Prevalence and Characteristics of Early vs. Late-Onset Preeclampsia: A Cross-Sectional Descriptive Study

Prevalence and Characteristics of Early vs. Late-Onset Preeclampsia

Authors

  • Faraz Bakht Department of Obstetrics and Gynecology, Sughra Shafi Medical Complex, Narowal, Pakistan
  • Rabeea Shahid Department of Obstetrics and Gynecology, Sughra Shafi Medical Complex, Narowal, Pakistan
  • Munawar Afzal Department of Obstetrics and Gynecology, Sughra Shafi Medical Complex, Narowal, Pakistan
  • Kainat Ashraf Department of Obstetrics and Gynecology, Sughra Shafi Medical Complex, Narowal, Pakistan
  • Aqsa Khalid Department of Obstetrics and Gynecology, Sughra Shafi Medical Complex, Narowal, Pakistan
  • Anum Hayat Department of Obstetrics and Gynecology, Sughra Shafi Medical Complex, Narowal, Pakistan
  • Sajid Hameed Department of Public Health, Green International University, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i6.2987

Keywords:

Early Onset Preeclampsia, Late Onset Preeclampsia, Gestational Diabetes Mellitus , Prevalence

Abstract

Preeclampsia is the most frequent medical complication of pregnancy and a leading contributor to maternal morbidity and mortality. However, there is a lack of data on the outcomes of pre-eclamptic women, making the current study necessary. Objectives: To determine the prevalence and compare the clinical characteristics of early-onset and late-onset preeclampsia among pregnant women. Methods: It was a descriptive cross-sectional study conducted for 6 months at the Department of Obstetrics and Gynecology, Sughra Shafi Medical Complex, Narowal. It involved 95 pregnant women. Patients were selected using non-probability and consecutive sampling. Women at ≥20 weeks of gestation and diagnosed with preeclampsia were categorized as early onset (≤34 weeks) and late onset (>34 weeks) of preeclampsia, and their outcomes were compared based on age, parity, BMI and history of GDM and pre-existing hypertension. Data were analyzed using SPSS version 25.0. Results: The mean age of the patients was 26.2 ± 5.3 years, the mean gestational age was 34.4 ± 2.4 weeks, and the mean BMI was 26.9 ± 3.5 kg/m². There were 29 (30.5%) primiparas and 66 (69.5%) multiparas. Obesity was observed in 24 (25.3%) women, while 16 (16.8%) had pre-existing hypertension, and 23 (24.2%) had GDM. Early-onset preeclampsia was found in 27 (28.4%) women, while 68 (71.6%) had late-onset preeclampsia. Conclusions: It was concluded that a considerable proportion of women had early-onset preeclampsia. Both early and late onset preeclampsia warrant routine screening in pregnant women to allow timely identification and management, which may improve feto-maternal outcomes.

References

Ananth CV, Brandt JS, Hill J, Graham HL, Grover S, Schuster M et al. Historical and recent changes in maternal mortality due to hypertensive disorders in the United States, 1979 to 2018. Hypertension. 2021 Nov; 78(5): 1414-22. doi: 10.1161/HYPERTENSIONAHA.121.17661.

Khedagi AM and Bello NA. Hypertensive disorders of pregnancy. Cardiology Clinics. 2021 Feb; 39(1): 77-90. doi: 10.1016/j.ccl.2020.09.005.

Duhig K, Vandermolen B, Shennan A. Recent advances in the diagnosis and management of pre-eclampsia. F1000Research. 2018 Feb; 7: 242. doi: 10.12688/f1000research.12249.1.

Tesfa E, Nibret E, Gizaw ST, Zenebe Y, Mekonnen Z, Assefa S et al. Prevalence and determinants of hypertensive disorders of pregnancy in Ethiopia: A systematic review and meta-analysis. PLOS One. 2020 Sep; 15(9): e0239048. doi: 10.1371/journal.pone.0239048.

Elawad T, Scott G, Bone JN, Elwell H, Lopez CE, Filippi V et al. Risk factors for pre‐eclampsia in clinical practice guidelines: comparison with the evidence. BJOG: An International Journal of Obstetrics and Gynaecology. 2024 Jan; 131(1): 46-62. doi: 10.1111/1471-0528.17320.

Chaiworapongsa T, Chaemsaithong P, Yeo L, Romero R. Pre-Eclampsia Part 1: Current Understanding of Its Pathophysiology. Nature Reviews Nephrology. 2014 Aug; 10(8): 466-80. doi: 10.1038/nrneph.2014.102.

