Frequency Of Uterine Anomalies Associated with Persistent Miscarriages in Pregnancy on Ultrasound

Uterine Anomalies Associated with Persistent Miscarriages

Authors

  • Sahil Pervaiz University Institute of Radiological Sciences and Medical Imaging, The University of Lahore, Gujrat Campus
  • Muhammad Ahmad Naeem University Institute of Radiological Sciences and Medical Imaging, The University of Lahore, Gujrat Campus
  • Abid Ali Department of Allied Health Sciences, The University of Chenab, Gujrat
  • Akash John University Institute of Radiological Sciences and Medical Imaging, The University of Lahore, Gujrat Campus
  • Narjis Batool University Institute of Radiological Sciences and Medical Imaging, The University of Lahore, Gujrat Campus

DOI:

https://doi.org/10.54393/pjhs.v3i01.54

Keywords:

Miscarriages, Uterine fibroids, Cervical incompetence, Uterine adhesions, Mullerian duct anomalies

Abstract

Miscarriages is when an embryo/foetus expires before the tenth week of gestation. It occurs most commonly early during pregnancy. Women who had a miscarriage looked to be more likely to die before the age of 70 than those who had any other pregnancy outcomes. Objective: To determine the frequency of uterine abnormalities related with persistent miscarriages in pregnancy on ultrasound. Methods: It was a cross-sectional study conducted over a period of 4 months from February 2022 to May 2022. A sample size of 70 patients was collected using purposive sampling technique. Data was collected from Memorial Christian Hospital Sialkot. Patients with multiple miscarriages due to uterine abnormalities were included in the current study. Patients with less than two miscarriages, self-induced miscarriages and miscarriages due to foetal anomalies were excluded. Data was analysed using SPSS version 20.0. Results: The study showed that the mean age of affected women experiencing miscarriage is 28.72. The highest rate of miscarriage was found in 38 (54.3%) of females and least in 4 (5.7%). The common cause of miscarriage was fibroids. Out of 70 females, 34 (48.6%) had fibroids, 14 (20%) had cervical incompetence, 9 (12.9%) had uterine adhesions, 6 (8.6%) had abnormal uterine size, 4 (5.7%) had uterine polyp and remaining 3 (4.3%) had congenital anomalies. Conclusion: The study concluded that miscarriages and uterine factors are closely linked. Uterine fibroids have shown the highest percentage of patients that had undergone miscarriage.

References

Kanmaz AG, İnan AH, Beyan E, Budak A. The effects of threatened abortions on pregnancy outcomes. Ginekologia Polska. 2019 ;90(4):195-200. doi: 10.5603/GP.a2019.0035.

Dugas C, Slane VH. Miscarriage. InStatPearls [Internet] 2021 Jun. StatPearls Publishing.

Marquardt U. Management of miscarriage and ectopic pregnancy. Emergency Nurse. 2011 Nov; 19(7):29-35; quiz 37. doi: 10.7748/en2011.11.19.7.29.c8814.

Ali S, Majid S, Niamat Ali M, Taing S, El-Serehy HA, Al-Misned FA. Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients. Saudi Journal of Biological Sciences. 2020 Oct; 27(10):2809-2817. doi: 10.1016/j.sjbs.2020.06.049.

Claramonte Nieto M, Meler Barrabes E, Garcia Martínez S, Gutiérrez Prat M, Serra Zantop B. Impact of aging on obstetric outcomes: defining advanced maternal age in Barcelona. BMC Pregnancy Childbirth. 2019 Sep; 19(1):342. doi: 10.1186/s12884-019-2415-3.

Carrascosa P, Capuñay C. Normal Radiologic Anatomy of Female Reproductive System. In Clinical Atlas of CT Virtual Hysterosalpingography. Springer, Cham. 2021: 7-39. Doi: 10.1007/978-3-030-66207-3_2.

Saravelos SH, Cocksedge KA, Li TC. The pattern of pregnancy loss in women with congenital uterine anomalies and recurrent miscarriage. Reproductive Biomedicine Online. 2010 Mar; 20(3):416-22. doi: 10.1016/j.rbmo.2009.11.021.

Preisler J, Kopeika J, Ismail L, Vathanan V, Farren J, Abdallah Y, et al. Defining safe criteria to diagnose miscarriage: prospective observational multicentre study. BMJ. 2015 Sep; 351:h4579. doi: 10.1136/bmj.h4579.

Mukhopadhaya N, Asante GP, Manyonda IT. Uterine fibroids: impact on fertility and pregnancy loss. Obstetrics, Gynaecology & Reproductive Medicine. 2007 Nov; 17(11):311-7. Doi: /10.1016/j.ogrm.2007.08.005.

Gebrekidane A, Asrat K, Simel LL, Nanduri L. A Case Study of Recurrent Miscarriage Due to Uterine Anomaly atOrotta Referral Hospital Asmara–Eritrea. International Journal of Obstetrics and Gynaecology Research (IJOGR). 2018; 5 (3): 658-66.

