Ankle-Brachial Pressure Index Correlates with Abdominal Volume Index in Normal-Weight Type 2 Diabetes Mellitus Patients
Role of ABPI and ABV in T2DM
DOI:
https://doi.org/10.54393/pjhs.v6i1.2660Keywords:
Obesity, Glycemic, Normal Weight, T2 Diabetes MellitusAbstract
Obesity significantly impacts glycemic control and vascular health in Type 2 diabetes mellitus. Objectives: To compare clinical characteristics, obesity indices, and vascular status between normal-weight and obese/overweight Type 2 diabetes mellitus patients. Methods: A cross-sectional study was conducted for six months from April 2024 to September 2024 at the Medicine Outpatient Department. This study included 82 Type 2 diabetes mellitus patients divided into two groups: normal-weight (n=34) and obese/overweight (n=48). Clinical parameters such as HbA1c, BMI, abdominal volume index, and ankle-brachial pressure index (ABPI) were measured. Data were analyzed by SPSS version 23.0. Results: Obese/overweight patients were significantly older (57.74 ± 8.57 vs. 52.81 ± 9.41 years, p=0.018) and had worse glycemic control (HbA1c: 7.17 ± 0.97% vs. 6.51 ± 0.68%, p = 0.0008) than normal-weight patients. Both BMI (30.57 ± 3.39 vs. 23.13 ± 1.80 kg/m²) and AVI (16.44 ± 1.58 vs. 11.84 ± 1.61) were higher in the obese/overweight group (both p<0.0001). Ankle-Brachial Pressure Index was lower in obese/overweight patients (0.93 ± 0.15 vs. 0.99 ± 0.08, p=0.033), suggesting poorer vascular health. Negative correlations between ankle-brachial pressure index and obesity indices indicated higher adiposity was linked to vascular dysfunction. Conclusions: It was concluded that obese/overweight Type 2 diabetes mellitus patients showed poorer vascular health and glycemic control than normal-weight patients. Abdominal volume index, age, and diabetes duration independently predicted ankle-brachial pressure index, emphasizing the need to address abdominal obesity and glycemic control to mitigate vascular risks in T2 diabetes mellitus patients.
References
Tanase DM, Gosav EM, Costea CF, Ciocoiu M, Lacatusu CM, Maranduca MA et al. The Intricate Relationship Between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD). Journal of Diabetes Research. 2020; 2020(1): 3920196. doi: 10.1155/2020/3920196. DOI: https://doi.org/10.1155/2020/3920196
Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB et al. Pathophysiology of Type 2 Diabetes Mellitus. International Journal of Molecular Sciences. 2020 Aug; 21(17): 6275. doi: 10.3390/ijms21176275. DOI: https://doi.org/10.3390/ijms21176275
Bellary S, Kyrou I, Brown JE, Bailey CJ. Type 2 Diabetes Mellitus in Older Adults: Clinical Considerations and Management. Nature Reviews Endocrinology. 2021 Sep; 17(9): 534-48. doi: 10.1038/s41574-021-00512-2. DOI: https://doi.org/10.1038/s41574-021-00512-2
Li Z, Cheng Y, Wang D, Chen H, Chen H, Ming WK, Wang Z. Incidence Rate of Type 2 Diabetes Mellitus After Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis of 170,139 Women. Journal of Diabetes Research. 2020; 2020(1): 3076463. doi: 10.1155/2020/3076463. DOI: https://doi.org/10.1155/2020/3076463
Artasensi A, Pedretti A, Vistoli G, Fumagalli L. Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs. Molecules. 2020 Apr; 25(8): 1987. doi: 10.3390/molecules25081987. DOI: https://doi.org/10.3390/molecules25081987
Yaribeygi H, Sathyapalan T, Atkin SL, Sahebkar A. Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus. Oxidative Medicine and Cellular Longevity. 2020; 2020(1): 8609213. doi: 10.1155/2020/8609213. DOI: https://doi.org/10.1155/2020/8609213
Kumar R, Saha P, Kumar Y, Sahana S, Dubey A, Prakash O. A Review On Diabetes Mellitus: Type1 and Type2. World Journal of Pharmacy and Pharmaceutical Sciences. 2020 Aug; 9(10): 838-50. doi: 10.20959/wjpps202010-17336.