Nirupama R, Divyashree S, Janhavi P, Muthukumar SP, Ravindra PV. Preeclampsia: Pathophysiology and management. Journal of Gynecology Obstetrics and Human Reproduction. 2021 Feb; 50(2): 101975. doi: 10.1016/j.jogoh.2020.101975.

Stanek J. Histological features of shallow placental implantation unify early-onset and late-onset preeclampsia. Pediatric and Developmental Pathology. 2019 Mar; 22(2): 112-22. doi: 10.1177/1093526618803759.

Li X, Kang F, Li X, Du X, Yang Y. Comparison of characteristics between early-onset and late-onset severe preeclampsia: A retrospective cohort study from a Tertiary Hospital in China. Reproductive Sciences. 2025 Jan; 32(1): 139-49. doi: 10.1007/s43032-024-01674-w.

Teka H, Yemane A, Abraha HE, Berhe E, Tadesse H, Gebru F et al. Clinical presentation, maternal-fetal, and neonatal outcomes of early-onset versus late onset preeclampsia-eclampsia syndrome in a teaching hospital in a low-resource setting: A retrospective cohort study. PLOS ONE. 2023 Feb; 18(2): e0281952. doi: 10.1371/journal.pone.0281952.

Tesfa E, Nibret E, Munshea A. Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis. PLOS One. 2020 Dec; 15(12): e0243538. doi: 10.1371/journal.pone.0243538.

Radoń-Pokracka M, Adrianowicz B, Płonka M, Danił P, Nowak M, Huras H. Evaluation of pregnancy outcomes at advanced maternal age. Open Access Macedonian Journal of Medical Sciences. 2019 Jun; 7(12): 1951. doi: 10.3889/oamjms.2019.587.

Siddiqui A, Deneux-Tharaux C, Luton D, Schmitz T, Mandelbrot L, Estellat C et al. Maternal obesity and severe pre-eclampsia among immigrant women: a mediation analysis. Scientific Reports. 2020 Mar; 10(1): 5215. doi: 10.1038/s41598-020-62032-9.

Emanuel M and Butt S. Frequency and factors leading to recurrent pre-eclampsia. The Journal of the Pakistan Medical Association. 2015 Nov; 65(11): 1173-7.

Soomro S, Kumar R, Lakhan H, Shaukat F. Risk factors for pre-eclampsia and eclampsia disorders in tertiary care center in Sukkur, Pakistan. Cureus. 2019 Nov; 11(11). doi: 10.7759/cureus.6115.

Wojtowicz A, Zembala-Szczerba M, Babczyk D, Kołodziejczyk-Pietruszka M, Lewaczyńska O, Huras H. Early- and late‐onset preeclampsia: a comprehensive cohort study of laboratory and clinical findings according to the new ISHHP criteria. International Journal of Hypertension. 2019; 2019(1): 4108271. doi: 10.1155/2019/4108271.

Gomathy E, Akurati L, Radhika K. Early onset and late onset preeclampsia-maternal and perinatal outcomes in a rural tertiary health center. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2018 May; 7(6): 2266. doi: 10.18203/2320-1770.ijrcog20182333.

Damayanti S, Sulistyowati S, Probandari AN. Maternal characteristics and the effects of early and late-onset types of preeclampsia on maternal and perinatal complications. Indonesian Journal of Medicine. 2019 Oct; 4(4): 329-38. doi: 10.26911/theijmed.v4i4.221.

Hegazy A, Eid FA, Ennab F, Sverrisdóttir YB, Atiomo W, Azar AJ. Prevalence of pre-eclampsia in women in the Middle East: a scoping review. Frontiers in Public Health. 2024 Aug; 12: 1384964. doi: 10.3389/fpubh.2024.1384964.

Li XL, Guo PL, Xue Y, Gou WL, Tong M, Chen Q. An analysis of the differences between early and late preeclampsia with severe hypertension. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 2016 Jan; 6(1): 47-52. doi: 10.1016/j.preghy.2015.12.003.

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Published

2025-06-30
CITATION
DOI: 10.54393/pjhs.v6i6.2987
Published: 2025-06-30

How to Cite

Bakht, F., Shahid, R., Afzal, M., Ashraf, K., Khalid, A., Hayat, A., & Hameed, S. (2025). Prevalence and Characteristics of Early vs. Late-Onset Preeclampsia: A Cross-Sectional Descriptive Study: Prevalence and Characteristics of Early vs. Late-Onset Preeclampsia. Pakistan Journal of Health Sciences, 6(6), 223–226. https://doi.org/10.54393/pjhs.v6i6.2987

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