. Comparative Antibacterial Efficacy of Orthodontic Brackets Coated with Titanium Dioxide, Copper Oxide, and Hydroxyapatite-Silver Nanoparticles Against Streptococcus Mutans. Middle East Journal of Rehabilitation and Health Studies. 2022; 9(1). doi: 10.5812/mejrh.119536.
Hashem R, Ghobashy S, Abdel Hamid Z. The Efficacy of Nano-silver Coated Stainless Steel Brackets in Prevention of Enamel Demineralization in Orthodontic Patients. Al-Azhar Journal of Dental Science. 2022 Oct; 25(4): 495-504. doi: 10.21608/ajdsm.2022.129243.1328.
Duraisamy S, Anandan N, Kannan R. Evaluation of Antibacterial Effect of Hybrid Nano-coating of Stainless Steel Orthodontic Brackets on Streptococcus Mutans–An in vitro Study. Journal of Pharmacy and Bio-allied Sciences. 2024 Apr; 16(Suppl 2): S1784-91. doi: 10.4103/jpbs.jpbs_1190_23.
Fan M, Yang J, Xu HH, Weir MD, Tao S, Yu Z et al. Remineralization Effectiveness of Adhesive Containing Amorphous Calcium Phosphate Nanoparticles On Artificial Initial Enamel Caries in A Biofilm-Challenged Environment. Clinical Oral Investigations. 2021 Sep; 25(9): 5375-90. doi: 10.1007/s00784-021-03846-3.
Mokeem L, Balhaddad AA, Garcia IM, Collares FM, Melo MA. Nanoparticle-based Antimicrobial for Dental Restorative Materials. In Emerging Nanomaterials and Nano-Based Drug Delivery Approaches to Combat Antimicrobial Resistance. 2022 Jan: pp. 661-700. doi: 10.1016/B978-0-323-90792-7.00013-0.
Kazemi M, Navarchian AH, Ahangaran F. Effects of Silica Surface Modification with Silane and Poly (Ethylene Glycol) On Flexural Strength, Protein-Repellent, And Antibacterial Properties of Acrylic Dental Nanocomposites. Dental Materials. 2023 Oct; 39(10): 863-71. doi: 10.1016/j.dental.2023.07.010.
Zhu T, Huang Z, Shu X, Zhang C, Dong Z, Peng Q. Functional Nanomaterials and Their Potentials in Antibacterial Treatment of Dental Caries. Colloids and Surfaces B: Biointerfaces. 2022 Oct; 218: 112761. doi: 10.1016/j.colsurfb.2022.112761.
Siva S, Kishore S, Gopinath A. A Systematic Review on Nano Coated Orthodontic Brackets and its Antibacterial Effects. Journal of Clinical and Diagnostic Research. 2022 Feb; 16(2): ZE18-22. doi: 10.7860/JCDR/2022/52649.16020.
Ferrando-Magraner E, Bellot-Arcís C, Paredes-Gallardo V, Almerich-Silla JM, García-Sanz V, Fernández-Alonso M et al. Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis. Medicina. 2020 Jan; 56(2)55. doi: 10.3390/medicina56020055.
Pérez-Castro B, Flores-Ledesma A, Rubio-Rosas E, Teutle-Coyotecatl B, Flores-Ferreyra BI, Argueta-Figueroa L et al. Comparison of the Physical Properties of Glass Ionomer Modified with Silver Phosphate/Hydroxyapatite or Titanium Dioxide Nanoparticles: in Vitro Study. The Journal of Clinical Pediatric Dentistry. 2024 Jul; 48(4): 160-7. doi: 10.22514/jocpd.2024.089.
Kim YJ, Choe YE, Shin SJ, Park JH, Dashnyam K, Kim HS et al. Photocatalytic Effect-Assisted Antimicrobial Activities of Acrylic Resin Incorporating Zinc Oxide Nano-flakes. Biomaterials Advances. 2022 Aug; 139: 213025. doi: 10.1016/j.bioadv.2022.213025.
Balhaddad AA, Ibrahim MS, Weir MD, Xu HH, Melo MA. Concentration Dependence of Quaternary Ammonium Monomer On the Design of High-Performance Bioactive Composite for Root Caries Restorations. Dental Materials. 2020 Aug; 36(8): e266-78. doi: 10.1016/j.dental.2020.05.009.
