Biochemical Effects of Oral Contraceptive Pills on Serum Bilirubin, Creatinine and Antioxidants System Among Females

Oral Contraceptive Pills on Serum Bilirubin, Creatinine and Antioxidants System


  • Muhammad Jamil Center of Physical Education, Health & Sports Sciences, University of Sindh, Jamshoro, Sindh
  • Muhammad Zafar Iqbal Butt Department of Sports Sciences and Physical Education, University of the Punjab, Lahore, Pakistan
  • Shahzaman Khan Department of Physical Education and Sports Sciences, Sukkur Institute of Business Administration, Sukkur, Pakistan
  • Aftab Ahmad Jan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, KPK, Pakistan
  • Sumaiya Amanat Ali Faculty of Health and Medicine USYD, Sydney, Australia
  • Alamgir Khan Department of Sports Sciences and Physical Education, University of the Punjab, Lahore, Pakistan
  • Zeliha Selamoglu Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde, Turkey
  • Javed Ali Soomro Department of Physical Education, Health & Sports Sciences, University of Sindh, Jamshoro, Sindh
  • Ata Ur Rehman Institute of Biological Sciences, Gomal University, Dera Ismail Khan, KPK, Pakistan



Serum bilirubin, Serum Creatinine, Oxidative Stress, Oral Contraceptive Pills


Both estrogens and progestogens antifertility agents are used by huge number of females. Excessive use of antifertility agents caused toxic effects on body systems. Liver play its key role in the metabolic process of these toxic antifertility agents. Objective: To examine the biochemical effects of oral contraceptive pills on serum bilirubin, creatinine and antioxidants system among females. Methods: Participants of the study were categorized in to two groups i.e. control group (CG) (female using no contraceptive pills) and experimental group (EG) (females using contraceptive pills). Five (05) ml of blood was collected from each subject by vein cut and an expendable syringe. All blood samples were marked with separate identification code or mark. Ferric reducing assay protocol (FRAP) was applied for measuring oxidative stress and liver functions test (LFTs) was performed for measuring serum bilirubin and creatinine. Results: The collected data were tabulated and were analyzed by using mean, standard deviation, frequency and percentage etc. through the application of statistical package for social sciences (SPSS, version-26.0). Conclusions: Based on analysis the researcher draws the conclusion that oral contraceptive pills (OCP) have significant effect on serum bilirubin (p-value was 0.004), serum creatinine (p-value 0.023) and oxidative stress (p-value 0.002).


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DOI: 10.54393/pjhs.v3i05.198
Published: 2022-10-31

How to Cite

Jamil, M. ., Iqbal Butt, M. Z. ., Khan, S. ., Ahmad Jan, A., Amanat Ali, S. ., Khan, A. ., Selamoglu, Z. ., Ali Soomro, J. ., & Rehman, A. U. . (2022). Biochemical Effects of Oral Contraceptive Pills on Serum Bilirubin, Creatinine and Antioxidants System Among Females: Oral Contraceptive Pills on Serum Bilirubin, Creatinine and Antioxidants System. Pakistan Journal of Health Sciences, 3(05), 46–49.



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