Frequency of Hyperuricemia In Patients Presenting with Acute Ischaemic Stroke

Hyperuricemia in Patients with Acute Ischaemic Stroke


  • Amjad Iqbal Department of Neurology, Lady Reading Hospital, Peshawar, Pakistan
  • Zia Ullah Department of Neurology, Lady Reading Hospital, Peshawar, Pakistan
  • Arshad Iqbal Department of Neurosurgery, Lady Reading Hospital, Peshawar, Pakistan
  • Qiam Ud Din District Headquarter Hospital Timergara, Dir Lower, Pakistan
  • Aneeqa Waheed Department of Neurology, Lady Reading Hospital, Peshawar, Pakistan
  • Saeed Ur Rahman Department of Nursing, University of Health Sciences, Lahore, Pakistan



Hyperuricemia, Patients, Acute, Ischemic Stroke, Uric Acid


Hyperuricemia refers to elevated serum uric acid concentration above the upper limit of normal. Objective: To determine hyperuricemia in patients presenting with acute ischemic stroke to the Neurology ward of Lady Reading Hospital, Peshawar. Methods: A total of 153 patients were observed to the frequency of hyperuricemia in patients presenting with acute ischemic stroke. Study design was cross sectional study which was conducted for the period of 6 months. The total Sample size was calculated by using WHO sample size calculator. It was calculated using the World Health Organization software. Results: A total of 153 patients were observed to the frequency of hyperuricemia in patients presenting with acute ischemic stroke. Mean age of study participants was 52.45±1.14 years. Distribution of hyperuricemia was 114(74.5%). Mean serum uric acid level among cases of acute ischemic stroke was 06.15 ± 01.91 mg/dl while the mean serum uric acid level among control group was 05.1 ± 01.4 mg/dl. The results were highly significant p-value < 0.0001. Conclusions: Serum uric acid levels can be used to predict stroke risk. Moreover, serum uric acid can be utilized to stratify risk following a stroke. Long-term prospective research is needed to determine the involvement of serum uric acid in ischemic stroke. A trial of serum uric acid reducing medications in stroke patients as well as those at high risk of stroke may also be worthwhile.


Fang J and Alderman MH. Serum uric acid and cardiovascular mortality: the NHANES I epidemiologic follow-up study, 1971-1992. JAMA. 2000 May; 283(18): 2404-10. doi: 10.1001/jama.283.18.2404.

Sarfo FS, Akassi J, Antwi NK, Obese V, Adamu S, Akpalu A, et al. Highly prevalent hyperuricaemia is associated with adverse clinical outcomes among Ghanaian stroke patients: An observational prospective study. Ghana Medical Journal. 2015 Sep; 49(3): 165-72. doi: 10.4314/gmj.v49i3.7.

Mapoure YN, Ayeah CM, Ba H, Hentchoya R, Luma HN. The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans. Journal of Stroke and Cerebrovascular Diseases. 2018 Mar; 27(3): 783-92. doi: 10.1016/j.jstrokecerebrovasdis.2017.10.006.

Zhao J, Chen H, Liu N, Chen J, Gu Y, Chen J, et al. Role of hyper homocysteinemia and hyperuricemia in pathogenesis of atherosclerosis. Journal of Stroke and Cerebrovascular Diseases. 2017 Dec; 26(12): 2695-9. doi: 10.1016/j.jstrokecerebrovasdis.2016.10.012.

Jensson O, Gudmundsson G, Arnason A, Blöndal H, Petursdottir I, Thorsteinsson L, et al. Hereditary cystatin C (γ‐trace) amyloid angiopathy of the CNS causing cerebral hemorrhage. Acta Neurologica Scandinavica. 1987 Aug; 76(2): 102-14. doi: 10.1111/j.1600-0404.1987.tb03553.x.

Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Annals of Internal Medicine. 1999 Jul; 131(1): 7-13. doi: 10.7326/0003-4819-131-1-199907060-00003.

Derdeyn CP, Khosla A, Videen TO, Fritsch SM, Carpenter DL, Grubb RL Jr. Severe hemodynamic impairment, and border zone--region infarction. Radiology. 2001 Jul; 220(1): 195-201. doi: 10.1148/radiology.220.1.r01jl09195.

Pollanen MS and Deck JH. Directed embolization is an alternate cause of cerebral watershed infarction. Archives of Pathology Laboratory Medicine. 1989 Oct; 113(10): 1139-41.