Magkos F, Hjorth MF, Astrup A. Diet and Exercise in the Prevention and Treatment of Type 2 Diabetes Mellitus. Nature Reviews Endocrinology. 2020 Oct; 16(10): 545-55. doi: 10.1038/s41574-020-0381-5. DOI: https://doi.org/10.1038/s41574-020-0381-5
Mekala KC, Bertoni AG. Epidemiology of Diabetes Mellitus. In Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas. 2020 Jan: 49-58. doi: 10.1016/B978-0-12-814833-4.00004-6. DOI: https://doi.org/10.1016/B978-0-12-814833-4.00004-6
Argarini R, McLaughlin RA, Joseph SZ, Naylor LH, Carter HH, Haynes A et al. Visualizing and Quantifying Cutaneous Microvascular Reactivity in Humans By Use of Optical Coherence Tomography: Impaired Dilator Function in Diabetes. American Journal of Physiology-Endocrinology and Metabolism. 2020 Nov; 319(5): E923-31. doi: 10.1152/ajpendo.00233.2020. DOI: https://doi.org/10.1152/ajpendo.00233.2020
Perks J, Zaccardi F, Rayt H, Sayers R, Brady EM, Davies MJ et al. Device-Measured Physical Activity Behaviours, and Physical Function, in People with Type 2 Diabetes Mellitus and Peripheral Artery Disease: A Cross-Sectional Study. Experimental Gerontology. 2023 Jul; 178: 112207. doi: 10.1016/j.exger.2023.112207. DOI: https://doi.org/10.1016/j.exger.2023.112207
Twiddy HM. The Associations of Cardiovascular Disease, Physical Activity Intensities, and Measures of Obesity on Static Balance in Middle-Aged and Older Adults (Doctoral dissertation, Old Dominion University). 2022.
Ruze R, Liu T, Zou X, Song J, Chen Y, Xu R et al. Obesity and Type 2 Diabetes Mellitus: Connections in Epidemiology, Pathogenesis, And Treatments. Frontiers in Endocrinology. 2023 Apr; 14: 1161521. doi: 10.3389/fendo.2023.1161521. DOI: https://doi.org/10.3389/fendo.2023.1161521
Abdel-Galeel A, Magdy D, Helmy HA, Youssef AA, Ibrahim A. Correlation Between Ankle–Brachial Index, Wall Motion Score Index, and SYNTAX Score in Acute Coronary Syndrome Patients. Romanian Journal of Cardiology. 2022 Mar; 32(1): 14-21. doi: 10.2478/rjc-2022-0011. DOI: https://doi.org/10.2478/rjc-2022-0011
Sharma M, Bhatnagar M, Meelu A, Patel R, Uppal S. Prediction of Coronary Artery Disease Using Ankle Brachial Pressure Index in Patients with Diabetes Mellitus: A Cross-sectional Study. Journal of Clinical and Diagnostic Research. 2023 Apr; 17(4): OC01-5. doi: 10.7860/JCDR/2023/61591.17657. DOI: https://doi.org/10.7860/JCDR/2023/61591.17657
Mahé G, Aboyans V, Cosson E, Mohammedi K, Sarlon-Bartoli G, Lanéelle D et al. Challenges and Opportunities in the Management of Type 2 Diabetes in Patients with Lower Extremity Peripheral Artery Disease: A Tailored Diagnosis And Treatment Review. Cardiovascular Diabetology. 2024 Jun; 23(1): 220. doi: 10.1186/s12933-024-02325-9. DOI: https://doi.org/10.1186/s12933-024-02325-9
Chase-Vilchez AZ, Chan IH, Peters SA, Woodward M. Diabetes as A Risk Factor for Incident Peripheral Arterial Disease in Women Compared to Men: A Systematic Review and Meta-Analysis. Cardiovascular Diabetology. 2020 Dec; 19: 1-1. doi: 10.1186/s12933-020-01130-4. DOI: https://doi.org/10.1186/s12933-020-01130-4
Ranjan P, Sarvottam K, Yadav U. Association Between Modified Ankle-Brachial Pressure Index and Indices of Adiposity. Indian Journal of Physiology and Pharmacology. 2021 Jun; 65(1): 21-7. doi: 10.25259/IJPP_206_2020. DOI: https://doi.org/10.25259/IJPP_206_2020
Wu L, Zhu W, Qiao Q, Huang L, Li Y, Chen L. Novel and Traditional Anthropometric Indices for Identifying Metabolic Syndrome in Non-Overweight/Obese Adults. Nutrition and Metabolism. 2021 Dec; 18: 1-0. doi: 10.1186/s12986-020-00536-x. DOI: https://doi.org/10.1186/s12986-020-00536-x
Chiu TH, Huang YC, Chiu H, Wu PY, Chiou HY, Huang JC, Chen SC. Comparison of Various Obesity-Related Indices for Identification of Metabolic Syndrome: A Population-Based Study from Taiwan Biobank. Diagnostics. 2020 Dec; 10(12): 1081. doi: 10.3390/diagnostics10121081. DOI: https://doi.org/10.3390/diagnostics10121081
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