Effects of Combined Glucosamine/Chondroitin With Structured Physical Therapy Program On Knee Osteoarthritis: A Randomized Control Trail

Effects of Combined Glucosamine/Chondroitin on Knee Osteoarthritis

Authors

  • Muhammad Salman Department of Neurology, Center of Advanced Studies in Health & Technology, Rawalpindi, Pakistan
  • Aamer Naeem Department of Rehabilitation Sciences, Foundation University Islamabad, Pakistan
  • Muhammad Umar Department of Rehabilitation Sciences, IAHS, Rawalpindi Medical University, Rawalpindi, Pakistan
  • Somiya Asif Department of Physiotherapy, Margalla Institute of Health Sciences, Islamabad, Pakistan
  • Kiran Haq Department of Physiotherapy, Rawal Institute of Health Sciences, Islamabad, Pakistan
  • Muhammad Saad Hasan Department of Physiotherapy, Rawal Institute of Rehabilitation Sciences Islamabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v3i07.410

Keywords:

Osteoarthritis, Glucosamine Chondroitin, Physiotherapy, WOMAC scale, SF-36

Abstract

Osteoarthritis is the most debilitating condition in general population. The incidence rate of this condition is very high. Objective: this study was conducted to observe the effectiveness of glucosamine/chondroitin alone and in combination with physiotherapy on Knee osteoarthritis. Methods: A randomized control trail registered at clinicaltrials.gov under the trail no of NCT05321836. Data was collected from the Physiotherapy clinic and Neurocounsel Hospital Islamabad from 26 July 2021 to 25th March 2022. 30 participants met inclusion criteria and were randomly divided into two groups via envelop method. The experimental group was given unlabeled 1500/1200 mg of GH/CS per day for period of 6 months along with physiotherapy treatment for two months (3 sessions per week). The Control group was treated with 1500/1200 mg of unlabeled GH/CS per day for 6 months. Tools used to measure the outcome were WOMAC scale & SF-36. Measure were taken at baseline, 4th week and at 8th week. Repeated Measure ANOVA was used to analyze results at various weeks and Post Hoc analysis was opted for comparison between groups. SPSS version 21.0 was used for data analysis 

Results: Means+S.D of age in experimental & control group was 64.80+9.65, 60.93+7.61respectively. Repeated measure ANOVA within both groups significant difference at various weeks of treatment as p<0.05. Between groups, Independent t’ test also revealed statistically significant difference as p-value was <0.05. Conclusion: GH/CS along with physiotherapy is very effective in reducing patient’s pain, improving functions, mobility along with quality of life as compared to GH/CS alone.

 

References

Yue L, Berman J. What Is Osteoarthritis?. JAMA. 2022 Apr; 327(13): 1300. doi: 10.1001/jama.2022.1980.

Dório M and Deveza LA. Phenotypes in Osteoarthritis: Why Do We Need Them and Where Are We At?. Clinics in Geriatric Medicine. 2022 May; 38(2): 273-86. doi: 10.1016/j.cger.2021.11.002.

Kaplunov OA and Kaplunov KO. Clinical cases of using SYSADOA in complex conservative therapy of a patient with osteoarthritis of the knee joint. Attending doctor. 2021 Sep; 3(7): 49-52. doi: 10.51793/OS.2021.24.7.009

Telyshev K, Alekseeva L, Lila A, Baranov A, Trofimov E. AB0885 Effectiveness and safety of glucosamine and chondroitin combination in patients with knee and hip osteoarthritis: interim analysis results of an observational study. Annals of the Rheumatic Diseases 2020; 79: 1747. doi: 10.1136/annrheumdis-2020-eular.3079.

Ogata T, Ideno Y, Akai M, Seichi A, Hagino H, Iwaya T, Yamada K, et al. Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis. Clinical Rheumatology. 2018 Sep; 37(9): 2479-87. doi: 10.1007/s10067-018-4106-2

Knoll N, Hohl DH, Motter S, Keller J, Lange D, Felsenberg D, et al. Facilitating physical activity and reducing symptoms in patients with knee osteoarthritis: study protocol of a randomized controlled trial to test a theory-based PrevOP-psychological adherence program (PrevOP-PAP). BMC Musculoskeletal Disorders. 2018 Dec; 19(1): 1-6. doi: 10.1186/s12891-018-2158-8

