Evaluation of Mean Platelet Volume in Patients of Recurrent Aphthous Stomatitis

Mean Platelet Volume in Patients of RAS


  • Mujtaba Nadeem Department of Oral and Maxillofacial Surgery, Avicenna Dental College, Lahore, Pakistan
  • Usman Manzoor Department of Oral and Maxillofacial Surgery, Avicenna Dental College, Lahore, Pakistan
  • Uzma Tariq Department of Oral Pathology, Isra Dental College, Isra University, Hyderabad, Pakistan
  • Sufyan Ahmed Department of Oral and Maxillofacial Surgery, Karachi Medical and Dental College, Karachi, Pakistan
  • Awais Akbar Department of Oral and Maxillofacial Surgery, Fatima Jinnah Dental College, Karachi, Pakistan
  • Syed Aijaz Ali Zaidi Department of Oral Medicine, Baqai Dental College, Baqai Medical University, Karachi Pakistan




Recurrent Aphthous Stomatitis, Mean Platelet Volume, Evaluation


One of the most prevalent conditions affecting the oral mucosa is recurrent aphthous stomatitis (RAS), which is characterized by uncomfortable ulcerations on the movable or non-keratinized oral mucosa. Objective: To compare mean platelet volume (MPV) in patients of recurrent aphthous stomatitis (RAS) versus healthy control. Methods: This non-probability sampling case-control research included 56 RAS patients and 56 healthy controls. Patients who presented for dental treatment and have RAS in oral cavity were included.  Patients with systemic inflammatory illnesses, autoimmune diseases like pemphigus, or infectious diseases like herpes who attended for dental treatment and exhibited RAS in the oral cavity were excluded. The healthy control group had no mouth ulcers or blood problems. A Student t-test compared MPV between cases and controls based on age, gender, and MPV. Results: The mean age of the participants was 29.35 ± 8.28 years, with 57 (50.89%) females and 55 (49.11%) males. The mean MPV in the RAS group (8.86 ± 0.33) was significantly higher (p < 0.001) than in the control group (6.95 ± 0.2). The univariable model coefficient of 1.91 (95% CI = 1.81-2.01, p < 0.001) indicates that the RAS group had a significantly higher MPV than the Control group. For gender, males had a lower MPV compared to females (β = -0.36), but it was not statistically significant (p = 0.056). Conclusions: RAS patients have higher platelet activity indicated by higher mean platelet volume (MPV) than healthy controls.


Ślebioda Z, Szponar E, Kowalska A. Recurrent aphthous stomatitis: genetic aspects of etiology. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2013 Apr; 30(2): 96-102. doi: 10.5114/pdia.2013.34158.

Safi S, Manzoor S, Nasir U, Ullah F, Durrani N, Taj F. Aphthous Ulceration–Risk Factors Among Dental Students at Khyber College of Dentistry, Peshawar. Journal of Gandhara Medical and Dental Science. 2021 Jul; 8(3): 47-52. doi: 10.37762/jgmds.8-3.195.

Akintoye SO and Greenberg MS. Recurrent aphthous stomatitis. Dental Clinics. 2014 Apr; 58(2): 281-97. doi: 10.1016/j.cden.2013.12.002.

Cui RZ, Bruce AJ, Rogers III RS. Recurrent aphthous stomatitis. Clinics in Dermatology. 2016 Jul; 34(4): 475-81. 10.1016/j.clindermatol.2016.02.020.

Femiano F, Lanza A, Buonaiuto C, Gombos F, Nunziata M, Piccolo S, et al. Guidelines for diagnosis and management of aphthous stomatitis. The Pediatric Infectious Disease Journal. 2007 Aug; 26(8): 728-32. doi: 10.1097/INF.0b013e31806215f9.

Montgomery-Cranny JA, Wallace A, Rogers HJ, Hughes SC, Hegarty AM, Zaitoun H. Management of recurrent aphthous stomatitis in children. Dental Update. 2015 Jul; 42(6): 564-72. doi: 10.12968/denu.2015.42.6.564.

Şenel E, Acar B, Demir E. Mean platelet volume: A reliable marker of inflammation in recurrent apthous stomatitis and behcet disease?. Indian Dermatology Online Journal. 2017 Nov; 8(6): 468. doi: 10.4103/idoj.IDOJ_405_16.

Sánchez J CC and Conejero R. Recurrent aphthous stomatitis. Actas DermoSifiliográf. 2020 Jul; 111(6): 471-80. doi: 10.1016/j.adengl.2019.09.006.

