Biochemical Effects of Oral Contraceptive Pills on Serum Bilirubin, Creatinine and Antioxidants System Among Females: Oral Contraceptive Pills on Serum Bilirubin, Creatinine and Antioxidants System

Muhammad  Jamil; Muhammad Zafar  Iqbal Butt; Shahzaman  Khan; Aftab Ahmad Jan; Sumaiya  Amanat Ali; Alamgir  Khan; Zeliha  Selamoglu; Javed  Ali Soomro; Ata Ur  Rehman

doi:10.54393/pjhs.v3i05.198

Authors

Muhammad Jamil Center of Physical Education, Health & Sports Sciences, University of Sindh, Jamshoro, Sindh
Muhammad Zafar Iqbal Butt Department of Sports Sciences and Physical Education, University of the Punjab, Lahore, Pakistan
Shahzaman Khan Department of Physical Education and Sports Sciences, Sukkur Institute of Business Administration, Sukkur, Pakistan
Aftab Ahmad Jan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, KPK, Pakistan
Sumaiya Amanat Ali Faculty of Health and Medicine USYD, Sydney, Australia
Alamgir Khan Department of Sports Sciences and Physical Education, University of the Punjab, Lahore, Pakistan
Zeliha Selamoglu Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde, Turkey
Javed Ali Soomro Department of Physical Education, Health & Sports Sciences, University of Sindh, Jamshoro, Sindh
Ata Ur Rehman Institute of Biological Sciences, Gomal University, Dera Ismail Khan, KPK, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v3i05.198

Keywords:

Serum bilirubin, Serum Creatinine, Oxidative Stress, Oral Contraceptive Pills

Abstract

Both estrogens and progestogens antifertility agents are used by huge number of females. Excessive use of antifertility agents caused toxic effects on body systems. Liver play its key role in the metabolic process of these toxic antifertility agents. Objective: To examine the biochemical effects of oral contraceptive pills on serum bilirubin, creatinine and antioxidants system among females. Methods: Participants of the study were categorized in to two groups i.e. control group (CG) (female using no contraceptive pills) and experimental group (EG) (females using contraceptive pills). Five (05) ml of blood was collected from each subject by vein cut and an expendable syringe. All blood samples were marked with separate identification code or mark. Ferric reducing assay protocol (FRAP) was applied for measuring oxidative stress and liver functions test (LFTs) was performed for measuring serum bilirubin and creatinine. Results: The collected data were tabulated and were analyzed by using mean, standard deviation, frequency and percentage etc. through the application of statistical package for social sciences (SPSS, version-26.0). Conclusions: Based on analysis the researcher draws the conclusion that oral contraceptive pills (OCP) have significant effect on serum bilirubin (p-value was 0.004), serum creatinine (p-value 0.023) and oxidative stress (p-value 0.002).

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