Fan M, Li M, Yang Y, Weir MD, Liu Y, Zhou X et al. Dual-functional Adhesive Containing Amorphous Calcium Phosphate Nanoparticles and Dimethyl Amino-hexadecyl Methacrylate Promoted Enamel Remineralization in A Biofilm-Challenged Environment. Dental Materials. 2022 Sep; 38(9): 1518-31. doi: 10.1016/j.dental.2022.07.003.
D'Agostino A, Bertolini M, Bono N, Pavarini M, Tarsini P, Candiani G et al. Antibacterial Titanium Dioxide Coatings for Cocrmo Orthopaedic Implants. Applied Surface Science. 2023 Jan; 609: 155300. doi: 10.1016/j.apsusc.2022.155300.
Wang Y, Ding Y, Deng J, Nie R, Meng X. Antibacterial One-Step Self-Etching Dental Adhesive with Silver Nanoparticles Synthesized in Situ. Journal of Dentistry. 2023 Feb; 129: 104411. doi: 10.1016/j.jdent.2023.104411.
Konopatsky AS, Teplyakova TO, Popova DV, Vlasova KY, Prokoshkin SD, Shtansky DV. Surface Modification and Antibacterial Properties of Superelastic Ti-Zr-Based Alloys for Medical Application. Colloids and Surfaces B: Biointerfaces. 2022 Jan; 209: 112183. doi: 10.1016/j.colsurfb.2021.112183.
Bhadila G, Baras BH, Weir MD, Wang H, Melo MA, Hack GD et al. Novel Antibacterial Calcium Phosphate Nanocomposite with Long-Term Ion Recharge and Re-Release to Inhibit Caries. Dental Materials Journal. 2020 Jul; 39(4): 678-89. doi: 10.4012/dmj.2019-203.
Ding R, Qian Y, Chen M, Yi J, Zhao Z. The Effect of N-Acetylcysteine On the Antibacterial Capability and Biocompatibility of Nano Silver–Containing Orthodontic Cement. The Angle Orthodontist. 2021 Jul; 91(4): 515-21. doi: 10.2319/073120-670.1.
Mitwalli H, Balhaddad AA, AlSahafi R, Oates TW, Melo MA, Xu HH et al. Novel CaF2 Nanocomposites with Antibacterial Function and Fluoride and Calcium Ion Release to Inhibit Oral Biofilm and Protect Teeth. Journal of Functional Biomaterials. 2020 Aug; 11(3): 56. doi: 10.3390/jfb11030056.
Bahrami R, Pourhajibagher M, Badiei A, Masaeli R, Tanbakuchi B. Evaluation of the Cell Viability and Antimicrobial Effects of Orthodontic Bands Coated with Silver or Zinc Oxide Nanoparticles: An in Vitro Study. Korean Journal of Orthodontics. 2023 Jan; 53(1): 16-25. doi: 10.4041/kjod22.091.
Garcia PP, Cardia MF, Francisconi RS, Dovigo LN, Spolidório DM, de Souza Rastelli AN et al. Antibacterial Activity of Glass Ionomer Cement Modified by Zinc Oxide Nanoparticles. Microscopy Research and Technique. 2017 May; 80(5): 456-61. doi: 10.1002/jemt.22814.
Malineni MK, Chandrasekhar G, Ponnada S, Anand H, Gandikota A. Evaluation of Antibacterial Properties of Metal Brackets Coated with Graphene Oxide Nanoparticles and Its Synergistic Effect with Other Metal Oxides–An In-Vitro Study. Orthodontic Journal of Nepal. 2023 Dec; 13(2): 3-14. doi: 10.3126/ojn.v13i2.52873.
Nikolaidis AK, Koulaouzidou EA, Gogos C, Achilias DS. Synthesis of Novel Dental Nanocomposite Resins by Incorporating Polymerizable, Quaternary Ammonium Silane-Modified Silica Nanoparticles. Polymers. 2021 May; 13(11): 1682. doi: 10.3390/polym13111682.
Khan AS, Alhamdan Y, Alibrahim H, Almulhim KS, Nawaz M, Ahmed SZ et al. Analyses of Experimental Dental Adhesives Based on Zirconia/Silver Phosphate Nanoparticles. Polymers. 2023 Jun; 15(12): 2614. doi: 10.3390/polym15122614.