Terzi S, Dursun E, Özgür A, Yiğit E, Özergin-Coşkun Z, Çelebi-Erdivanl Ö, et al. Status of neutrophils, lymphocytes and platelets in patients with recurrent aphthous stomatitis: a retrospective study. Iranian Journal of Otorhinolaryngology. 2016 Nov; 28(89): 421.

Enache D, Pariante CM, Mondelli V. Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue. Brain, Behavior, and Immunity. 2019 Oct; 81: 24-40. doi: 10.1016/j.bbi.2019.06.015.

Neville BW DD, Allen CM, Chi AC. Oral and Maxillofacial Pathology. 4th ed. Philadelphia: Elsevier; 2016: 303e10.

Simsek G, Haytoglu S, Muluk NB, Arikan OK, Cortuk M, Kiraz K. Mean platelet volume decreases in adult patients with obstructive sleep apnea after uvulopalatal flap surgery. Journal of Craniofacial Surgery. 2015 Oct; 26(7): 2152-4. doi: 10.1097/SCS.0000000000001954.

Günbey E, Karabulut I, Karabulut H, Zaim M. Impact of multilevel surgical treatment on mean platelet volume in patients with obstructive sleep apnea syndrome. Journal of Craniofacial Surgery. 2015 Jun; 26(4): 1287-9. doi: 10.1097/SCS.0000000000001556.

Şereflican M ŞB, Tuman B, Göksügür N, Kesgin S, Yurttaş V. Evaluation of mean platelet volume and neutrophil to lymphocyte ratio as a diagnostic indicator in patients with recurrent aphthous stomatitis. ENT Updates. 2016 Aug; 6(2): 82-6. doi: 10.2399/jmu.2016002008.

Biyik Ozkaya D, KÜÇÜK Ö, Onsun N. Comparing Mean Platelet Volume Values in Patients with Recurrent Aphthous Stomatitis and Patients with Behcet's Disease. Bezmialem Science. 2018 Aug; 6(3): 252-6. doi: 10.14235/bs.2018.1587.

Karaer IC. Mean platelet volume, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio as inflammatory markers in patients with recurrent aphthous stomatitis. The Eurasian Journal of Medicine. 2020 Feb; 52(1): 38. doi: 10.5152/eurasianjmed.2019.18486.

Preeti L MK, Rajkumar K, Karthik R. Recurrent aphthous stomatitis. Journal of Oral Maxillofacial Pathology. 2011 Sep; 15(3): 252-6. doi: 10.4103/0973-029X.86669.

Ekiz O, Balta I, Sen BB, Rifaioglu EN, Ergin C, Balta S, et al. Mean platelet volume in recurrent aphthous stomatitis and Behçet disease. Angiology. 2014 Feb; 65(2): 161-5. doi: 10.1177/0003319713492375.

Uluyol S and Kilicaslan S. Diagnostic Value of Neutrophil–Lymphocyte Ratios and Mean Platelet Volumes in the Activation of Recurrent Aphthous Stomatitis. Indian Journal of Otolaryngology and Head & Neck Surgery. 2019 Mar; 71: 120-3. doi: 10.1007/s12070-017-1059-8.

Maheswaran T, Yamunadevi A, Ilayaraja V, Dineshshankar J, Yoithapprabhunath TR, Ganapathy N. Correlation between the menstrual cycle and the onset of recurrent aphthous stomatitis. Journal of Indian Academy Dental Specialist Researchers. 2015 Jan; 2(1): 25. doi: 10.4103/2229-3019.166117.

Turan Ç, Metin N, Utlu Z, Tezcan D. Mean platelet volume as a predictor in the differentiation of Behçet's disease from recurrent aphthous stomatitis–A single centre, prospective, case‐control study. International Journal of Clinical Practice. 2021 Nov; 75(11): e14866. doi: 10.1111/ijcp.14866.

Darjani A, Joukar F, Naghipour M, Asgharnezhad M, Mansour-Ghanaei F. Lifetime prevalence of recurrent aphthous stomatitis and its related factors in Northern Iranian population: The PERSIAN Guilan Cohort Study. Clinical Oral Investigations. 2021 Feb; 25: 711-8. doi: 10.1007/s00784-020-03611-y.



DOI: 10.54393/pjhs.v4i04.693
Published: 2023-04-30

How to Cite

Nadeem, M., Manzoor, U. ., Tariq, U. ., Ahmed, S. ., Akbar, A. ., & Aijaz Ali Zaidi, S. . (2023). Evaluation of Mean Platelet Volume in Patients of Recurrent Aphthous Stomatitis: Mean Platelet Volume in Patients of RAS. Pakistan Journal of Health Sciences, 4(04), 57–61. https://doi.org/10.54393/pjhs.v4i04.693



Original Article