Fernández-Martín, S., González-Cantalapiedra, A., Muñoz, F., García-González, M., Permuy, M. and López-Peña, M., 2021. Glucosamine and Chondroitin Sulfate: Is There Any Scientific Evidence for Their Effectiveness as Disease-Modifying Drugs in Knee Osteoarthritis Preclinical Studies?—A Systematic Review from 2000 to 2021 May. Animals; 11(6): 1608-37. doi: 10.3390/ani11061608

de Vos, B.C., Landsmeer, M.L., van Middelkoop, M., Oei, E.H., Krul, M., Bierma-Zeinstra, S.M. and Runhaar, J., 2017. Long-term effects of a lifestyle intervention and oral glucosamine sulphate in primary care on incident knee OA in overweight women. Rheumatology. 2017 Aug; 56(8): 1326-1334. doi: 10.1093/rheumatology/kex145

Armagan O, Yilmazer S, Calısir C, Ozgen M, Tascioglu FU, Oner S, Akcar N. Comparison of the symptomatic and chondroprotective effects of glucosamine sulphate and exercise treatments in patients with knee osteoarthritis. Journal of Back and Musculoskeletal Rehabilitation. 2015 Jan; 28(2): 287-93. doi: 10.3233/BMR-140516

Blanco FJ, Camacho-Encina M, González-Rodríguez L, Rego-Pérez I, Mateos J, Fernández-Puente P, et al. Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis. Therapeutic advances in chronic disease. 2019 Aug; 10: 1-12. doi: 10.1177/2040622319870013

Hochberg MC, Martel-Pelletier J, Monfort J, Möller I, Castillo JR, Arden N, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Annals of the rheumatic diseases. 2016 Jan; 75(1): 37-44. doi: 10.1136/annrheumdis-2014-206792

Conrozier T, Lohse T. Glucosamine as a Treatment for Osteoarthritis: What If It’s True?. Frontiers in Pharmacology. 2022 Mar; 13: 652. doi: 10.3389/fphar.2022.820971

Newberry SJ, FitzGerald J, SooHoo NF, Booth M, Marks J, Motala A, et al. Treatment of osteoarthritis of the knee: an update review. Agency for Healthcare Research and Quality. 2017

Babur MN, Siddiqi FA, Tassadaq N, Tareen MA, Osama M. Effects of glucosamine and chondroitin sulfate supplementation in addition to resistance exercise training and manual therapy in patients with knee osteoarthritis: A randomized controlled trial. Journal of Pakistan Medical Association. 2020 Jul; 72(7): 1272-77

Bricca A, Juhl CB, Steultjens M, Wirth W, Roos EM. Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: a systematic review of randomised controlled trials. British journal of sports medicine. 2019 Aug; 53(15): 940-7. doi: 10.1136/bjsports-2017-098661

Aras D, Islam AA, Arif SK, Arief M. Effects of Combined Physiotherapy Hold Relax and Glucosamine to the Decrease of COMP through Pain reduction, Increase Muscle Strength and addition of Osteoarthritis of the Knee Joint ROM. International Journal of Sciences: Basic and Applied Research. 2015; 4531: 348-63.

Juhl C, Christensen R, Roos EM, Zhang W, Lund H. Impact of exercise type and dose on pain and disability in knee osteoarthritis: a systematic review and meta‐regression analysis of randomized controlled trials. Arthritis & rheumatology. 2014 Mar; 66(3): 622-36. doi: 10.1002/art.38290

Skou ST, Roos EM, Laursen MB, Rathleff MS, Arendt-Nielsen L, Rasmussen S, et al. Total knee replacement and non-surgical treatment of knee osteoarthritis: 2-year outcome from two parallel randomized controlled trials. Osteoarthritis and cartilage. 2018 Sep; 26(9): 1170-80. doi: 10.1016/j.joca.2018.04.014

Pedersen BK, Saltin B. Exercise as medicine–evidence for prescribing exercise as therapy in 26 different chronic diseases. Scandinavian journal of medicine & science in sports. 2015 Dec; 25: 1-72. doi: 10.1111/sms.12581

Song R, Lee EO, Lam P, Bae SC. Effects of tai chi exercise on pain, balance, muscle strength, and perceived difficulties in physical functioning in older women with osteoarthritis: a randomized clinical trial. The Journal of Rheumatology. 2003 Sep; 30(9): 2039-44.

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Published

2022-12-31
CITATION
DOI: 10.54393/pjhs.v3i07.410
Published: 2022-12-31

How to Cite

Salman, M. ., Naeem, A. ., Umar, M. ., Asif, S. ., Haq, K. ., & Saad Hasan, M. . (2022). Effects of Combined Glucosamine/Chondroitin With Structured Physical Therapy Program On Knee Osteoarthritis: A Randomized Control Trail : Effects of Combined Glucosamine/Chondroitin on Knee Osteoarthritis. Pakistan Journal of Health Sciences, 3(07), 83–87. https://doi.org/10.54393/pjhs.v3i07.410

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