Al-Qarni F, Weir M, Melo MA, Al-Dulaijan Y, Almulhim KS, Xu HH. Novel Calcium Phosphate Ion-Rechargeable and Antibacterial Adhesive to Inhibit Dental Caries. Clinical Oral Investigations. 2022 Jan; 26(1): 313-23. doi: 10.1007/s00784-021-04002-7.
Zeidan NK, Enany NM, Mohamed GG, Marzouk ES. The Antibacterial Effect of Silver, Zinc-Oxide and Combination of Silver/Zinc Oxide Nanoparticles Coating of Orthodontic Brackets (An in Vitro study). BioMed Central Oral Health. 2022 Jun; 22(1): 230. doi: 10.1186/s12903-022-02263-6.
Al Tuma RR and Yassir YA. Effect of Calcium Fluoride Nanoparticles in Prevention of Demineralization During Orthodontic Fixed Appliance Treatment: A Randomized Clinical Trial. European Journal of Orthodontics. 2023 Apr; 45(2): 122-32. doi: 10.1093/ejo/cjac055.
Sen D, Patil V, Smriti K, Varchas P, Ratnakar R, Naik N et al. Nanotechnology and Nanomaterials in Dentistry: Present and Future Perspectives in Clinical Applications. Engineered Science. 2022 Apr; 20: 14-24. doi: 10.30919/es8d703.
Makvandi P, Josic U, Delfi M, Pinelli F, Jahed V, Kaya E et al. Drug Delivery (Nano) Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management. Advanced Science. 2021 Apr; 8(8): 2004014. doi: 10.1002/advs.202004014.
Yin IX, Zhang J, Zhao IS, Mei ML, Li Q, Chu CH. The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry. International Journal of Nano-medicine. 2020 Apr; 15: 2555-62. doi: 10.2147/IJN.S246764.
Moghadam ET, Yazdanian M, Tahmasebi E, Tebyanian H, Ranjbar R, Yazdanian A et al. Current Herbal Medicine as an Alternative Treatment In Dentistry: In Vitro, In Vivo and Clinical Studies. European Journal of Pharmacology. 2020 Dec; 889: 173665. doi: 10.1016/j.ejphar.2020.173665.
Rajasekar N, Mohanraj KG, Martin TM. Advanced Dental Care: β-Chitosan Zinc Oxide Nanoparticles Targeting Cariogenic Microorganisms. Cureus. 2024 Aug; 16(8): e66296. doi: 10.7759/cureus.66296.
Mondal S, Park S, Choi J, Vu TT, Doan VH, Vo TT et al. Hydroxyapatite: A Journey from Biomaterials to Advanced Functional Materials. Advances in Colloid and Interface Science. 2023 Oct; 321: 103013. doi: 10.1016/j.cis.2023.103013.
El-Deeb M, Ismail MM, Kenawy ER, Habib NA. Evaluation of Antibacterial Activity of an Experimental Dental Adhesive Containing Synthesized Quaternary Ammonium Compound: In Vitro Study. Discover Applied Sciences. 2024 Mar; 6(3): 120. doi: 10.1007/s42452-024-05756-x.
Pavanello L, Cortês IT, de Carvalho RD, Dal Picolo MZ, Cavalli V, Silva LT et al. Physicochemical and Biological Properties of Dental Materials and Formulations with Silica Nanoparticles: A Narrative Review. Dental Materials. 2024 Aug; 40(11): 1729-1741. doi: 10.1016/j.dental.2024.07.028.
Zyoud SH, Ganesh V, Che Abdullah CA, Yahia IS, Zyoud AH, Abdelkader AF et al. Facile Synthesis of Ni-Doped ZnO Nanostructures Via Laser-Assisted Chemical Bath Synthesis with High and Durable Photocatalytic Activity. Crystals. 2023 Jul; 13(7): 1087. doi: 10.3390/cryst13071087.
Xu J and Chow EK. Biomedical Applications of Nano-diamonds: From Drug-Delivery to Diagnostics. SLAS Technology. 2023 Aug; 28(4): 214-22. doi: 10.1016/j.slast.2023.03.007.
