Effect of Maternal Nutrition and Micronutrient Supplementation on Neonatal Birth Weight and Health: Maternal Nutrition and Neonatal Health

Sanodia Afridi; Sana Rehman Joya; Bela Inayat; Sara Mariyum; Ommia Kalsoom; Hajra Imtiaz

doi:10.54393/pjhs.v6i3.2905

Authors

Sanodia Afridi Department of Obstetrics and Gynaecology, Health Net Hospital, Peshawar, Pakistan
Sana Rehman Joya Department of Community Health Sciences, Peshawar Medical College, Peshawar, Pakistan
Bela Inayat Department of Biochemistry, Khyber Girls Medical College, Peshawar, Pakistan
Sara Mariyum Department of Biochemistry, Swat Medical College, Swat, Pakistan
Ommia Kalsoom Department of Physiology, Women Medical College, Abbottabad, Pakistan
Hajra Imtiaz Department of Medical Education, Muhammad College of Medicine, Peshawar, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i3.2905

Keywords:

Maternal Nutrition, Micronutrient Supplementation, Neonatal Birth Weight, Neonatal Morbidity, Pregnancy Outcomes

Abstract

Maternal nutrition significantly influences fetal growth, birth weight, and neonatal health. Deficiencies in iron, calcium, folic acid, and vitamin D increase the risks of preterm birth, low birth weight, and neonatal complications. Objective: To assess the impact of maternal micronutrient supplementation on neonatal birth weight and health outcomes. Methods: A quasi experimental study was conducted at Health Net Hospital, Peshawar. A total of 110 pregnant women were recruited (59 supplemented, 51 non-supplemented). Data on maternal dietary intake, weight gain, and micronutrient consumption were collected. Neonatal birth weight, gestational age, NICU admissions, and morbidity were recorded. Statistical analysis was performed using SPSS version 25.0, with independent t-tests and chi-square tests (p<0.05 considered significant). Results: Neonates in the supplemented group had significantly higher birth weights (3343.54 ± 407.90 g vs. 2825.63 ± 322.46 g, p<0.001). NICU admissions were lower in the supplemented group (6.8% vs. 43.1%, p<0.001). Neonatal morbidity, including infections, jaundice, and respiratory distress, was significantly lower in the supplemented group (p<0.001). Conclusions: Micronutrient supplementation during pregnancy improves neonatal birth weight and reduces neonatal morbidity. These findings highlight the need for targeted maternal nutrition strategies to improve neonatal outcomes, particularly in resource-limited settings.

References

Mehta SH. Nutrition and pregnancy. Clinical Obstetrics and Gynecology. 2008 Jun; 51(2): 409-18. doi: 10.1097/GRF.0b013e31816fda53. DOI: https://doi.org/10.1097/GRF.0b013e31816fda53

Monfared, Z. The Importance of Nutrition for Fetal Health. Japanese Journal of Medical Science, 2024; 2(1): p. 1-8. doi: 10.33140/JJMS/02/01/0001.

Uberos J, Jimenez-Montilla S, Machado-Casas I, Laynez-Rubio C, Fernández-Marin E, Campos-Martínez A. The association between restricted intra-uterine growth and inadequate postnatal nutrition in very-low-birth-weight infants and their neurodevelopmental outcomes: a 50-month follow-up study. British Journal of Nutrition. 2022 Feb; 127(4): 580-8. doi: 10.1017/S000711452100132X. DOI: https://doi.org/10.1017/S000711452100132X

Sajid I, Khan SA, Hussain S, Rehman MU, Adnan MS. Maternal Nutrition and Its Impact on Low Birth Weight in Newborns. Indus Journal of Bioscience Research. 2025 Jan; 3(1): 236-44. doi: 10.70749/ijbr.v3i1.482. DOI: https://doi.org/10.70749/ijbr.v3i1.482

Lassi ZS, Padhani ZA, Rabbani A, Rind F, Salam RA, Bhutta ZA. Effects of nutritional interventions during pregnancy on birth, child health and development outcomes: A systematic review of evidence from low‐and middle‐income countries. Campbell Systematic Reviews. 2021 Jun; 17(2): e1150. doi: 10.1002/cl2.1150. DOI: https://doi.org/10.1002/cl2.1150

Krishnananda P, Dastidar RG, Rao AA, Rao M, Varashree BS. Micronutrients in Adverse Pregnancy Outcomes. F1000Research. 2024; 11. doi: 10.12688/f1000research.124960.4. DOI: https://doi.org/10.12688/f1000research.124960.4

Qin Y and Xie L. Nutrition and supplements during pregnancy: a vital component in building the health and well-being of both the mother and the developing baby. Nutrients. 2023 Jul; 15(15): 3395. doi: 10.3390/nu15153395. DOI: https://doi.org/10.3390/nu15153395

Wang D, Liu E, Perumal N, Partap U, Cliffer IR, Costa JC et al. The effects of prenatal multiple micronutrient supplementation and small-quantity lipid-based nutrient supplementation on small vulnerable newborn types in low-income and middle-income countries: a meta-analysis of individual participant data. The Lancet Global Health. 2025 Feb; 13(2): e298-308.