Waterston JA, Brown MM, Butler P, Swash M. Small deep cerebral infarcts associated with occlusive internal carotid artery disease. A hemodynamic phenomenon? Archives of Neurology. 1990 Sep; 47(9): 953-7. doi: 10.1001/archneur.1990.00530090023007.

Tripathi VD and Hussain Z. A study to find out relationship in between serum uric acid level and stroke. International Journal of Advanced Medicine. 2017 Sep; 4: 1255-9. doi: 10.18203/2349-3933.ijam20173661.

George C and Minter DA. Hyperuricemia. In: StatPearls. StatPearls Publishing. 2021 Jul.

Arboix A, García-Eroles L, Massons JB, Oliveres M, Comes E. Predictive factors of early seizures after acute cerebrovascular disease. Stroke. 1997 Aug; 28(8): 1590-4. doi: 10.1161/01.STR.28.8.1590.

Karagiannis A, Mikhailidis DP, Tziomalos K, Sileli M, Savvatianos S, Kakafika A, et al. Serum uric acid as an independent predictor of early death after acute stroke. Circulation Journal. 2007 Jul; 71(7): 1120-7. doi: 10.1253/circj.71.1120.

Yadav SK, Nepal N, Niroula D. Prevalence of hyperuricemia among people of Morang district of Nepal. Journal of Nobel Medical College. 2014 Mar; 3(1): 16-21. doi: 10.3126/jonmc.v3i1.10048.

Kasner SE and Grotta JC. Emergency identification and treatment of acute ischemic stroke. Annals of Emergency Medicine. 1997 Nov; 30(5): 642-53. doi: 10.1016/S0196-0644(97)70084-2.

Uaratanawong S, Suraamornkul S, Angkeaw S, Uaratanawong R. Prevalence of hyperuricemia in Bangkok population. Clinical Rheumatology. 2011 Jul; 30(7): 887-93. doi: 10.1007/s10067-011-1699-0.

Liu H, Zhang XM, Wang YL, Liu BC. Prevalence of hyperuricemia among Chinese adults: a national cross-sectional survey using multistage, stratified sampling. Journal of Nephrology. 2014 Dec; 27(6): 653-8. doi: 10.1007/s40620-014-0082-z.

Mullins ME, Lev MH, Schellingerhout D, Gonzalez RG, Schaefer PW. Intracranial hemorrhage complicating acute stroke: how common is hemorrhagic stroke on initial head CT scan and how often is initial clinical diagnosis of acute stroke eventually confirmed? AJNR American Journal of Neuroradiology. 2005 Oct; 26(9): 2207-12.

Foerch C, Ghandehari K, Xu G, Kaul S. Exploring gender distribution in patients with acute stroke: A multi-national approach. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences. 2013 Jan; 18(1): 10.

Smitha CS and Kumar PK. A Study on Serum Uric Acid Level in Acute Ischemic Stroke. European Journal of Molecular & Clinical Medicine. 2022 Apr; 9(3): 2931-6.

Longo-Mbenza B, Luila EL, Mbete P, Vita EK. Is hyperuricemia a risk factor of stroke and coronary heart disease among Africans? International Journal of Cardiology. 1999 Sep; 71(1): 17-22. doi: 10.1016/S0167-5273(99)00097-2.

Ahn SH, Lee SH, Kim BJ, Lim KH, Bae SJ, Kim EH, et al. Higher serum uric acid is associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in healthy postmenopausal women. Osteoporosis International. 2013 Dec; 24(12): 2961-70. doi: 10.1007/s00198-013-2377-7.

Chiquete E, Ruiz-Sandoval JL, Murillo-Bonilla LM, Arauz A, Orozco-Valera DR, Ochoa-Guzmán A, et al. Serum uric acid and outcome after acute ischemic stroke: PREMIER study. Cerebrovascular Diseases. 2013 Mar; 35(2): 168-74. doi: 10.1159/000346603.




How to Cite

Iqbal, A. ., Ullah, Z. ., Iqbal, A. ., Ud Din, Q. ., Waheed, A. ., & Rahman, S. U. (2023). Frequency of Hyperuricemia In Patients Presenting with Acute Ischaemic Stroke: Hyperuricemia in Patients with Acute Ischaemic Stroke. Pakistan Journal of Health Sciences, 4(02), 22–26.



Original Article