Maternal Hyperuricemia in Normotensive Singleton Pregnancy, a Prenatal Finding with Continuous Perinatal and Postnatal Effects: Maternal Hyperuricemia in Normotensive Singleton Pregnancy

Hafiza Asifa Saleem; Sadia Zainab; Syeda Uzma; Naheed Hayat; Maheen Azhar; Nabila Shaheen

doi:10.54393/pjhs.v6i4.2727

Authors

Hafiza Asifa Saleem Department of Gynecology and Obstetrics, Combined Military Hospital, Bahawalpur, Pakistan
Sadia Zainab Department of Gynecology and Obstetrics, Combined Military Hospital, Bahawalpur, Pakistan
Syeda Uzma Department of Gynecology and Obstetrics, Combined Military Hospital, Bahawalpur, Pakistan
Naheed Hayat Department of Gynecology and Obstetrics, Combined Military Hospital, Bahawalpur, Pakistan
Maheen Azhar Department of Gynecology and Obstetrics, Combined Military Hospital, Bahawalpur, Pakistan
Nabila Shaheen Department of Gynecology and Obstetrics, Combined Military Hospital, Bahawalpur, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i4.2727

Keywords:

Maternal Hyperuricemia, Normotensive Pregnancy, Perinatal Outcomes, Singleton

Abstract

Maternal hyperuricemia has been associated with various adverse pregnancy outcomes in hypertensive disorders, but its effects in normotensive singleton pregnancies remain unclear. Objective: To assess the impact of maternal hyperuricemia on perinatal and postnatal outcomes in normotensive singleton pregnancies, with a focus on birth weight, gestational age, NICU admissions, and gestational anemia. Methods: This study was conducted at the Department of Obstetrics and Gynecology, Tertiary Care Hospital, Bahawalpur city, from 30-11-2022 to 29-06-2023. The Study Design was prospective observational cohort study. A cohort of normotensive pregnant women was prospectively followed to assess the association between maternal hyperuricemia and perinatal as well as postnatal outcomes. Results: Significant differences were observed in birth weight and gestational age between hyperuricemic and normouricemic mothers. Infants born to normourecemic mothers had higher birth weights (3.80 ± 0.35 kg vs. 3.51 ± 0.40 kg, p = 0.015) and were delivered earlier (38.50 ± 1.20 weeks vs. 39.35 ± 1.00 weeks, p = 0.025). Additionally, hyperuricemic mothers showed a higher prevalence of NICU admissions (42.9% vs. 26.5%, p = 0.035) and gestational anemia (42.9% vs. 19.1%, p = 0.043). Logistic regression revealed that maternal uric acid levels significantly influenced the likelihood of NICU admissions, suggesting a complex interaction with perinatal outcomes. Conclusions: Maternal hyperuricemia in normotensive singleton pregnancies significantly influences birth weight, gestational age at delivery, NICU admission rates, and the prevalence of gestational anemia, indicating a notable clinical impact in this population.

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