Frequency of Hypoalbuminemia in Acute Ischemic Stroke Patients Presenting at Tertiary Care Hospital, Karachi
Frequency of Hypoalbuminemia in Acute Ischemic Stroke
DOI:
https://doi.org/10.54393/pjhs.v6i6.2967Keywords:
Hypoalbuminemia, Ischemic, Stroke, FrequencyAbstract
Stroke is regarded as the second most commonly reported death worldwide. The effect of albumin is mainly in the early reperfusion phase of acute ischemic stroke. Objective: To determine the frequency of hypoalbuminemia in patients with acute ischemic stroke. Methods: This cross-sectional observational study was carried out for six months (from April 2024 to October 2024) at the Department of Medicine, Al-Tibri Medical College, Karachi. 196 patients newly diagnosed with stroke patients presented within 24 hours were included, while patients with renal impairment, liver disease, etc., were excluded. SPSS version 24.0 was used for data analysis. Demographical data were reported with post-stratification chi-square applied, keeping p-value<0.05 as statistically significant. Results: A total of 196 patients with acute ischemic stroke were included in this study. The mean age in our study was 44.14 ± 4.49 years. 146 (74.5%) were male and 50 (25.5%) were female. Out of 196 acute ischemic stroke patients, 90 (45.9%) and 106 (54.1%) had and did not have hypoalbuminemia. Conclusions: It was concluded that a significant frequency of hypoalbuminemia was observed among patients presenting with acute ischemic stroke. However, association with stroke severity could not be established. Therefore, patients presenting with ischemic stroke ought to be screened for serum albumin levels when presenting to the hospital. In addition, patients with low serum albumin levels must be considered high risk and should be managed accordingly.
References
Machado MF, Brucki SM, Nogueira CF, Rocha MS. Infectious disease is the most common cause of death among stroke patients: two-years of follow-up. Arquivos De Neuro-Psiquiatria. 2013 Jun; 71(6): 371-5. doi: 10.1590/0004-282X20130041. DOI: https://doi.org/10.1590/0004-282X20130041
Alharbi AS, Alhayan MS, Alnami SK, Traad RS, Aldawsari MA, Alharbi SA et al. Epidemiology and risk factors of stroke. Archives of Pharmacy Practice. 2019; 10(4): 60-6. doi: 10.51847/pMfN3Q005M. DOI: https://doi.org/10.51847/pMfN3Q005M
Mendelson SJ and Prabhakaran S. Diagnosis and management of transient ischemic attack and acute ischemic stroke: a review. Journal of the American Medical Association. 2021 Mar; 325(11): 1088-98. doi: 10.1001/jama.2020.26867. DOI: https://doi.org/10.1001/jama.2020.26867
Powers WJ. Acute Ischemic Stroke. New England Journal of Medicine. 2020 Jul; 383(3): 252-60. doi: 10.1056/NEJMcp1917030. DOI: https://doi.org/10.1056/NEJMcp1917030
Ekkert A, Šliachtenko A, Grigaitė J, Burnytė B, Utkus A, Jatužis D. Ischemic stroke genetics: what is new and how to apply it in clinical practice?. Genes. 2021 Dec; 13(1): 48. doi: 10.3390/genes13010048. DOI: https://doi.org/10.3390/genes13010048
Zhou H, Wang A, Meng X, Lin J, Jiang Y, Jing J et al. Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack. Stroke and Vascular Neurology. 2021 Sep; 6(3). doi: 10.1136/svn-2020-000676. DOI: https://doi.org/10.1136/svn-2020-000676
Arques S. Human serum albumin in cardiovascular diseases. European Journal of Internal Medicine. 2018 Jun; 52: 8-12. doi: 10.1016/j.ejim.2018.04.014. DOI: https://doi.org/10.1016/j.ejim.2018.04.014
Li J, Imano H, Yamagishi K, Cui R, Muraki I, Umesawa M et al. Serum albumin and risks of stroke and its subtypesthe circulatory risk in communities study (CIRCS). Circulation Journal. 2021 Mar; 85(4): 385-92. doi: 10.1253/circj.CJ-20-0384. DOI: https://doi.org/10.1253/circj.CJ-20-0384
Bender M, Haferkorn K, Tajmiri-Gondai S, Stein M, Uhl E. Serum urea-to-albumin ratio is an independent predictor of Intra-hospital Mortality in Neurosurgical Intensive Care Unit patients with spontaneous intracerebral hemorrhage. Journal of Clinical Medicine. 2023 May 18; 12(10): 3538. doi: 10.3390/jcm12103538. DOI: https://doi.org/10.3390/jcm12103538
Bucci T, Pastori D, Pignatelli P, Ntaios G, Abdul-Rahim AH, Violi F et al. Albumin levels and risk of early cardiovascular complications after ischemic stroke: a propensity-matched analysis of a global federated health network. Stroke. 2024 Mar; 55(3): 604-12. doi: 10.1161/STROKEAHA.123.044248. DOI: https://doi.org/10.1161/STROKEAHA.123.044248
Aboud HN, Mohammed HA, Kamil MM, Hassan B. The Significance of Hypoalbumineamia and Hypoproteinemia in Patients with Stroke. Neuroscience and Medicine. 2018 Aug; 9(3): 105-15. doi: 10.4236/nm.2018.93011. DOI: https://doi.org/10.4236/nm.2018.93011
Ronit A, Kirkegaard-Klitbo DM, Dohlmann TL, Lundgren J, Sabin CA, Phillips AN et al. Plasma albumin and incident cardiovascular disease: results from the CGPS and an updated meta-analysis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Feb; 40(2): 473-82. doi: 10.1161/ATVBAHA.119.313681. DOI: https://doi.org/10.1161/ATVBAHA.119.313681
Javid RA, Bhatti A, Azhar MA. Frequency of Hypoalbuminemia in patients with Ischemic Stroke. Pakistan Journal of Medical Health Science. 2016 Apr; 10(2): 571-73.
