Maternal Hyperuricemia in Normotensive Singleton Pregnancy, a Prenatal Finding with Continuous Perinatal and Postnatal Effects
Maternal Hyperuricemia in Normotensive Singleton Pregnancy
DOI:
https://doi.org/10.54393/pjhs.v6i4.2727Keywords:
Maternal Hyperuricemia, Normotensive Pregnancy, Perinatal Outcomes, SingletonAbstract
Maternal hyperuricemia has been associated with various adverse pregnancy outcomes in hypertensive disorders, but its effects in normotensive singleton pregnancies remain unclear. Objective: To assess the impact of maternal hyperuricemia on perinatal and postnatal outcomes in normotensive singleton pregnancies, with a focus on birth weight, gestational age, NICU admissions, and gestational anemia. Methods: This study was conducted at the Department of Obstetrics and Gynecology, Tertiary Care Hospital, Bahawalpur city, from 30-11-2022 to 29-06-2023. The Study Design was prospective observational cohort study. A cohort of normotensive pregnant women was prospectively followed to assess the association between maternal hyperuricemia and perinatal as well as postnatal outcomes. Results: Significant differences were observed in birth weight and gestational age between hyperuricemic and normouricemic mothers. Infants born to normourecemic mothers had higher birth weights (3.80 ± 0.35 kg vs. 3.51 ± 0.40 kg, p = 0.015) and were delivered earlier (38.50 ± 1.20 weeks vs. 39.35 ± 1.00 weeks, p = 0.025). Additionally, hyperuricemic mothers showed a higher prevalence of NICU admissions (42.9% vs. 26.5%, p = 0.035) and gestational anemia (42.9% vs. 19.1%, p = 0.043). Logistic regression revealed that maternal uric acid levels significantly influenced the likelihood of NICU admissions, suggesting a complex interaction with perinatal outcomes. Conclusions: Maternal hyperuricemia in normotensive singleton pregnancies significantly influences birth weight, gestational age at delivery, NICU admission rates, and the prevalence of gestational anemia, indicating a notable clinical impact in this population.
References
Liu L, Yu C, Yang F, Yuan Z, Wang Q, Liu S et al. Maternal hyperuricemia superimposed on maternal hypertension aggravates the risk of small-for-gestational-age fetus. Life Sciences. 2019 Jul; 228: 215-20. doi: 10.1016/j.lfs.2019.04.033.
Bhatia N, Shanmugam R, Jain K, Sikka P, Verma I. Maternal hyperuricemia as a marker of post-spinal hypotension and uterine tone during cesarean delivery: a prospective observational study. Archives of Gynecology and Obstetrics. 2019 Oct; 300: 925-31. doi: 10.1007/s00404-019-05282-x.
Fischer RL, Weisberg LS, Hediger ML. Etiology of third-trimester maternal hyperuricemia in nonpreeclamptic twin gestations. Obstetrics & Gynecology. 2001 Jan; 97(1): 62-5. doi: 10.1097/00006250-200101000-00013.
Mehra D, Bhatia N, Jain K, Sikka P, Verma I, Singla K. Association of Maternal Hyperuricemia with Post-Spinal Hypotension in Pre-Eclamptic Parturients Undergoing Emergency Cesarean Delivery: a Prospective Observational Study. Reproductive Sciences. 2021 Feb; 28: 343-50. doi: 10.1007/s43032-020-00336-x.
Sedamkar MS and Pati VN. Hyperuricemia and maternal outcome in pregnancy induced hypertension: prospective study in a tertiary care center in Mumbai, India. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2023 May; 12(5): 1379-84. doi: 10.18203/2320-1770.ijrcog20231228.
Ilyas S, Khan FN, Halima A, Rehman F, Sarwar Z, Dawar A. Association of hyperuricemia with preeclampsia in second trimester of pregnancy. Journal of Population Therapeutics and Clinical Pharmacology. 2023. doi: 10.53555/jptcp.v30i7.5036.