Kawai K, Spiegelman D, Shankar AH, Fawzi WW. Maternal multiple micronutrient supplementation and pregnancy outcomes in developing countries: meta-analysis and meta-regression. Bulletin of the World Health Organization. 2011; 89: 402-11. doi: 10.2471/BLT.10.083758. DOI: https://doi.org/10.2471/BLT.10.083758

González-Fernández D, Muralidharan O, Neves PA, Bhutta ZA. Associations of Maternal Nutritional Status and Supplementation with Fetal, Newborn, and Infant Outcomes in Low-Income and Middle-Income Settings: An Overview of Reviews. Nutrients. 2024 Oct; 16(21): 3725. doi: 10.3390/nu16213725. DOI: https://doi.org/10.3390/nu16213725

Cantor AG, Holmes R, Bougatsos C, Atchison C, DeLoughery T, Chou R. Screening and supplementation for iron deficiency and iron deficiency anemia during pregnancy: updated evidence report and systematic review for the US Preventive Services Task Force. Journal of the American Medical Association. 2024 Sep; 332(11): 914-28. doi: 10.1001/jama.2024.13546. DOI: https://doi.org/10.1001/jama.2024.13546

Mohammad NS, Nazli R, Zafar H, Fatima S. Effects of lipid based Multiple Micronutrients Supplement on the birth outcome of underweight pre-eclamptic women: A randomized clinical trial. Pakistan journal of medical sciences. 2022 Jan; 38(1): 219. doi: 10.12669/pjms.38.1.4396. DOI: https://doi.org/10.12669/pjms.38.1.4396

Grzeszczak K, Kapczuk P, Kupnicka P, Cecerska-Heryć E, Kwiatkowski S, Chlubek D et al. Calcium, potassium, sodium, and magnesium concentrations in the placenta, umbilical cord, and fetal membrane from women with multiple pregnancies. Life. 2023 Jan; 13(1): 153. doi: 10.3390/life13010153. DOI: https://doi.org/10.3390/life13010153

Boskabadi H, Maamouri G, Akhondian J, Ashrafzadeh F, Boskabadi A, Faramarzi R et al. Comparison of birth weights of neonates of mothers receiving vs. not receiving zinc supplement at pregnancy. BMC pregnancy and childbirth. 2021 Dec; 21: 1-7. doi: 10.1186/s12884-021-03598-8. DOI: https://doi.org/10.1186/s12884-021-03598-8

Marchant T, Alemayehu S, Asfaw E, Daba AK, Defar A, Opondo C et al. Effect of prenatal multiple micronutrient supplementation on birth weight in Ethiopia: protocol for a pragmatic cluster-randomised trial. BMJ open. 2025 Feb; 15(2): e093385. doi: 10.1136/bmjopen-2024-093385. DOI: https://doi.org/10.1136/bmjopen-2024-093385

Rai RK, De Neve JW, Geldsetzer P, Vollmer S. Maternal iron-and-folic-acid supplementation and its association with low-birth weight and neonatal mortality in India. Public Health Nutrition. 2022 Mar; 25(3): 623-33. doi: 10.1017/S1368980021004572. DOI: https://doi.org/10.1017/S1368980021004572

Emara MM. Correlation between Vitamin D Deficiency in Pregnancy and Low Birth Weight Neonates. The Medical Journal of Cairo University. 2022 Sep; 90(9): 1597-602. doi: 10.21608/mjcu.2022.271512. DOI: https://doi.org/10.21608/mjcu.2022.271512

Ilardi L, Proto A, Ceroni F, Morniroli D, Martinelli S, Mosca F et al. Overview of important micronutrients supplementation in preterm infants after discharge: a call for consensus. Life. 2021 Apr; 11(4): 331. doi: 10.3390/life11040331. DOI: https://doi.org/10.3390/life11040331

Jain S, Maheshwari A, Jain SK. Maternal nutrition and fetal/infant development. Clinics in Perinatology. 2022 Jun; 49(2): 313-30. doi: 10.1016/j.clp.2022.02.005. DOI: https://doi.org/10.1016/j.clp.2022.02.005

Alvestad S, Husebye ES, Christensen J, Dreier JW, Sun Y, Igland J et al. Folic acid and risk of preterm birth, preeclampsia, and fetal growth restriction among women with epilepsy: a prospective cohort study. Neurology. 2022 Aug; 99(6): e605-15. doi: 10.1212/WNL.0000000000200669. DOI: https://doi.org/10.1212/WNL.0000000000200669

Caniglia EC, Zash R, Swanson SA, Smith E, Sudfeld C, Finkelstein JL et al. Iron, folic acid, and multiple micronutrient supplementation strategies during pregnancy and adverse birth outcomes in Botswana. The Lancet Global Health. 2022 Jun; 10(6): e850-61. doi: 10.1016/S2214-109X(22)00126-7. DOI: https://doi.org/10.1016/S2214-109X(22)00126-7

Skinner AM and Narchi H. Preterm nutrition and neurodevelopmental outcomes. World Journal of Methodology. 2021 Nov; 11(6): 278. doi: 10.5662/wjm.v11.i6.278. DOI: https://doi.org/10.5662/wjm.v11.i6.278

Singh J, Kaur M, Rasane P, Kaur S, Kaur J, Sharma K et al. Nutritional management and interventions in complications of pregnancy: A systematic review. Nutrition and Health. 2023 May: 02601060231172545. doi: 10.1177/02601060231172545. DOI: https://doi.org/10.1177/02601060231172545

Cetin I, Devlieger R, Isolauri E, Obeid R, Parisi F, Pilz S et al. Maternal Nutrition Delphi Study Group, Steegers-Theunissen R. International expert consensus on micronutrient supplement use during the early life course. BioMed Central Pregnancy and Childbirth. 2025 Jan; 25(1):44. doi: 10.1186/s12884-024-07123-5. DOI: https://doi.org/10.1186/s12884-024-07123-5

Keats EC, Oh C, Chau T, Khalifa DS, Imdad A, Bhutta ZA. Effects of vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low‐and middle‐income countries: A systematic review. Campbell Systematic Reviews. 2021 Jun; 17(2): e1127. doi: 10.1002/cl2.1127. DOI: https://doi.org/10.1002/cl2.1127