Vahedi A, Lotfinia I, Sad RB, Halimi M, Baybordi H. Relationship between admission hypoalbuminemia and inhospital mortality in acute stroke. Pakistan Journal of Biological Sciences. 2011 Jan; 14(2): 118-22. doi: 10.3923/pjbs.2011.118.122. DOI: https://doi.org/10.3923/pjbs.2011.118.122
Wiedermann CJ. Hypoalbuminemia as surrogate and culprit of infections. International Journal of Molecular Sciences. 2021 Apr; 22(9): 4496. doi: 10.3390/ijms22094496. DOI: https://doi.org/10.3390/ijms22094496
Dziedzic T, Pera J, Slowik A, Gryz-Kurek EA, Szczudlik A. Hypoalbuminemia in acute ischemic stroke patients: frequency and correlates. European Journal of Clinical Nutrition. 2007 Nov; 61(11): 1318-22. doi: 10.1038/sj.ejcn.1602643. DOI: https://doi.org/10.1038/sj.ejcn.1602643
Moramarco S, Morciano L, Morucci L, Messinese M, Gualtieri P, Carestia M et al. Epidemiology of hypoalbuminemia in hospitalized patients: a clinical matter or an emerging public health problem?. Nutrients. 2020 Nov; 12(12): 3656. doi: 10.3390/nu12123656. DOI: https://doi.org/10.3390/nu12123656
Haq EU, Qayyum A, Qayyum HA, Anam MU, Khan AR, Ahmed KA, SHAFIQ F. Frequency of Hypoalbuminemia in Acute Ischemic Stroke patients Based on Stroke Severity. Pakakistan Journal of Medical Health Science. 2021; 15(6): 1335-9. doi: 10.53350/pjmhs211561335. DOI: https://doi.org/10.53350/pjmhs211561335
Abubakar S, Sabir A, Ndakotsu M, Imam M, Tasiu M. Low admission serum albumin as prognostic determinant of 30-day case fatality and adverse functional outcome following acute ischemic stroke. Pan African Medical Journal. 2013 May; 14(1). doi: 10.11604/pamj.2013.14.53.1941. DOI: https://doi.org/10.11604/pamj.2013.14.53.1941
Zhang Q, Lei YX, Wang Q, Jin YP, Fu RL, Geng HH et al. Serum albumin level is associated with the recurrence of acute ischemic stroke. The American Journal of Emergency Medicine. 2016 Sep; 34(9): 1812-6. doi: 10.1016/j.ajem.2016.06.049. DOI: https://doi.org/10.1016/j.ajem.2016.06.049
James R, Antony J, Sreedhar S, Mathew R, Surendran A. Study of serum albumin as a predictor of short-term functional outcome in acute ischaemic stroke. Journal of Evolution of Medical and Dental Sciences. 2017 May; 6(36): 2957-62. doi: 10.14260/Jemds/2017/637. DOI: https://doi.org/10.14260/Jemds/2017/637
Elbaih AH, Elshaboury IM, Ahmed RM, Abd Allah MA. Validity and prognostic value of serum albumin level in emergency acute ischemic stroke egyptian patients. Medicine. 2018; 7(4): 736-44. doi: 10.5455/medscience.2018.07.8844. DOI: https://doi.org/10.5455/medscience.2018.07.8844
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