Al Qtaish N, Gallego I, Paredes AJ, Villate-Beitia I, Soto-Sánchez C, Martínez-Navarrete G et al. Nano-Diamond Integration into Niosomes as an Emerging and Efficient Gene Therapy Nano-Platform for Central Nervous System Diseases. American Chemical Society Applied Materials and Interfaces. 2022 Mar; 14(11): 13665-77. doi: 10.1021/acsami.2c02182.
Montoya C, Roldan L, Yu M, Valliani S, Ta C, Yang M et al. Smart Dental Materials for Antimicrobial Applications. Bioactive Materials. 2023 Jun; 24: 1-9. doi: 10.1016/j.bioactmat.2022.12.002.
Azmi AH, Adnan SN, Ab Malik N. The Prevalence of Staphylococcus Aureus in the Oral Cavity of Healthy Adults in Malaysia. Sains Malaysia. 2020 Mar; 49(3): 583-91. doi: 10.17576/jsm-2020-4903-13.
Ahmad N, Jafri Z, Khan ZH. Evaluation of Nanomaterials to Prevent Oral Candidiasis in PMMA Based Denture Wearing Patients. A Systematic Analysis. Journal of Oral Biology and Craniofacial Research. 2020 Apr; 10(2): 189-93. doi: 10.1016/j.jobcr.2020.04.012.
Benkova M, Soukup O, Marek J. Antimicrobial Susceptibility Testing: Currently Used Methods and Devices and the Near Future in Clinical Practice. Journal of Applied Microbiology. 2020 Oct; 129(4): 806-22. doi: 10.1111/jam.14704.
Camilleri J, Moliz TA, Bettencourt A, Costa J, Martins F, Rabadijeva D et al. Standardization of Antimicrobial Testing of Dental Devices. Dental Materials. 2020 Mar; 36(3): e59-73. doi: 10.1016/j.dental.2019.12.006.
Subramani K, Seo HN, Dougherty J, Chaudhry K, Bollu P, Rosenthal KS et al. In Vitro Evaluation of Antimicrobial Activity of Chlorhexidine Hexametaphosphate Nanoparticle Coatings on Orthodontic Elastomeric Chains. Materials Research Express. 2020 Jul; 7(7): 075401. doi: 10.1088/2053-1591/ab9e8b.
Gligorijević N, Mihajlov-Krstev T, Kostić M, Nikolić L, Stanković N, Nikolić V et al. Antimicrobial Properties of Silver-Modified Denture Base Resins. Nanomaterials. 2022 Jul; 12(14): 2453. doi: 10.3390/nano12142453.
Sihivahanan D and Nandini VV. Comparative Evaluation of Mechanical Properties of Titanium Dioxide Nanoparticle Incorporated in Composite Resin as A Core Restorative Material. The Journal of Contemporary Dental Practice. 2021 Aug; 22(6): 686-90. doi: 10.5005/jp-journals-10024-3105.
Jowkar Z, Fattah Z, Ghanbarian S, Shafiei F. The Effects of Silver, Zinc Oxide, and Titanium Dioxide Nanoparticles Used as Dentin Pre-treatments On the Micro-shear Bond Strength of a Conventional Glass Ionomer Cement to Dentin. International Journal of Nano-medicine. 2020 Jul; 15: 4755-62. doi: 10.2147/IJN.S262664.
Bruna T, Maldonado-Bravo F, Jara P, Caro N. Silver Nanoparticles and Their Antibacterial Applications. International Journal of Molecular Sciences. 2021 Jul; 22(13): 7202. doi: 10.3390/ijms22137202.
Cronin MC, Awasthi MA, Conway MA, O’Riordan D, Walsh J. Design and Development of a Material Handling System for an Autonomous Intelligent Vehicle for Flexible Manufacturing. Procedia Manufacturing. 2020 Jan; 51: 493-500. doi: 10.1016/j.promfg.2020.10.069.
Yudaev P, Chuev V, Klyukin B, Kuskov A, Mezhuev Y, Chistyakov E. Polymeric Dental Nanomaterials: Antimicrobial Action. Polymers. 2022 Feb; 14(5): 864. doi: 10.3390/polym14050864.
Nanjundeswaraswamy TS and Divakar S. Determination of Sample Size and Sampling Methods in Applied Research. Proceedings On Engineering Sciences. 2021 Mar; 3(1): 25-32. doi: 10.24874/PES03.01.003.
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