Lüscher BP, Schoeberlein A, Surbek DV, Baumann MU. Hyperuricemia during pregnancy leads to a Preeclampsia-Like phenotype in mice. Cells. 2022 Nov; 11(22): 3703. doi: 10.3390/cells11223703.
Khalil S, ElShourbagy S, Hamad S, Abo Zeid E. Hyperuricemia as a predictor of perinatal outcomes in pregnancy induced hypertension. Journal of Obstetrics and Gynaecology Research. 2018 Dec; 5(1). doi: 10.17140/GOROJ-5-147.
Nizamani S, Hussain K, Kumar R, Sawai S, Singh D. Hyperuricemia in metabolic syndrome. The Professional Medical Journal. 2023 May; 30(05): 644-8. doi: 10.29309/TPMJ/2023.30.05.6963.
Roberts L, Henry A, Harvey SB, Homer CS, Davis GK. Depression, anxiety and posttraumatic stress disorder six months following preeclampsia and normotensive pregnancy: a P4 study. BioMed Central Pregnancy and Childbirth. 2022 Feb; 22(1): 108. doi: 10.1186/s12884-022-04439-y.
Blake BE and Fenton SE. Early life exposure to per-and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri-and postnatal effects. Toxicology. 2020 Oct; 443: 152565. doi: 10.1016/j.tox.2020.152565.
Conley JM, Lambright CS, Evans N, Strynar MJ, McCord J, McIntyre BS et al. Adverse maternal, fetal, and postnatal effects of hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague-Dawley rats. Environmental Health Perspectives. 2019 Mar; 127(3): 037008. doi: 10.1289/EHP4372.
Sosnowski DW, Ellison-Barnes A, Kaufman J, Hoyo C, Murphy SK, Hernandez RG et al. Financial stress as a mediator of the association between maternal childhood adversity and infant birth weight, gestational age, and NICU admission. BioMed Central Public Health. 2023 Mar; 23(1): 606. doi: 10.1186/s12889-023-15495-0.
Jasim SK, Al-Momen H, Al-Naddawi AM. Prediction of maternal diabetes and adverse neonatal outcome in normotensive pregnancy using serum uric acid. International Journal of Research in Pharmaceutical Sciences. 2019; 10(4): 3563-9. doi: 10.26452/ijrps.v10i4.1736.
Ponnapakkam A, Rees D, Gallup MC, Ahmad KA, Miller D, Fagiana A et al. Supplementation-based hypoglycemia guidelines including donor breast milk reduce NICU admission. Journal of Perinatology. 2021 Aug; 41(8): 2088-94. doi: 10.1038/s41372-021-01069-8.
Talisman S, Guedalia J, Farkash R, Avitan T, Srebnik N, Kasirer Y et al. NICU admission for term neonates in a large single-center population: a comprehensive assessment of risk factors using a tandem analysis approach. Journal of Clinical Medicine. 2022 Jul; 11(15): 4258. doi: 10.3390/jcm11154258.
Daise DT, Tasnim S, Yasmin N, Ahsan AB, Khanam W, Rahman M. Maternal Hyperuricemia and Birth Outcome in Normotensive Singleton Pregnancy: A Prospective Cohort Study. Journal of Medical Science And clinical Research. 2018;6(10).
Ural ÜM, Tekin YB, Kırbaş A, Şahin FK. Normotansif Gebelerde Maternal Kan Ürik Asit Değerlerinin Gestasyonel Yaş İle Karşılaştırılması. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2015 Mar; 12(2): 68-70.
Ajitkumar Y, Naorem S, Kshetrimayum V, Singh YU, Saha S, Devi PJ et al. Serum Uric Acid in Pre-eclampsia. International Journal of Innovative Research in Medical Science. 2019 Apr: 4(04). doi: 10.23958/ijirms/vol04-i04/617.
Mohamed ZAZ, Abd-Elraheem SE, Ebrahim NA, Mansour H, Gad NM. Asymmetric Dimethyl Arginine and Cell Free Total DNA as Diagnostic Markers in Preeclampsia. Clinical Medicine and Diagnostics. 2017.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Pakistan Journal of Health Sciences

This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments