Lactate Dehydrogenase as a Prognostic Biomarker in Severe Sepsis in Intensive Care Unit: Lactate Dehydrogenase as a Prognostic Biomarker in Severe Sepsis

Amir Bashir; Muhammad Rizwan Hafeez; Sibgha Bashir; Adeel Zafar; Naveed Nayyer; Sara Khan

doi:10.54393/pjhs.v6i2.1930

Authors

Amir Bashir Department of Medicine, Shahida Islam Medical Complex, Lodhran, Pakistan
Muhammad Rizwan Hafeez Department of Medicine, Shahida Islam Medical Complex, Lodhran, Pakistan
Sibgha Bashir Department of Pathology, Shahida Islam Medical Complex, Lodhran, Pakistan
Adeel Zafar Department of Medicine and Pathology, Shahida Islam Medical Complex, Lodhran, Pakistan
Naveed Nayyer Department of Medicine, Shahida Islam Medical Complex, Lodhran, Pakistan
Sara Khan CMH Institute of Medical Sciences, Bahawalpur, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i2.1930

Keywords:

Creatinine, Intensive Care Unit, Lactate Dehydrogenase, Mortality

Abstract

Sepsis ranks as one of the principal death-causing conditions in present-day society. The medical community identifies lactate dehydrogenase (LDH) as a potential tool to assess sepsis severity. Objectives: To assess how LDH blood concentrations relate to severe sepsis progression. Methods: A retrospective examination took place within the intensive care unit (ICU) at Shahida Islam Medical Complex. Data of patients of both genders, aged between 18-75 years, and who were admitted to the intensive care unit with sepsis. Biochemical data, including necessary laboratory investigations, infection areas, and comorbidities, were documented. The study subjects were analyzed concerning LDH ≤230 U/L (n=41) and LDH >230 U/L (n=55). Univariate Cox regression analysis for 21-day mortality was also carried out. Results: The records of 96 patients as per inclusion and exclusion criteria were considered for this study. There were 61 (63.5%) patients who were male. The overall mean age was 54.2 ± 12.6 years. LDH ≥230 U/L was found to have a significant association with findings that included significantly higher CRP (p=0.0001) and LDH levels (p=0.0001) in patients with LDH ≥230 U/L compared to LDH <230 U/L. A significant association high SOFA score (p=0.002), and APACHE-II score (p=0.001) was found with LDH≥230 U/L. Strong associations of the biochemical levels, which included LDH levels (HR=1.006, p=0.010), lactate levels (HR=1.498, p=0.002), and creatinine levels (HR=1.483, p=0.005) were seen with mortality. Conclusions: It was concluded that elevated LDH levels were associated with increased disease severity and adverse clinical outcomes, including higher mortality rates, in severe sepsis patients.

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