Parmar AM, Agarwal DP, Hathila N, Singel T. Sonographic measurements of uterus and its correlation with different parameters in parous and nulliparous women. International Journal of Medical Science and Education. 2016 Jul; 3:306-10.

Kitayama R. A Case of Miscarriage Caused by a Small Uterus following Childhood Chemotherapy. Case Reports in Oncology. 2019 Jun; 12(2):443-446. doi: 10.1159/000500952.

Thirunavakkarasu K, Dutta P, Sridhar S, Dhaliwal L, Prashad GR, Gainder S, et al. Macroprolactinemia in hyperprolactinemic infertile women. Endocrine. 2013 Dec; 44(3):750-5. doi: 10.1007/s12020-013-9925-y.

Leon IG. Helping families cope with perinatal loss. The Global Library of Women’s Medicine. 2008 Apr. Doi: 10.3843/glowm.10418.

Mukhopadhaya N, Asante GP, Manyonda IT. Uterine fibroids: impact on fertility and pregnancy loss. Obstetrics, Gynaecology & Reproductive Medicine. 2007 Nov; 17(11):311-7. Doi: 10.1016/j.ogrm.2007.08.005.

Cerdeira AS, Tome M, Moore N, Lim L. Seeing red degeneration in uterine fibroids in pregnancy: proceed with caution. Lancet. 2019 Nov; 394(10212):e37. doi: 10.1016/S0140-6736(19)32322-0.

Allison JL, Schust DJ. Recurrent first trimester pregnancy loss: revised definitions and novel causes. Current Opinions on Endocrinology, Diabetes, and Obesity. 2009 Dec; 16(6):446-50. doi: 10.1097/MED.0b013e3283327fc5.

Hooker AB, de Leeuw RA, Twisk JWR, Brölmann HAM, Huirne JAF. Reproductive performance of women with and without intrauterine adhesions following recurrent dilatation and curettage for miscarriage: long-term follow-up of a randomized controlled trial. Hum Reproduction. 2021 Jan; 36(1):70-81. doi: 10.1093/humrep/deaa289.

Khaund A, Lumsden MA. Impact of fibroids on reproductive function. Best practice & research Clinical obstetrics & gynaecology. 2008 Aug; 22(4):749-60. doi: 10.1016/j.bpobgyn.2008.01.009.

Brown S. Miscarriage and its associations. Seminars in Reproductive Medicine. 2008 Sep; 26(5):391-400. doi: 10.1055/s-0028-1087105.

Kongathi SA, i Chaudhar PZ, Chauhan JU, Patel PC, Chaudhari AM. Role of Uterine Shape and Volume Abnormalities in Recurrent Pregnancy Loss (RPL). National Journal of Medical Research. 2013 Sep; 3(03):277-9.

Hirayama E, Ebina Y, Kato K, Akabane-Nakagawa K, Okuyama K. Cervical polyps in early pregnancy are a risk factor for late abortion and spontaneous preterm birth: A retrospective cohort study. International Journal of Gynecology & Obstetrics. 2022 Jan; 156(1):64-70. doi: 10.1002/ijgo.13608.

Shen M, Duan H, Chang Y, Lin Q. Prevalence and risk factors of intrauterine adhesions in women with a septate uterus: a retrospective cohort study. Reproductive Biomedicine Online. 2022 May; 44(5):881-887. doi: 10.1016/j.rbmo.2022.02.004.

Kitayama R. A Case of Miscarriage Caused by a Small Uterus following Childhood Chemotherapy. Case Reports in Oncology. 2019 Jun; 12(2):443-446. doi: 10.1159/000500952.

Hartmann KE, Velez Edwards DR, Savitz DA, Jonsson-Funk ML, Wu P, Sundermann AC, et al. Prospective Cohort Study of Uterine Fibroids and Miscarriage Risk. Am J Epidemiol. 2017 Nov; 186(10):1140-1148. doi: 10.1093/aje/kwx062.

Kongathi SA, i Chaudhar PZ, Chauhan JU, Patel PC, Chaudhari AM. Role of Uterine Shape and Volume Abnormalities in Recurrent Pregnancy Loss (RPL). National Journal of Medical Research. 2013 Sep; 3(03):277-9.

Salim R, Regan L, Woelfer B, Backos M, Jurkovic D. A comparative study of the morphology of congenital uterine anomalies in women with and without a history of recurrent first trimester miscarriage. Hum Reprod. 2003 Jan; 18(1):162-6. doi: 10.1093/humrep/deg030.

Downloads

Published

2022-06-30
CITATION
DOI: 10.54393/pjhs.v3i01.54
Published: 2022-06-30

How to Cite

Pervaiz , . S. ., Ahmad Naeem , M. ., Ali , A. ., John, A. . ., & Batool , N. . (2022). Frequency Of Uterine Anomalies Associated with Persistent Miscarriages in Pregnancy on Ultrasound: Uterine Anomalies Associated with Persistent Miscarriages. Pakistan Journal of Health Sciences, 3(01), 55–58. https://doi.org/10.54393/pjhs.v3i01.54

Issue

Section

Original Article

Plaudit