Age and Gender Specific Associations between Hyperuricemia and Hypertension: A Cross-Sectional Study in Karachi: Age and Gender Specific Associations between Hyperuricemia and Hypertension

Yameen Bocha; Aliya Jafri; Faiza Agha; Uzma Najam; Syed Zaryab Ahmed; Samina Mohyuddin; Noureen Latif

doi:10.54393/pjhs.v6i6.3086

Authors

Yameen Bocha Department of Medicine, Sindh Government Lyari General Hospital, Karachi, Pakistan
Aliya Jafri Department of Biochemistry, Sindh Medical College, Jinnah Sindh Medical University, Karachi, Pakistan
Faiza Agha Department of Biochemistry, Liaquat National Hospital and Medical College, Karachi, Pakistan
Uzma Najam Department of Physiology, United Medical and Dental College, Karachi, Pakistan
Syed Zaryab Ahmed Department of Biochemistry, Ziauddin University, Karachi, Pakistan
Samina Mohyuddin Department of Physiology, Karachi Institute of Medical Sciences, Karachi, Pakistan
Noureen Latif Department of Internal Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i6.3086

Keywords:

Hyperuricemia, Hypertension, Serum Uric Acid, Anthropometric Indices, Gender, Age

Abstract

Hyperuricemia is increasingly linked to hypertension and various metabolic disorders. Objectives: To investigate the relationship between hyperuricemia and various anthropometric indices among individuals newly diagnosed with hypertension, with an emphasis on identifying potential age- and gender-specific patterns. Methods: The cross-sectional study enrolled 370 newly diagnosed hypertensive adults (230 male and 140 female), aged 18 years and above, using stratified sampling. Anthropometric data, blood pressure, and serum uric acid levels were recorded. Serum uric acid (SUA) levels above 7 mg/dL in males and above 6 mg/dL in females were used to define hyperuricemia. SPSS version 22.0 was used for statistical analysis. Independent t-tests, Pearson's correlation, Chi-square tests, and ANOVA were applied to analyze the data, with a significance level of p<0.05. Results: The research found a 27.5% prevalence of hyperuricemia, significantly higher in male (33.9%) than female (17.1%) (p<0.001). Male had significantly elevated systolic BP (p=0.043), waist circumference (p<0.001), and serum uric acid levels (p<0.001). Serum uric acid showed positive correlations with systolic BP (p=0.001), diastolic BP (p=0.007), BMI (p<0.001), waist circumference (p<0.001), and age (p=0.024). Hyperuricemic individuals had significantly higher age, BP, BMI, and waist circumference (all p<0.01). Females with hyperuricemia were older (p=0.04) and more frequently in the >50 age group (p=0.036). Conclusions: It was concluded that male showed a higher prevalence of hyperuricemia, while older age was a significant factor for females. These findings suggest the importance of monitoring serum uric acid as an early marker for cardiovascular and metabolic risks, particularly in populations at risk based on gender and age.

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