In-Hospital Mortality in Hyponatremia Patients Hospitalized for Heart Failure at National Institute of Cardiovascular Disease (N.I.C.V.D) Karachi

In-Hospital Mortality in Hyponatremia Patients

Authors

  • . Yasmeen Department of Cardiology, National Institute of Cardiovascular Disease NICVD, Karachi, Pakistan
  • . Sumaiya Department of Cardiology, National Institute of Cardiovascular Disease NICVD, Karachi, Pakistan
  • Fayaz Ali Department of Cardiology, National Institute of Cardiovascular Disease NICVD, Karachi, Pakistan
  • Muneeb Ali Department of Cardiology, National Institute of Cardiovascular Disease NICVD, Karachi, Pakistan
  • Nasreen Bano Department of Cardiology, National Institute of Cardiovascular Disease NICVD, Karachi, Pakistan
  • Asad Raza Department of Cardiology, National Institute of Cardiovascular Disease NICVD, Karachi, Pakistan
  • Adnan Fazal Department of Cardiology, National Institute of Cardiovascular Disease NICVD, Karachi, Pakistan
  • Jawaid Siyal Department of Cardiology, National Institute of Cardiovascular Disease NICVD, Karachi, Pakistan
  • Tahir Sagir Department of Cardiology, National Institute of Cardiovascular Disease NICVD, Karachi, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v4i06.809

Keywords:

Heart Failure, In-Hospital Mortality, Length of Hospital Stay (LOHS), Hyponatremic, Hospitalized Patients

Abstract

Heart failure is a clinical syndrome that appears when the heart either is unable to sustain a sufficient cardiac output or can only do so at the cost of an increased filling pressure. Hyponatremia is poor prognostic sign. Objective: To determine the frequency of in-hospital mortality in hyponatremic patients hospitalized for heart failure at National Institute of Cardiovascular Disease (N.I.C.V.D) Karachi. Methods: This cross sectional study was conducted at Department of Cardiology, NICVD, Karachi, Pakistan from 1st March 2018 to 31st August 2018. All patient who fulfilled the inclusion criteria were enrolled and consent was taken. All the patients were managed according to guidelines and followed during hospital stay for in-hospital mortality. Data were collected in proforma. Results: The in-hospital mortality was 13(9.09%). Lower admission serum sodium was associated with high mortality. Conclusions: Patients hospitalized with  heart failure frequently had hyponatremia, which was linked to greater in-hospital mortality. Severe hyponatremic patients have worse clinical outcomes

References

Zeltser D, Rosansky S, van Rensburg H, Verbalis JG, Smith N. Assessment of the efficacy and safety of intravenous conivaptan in euvolemic and hypervolemic hyponatremia. American Journal of Nephrology. 2007 Jul; 27: 447-57. doi: 10.1159/000106456. DOI: https://doi.org/10.1159/000106456

Konstam MA, Kiernan M, Chandler A, Dhingra R, Mody FV, Eisen H, et al. Short-term effects of tolvaptan in patients with acute heart failure and volume overload. Journal of the American College of Cardiology. 2017 Mar; 69(11): 1409-19. doi: 10.1016/j.jacc.2016.12.035. DOI: https://doi.org/10.1016/j.jacc.2016.12.035

Agarwal SK, Wruck L, Quibrera M, Matsushita K, Loehr LR, Chang PP, et al. Temporal trends in hospitalization for acute decompensated heart failure in the United States, 1998–2011. American Journal of Epidemiology. 2016 Mar; 183(5): 462-70. doi: 10.1093/aje/kwv455. DOI: https://doi.org/10.1093/aje/kwv455

Romanovsky A, Bagshaw S, Rosner MH. Hyponatremia and congestive heart failure: a marker of increased mortality and a target for therapy. International Journal of Nephrology. 2011 Apr; 2011: 732746. doi: 10.4061/2011/732746. DOI: https://doi.org/10.4061/2011/732746

De Vecchis R, Di Maio M, Di Biase G, Ariano C. Effects of hyponatremia normalization on the short-term mortality and rehospitalization in patients with recent acute decompensated heart failure: A retrospective study. Journal of Clinical Medicine. 2016 Oct; 5: 92. doi: 10.3390/jcm5100092. DOI: https://doi.org/10.3390/jcm5100092

Kazory A. Hyponatremia in heart failure: Revisiting pathophysiology and therapeutic strategies. Clinical Cardiology. 2010 Jun; 33: 322-9. doi: 10.1002/clc.20791. DOI: https://doi.org/10.1002/clc.20791

Ramos-Levi AM, Duran Rodriguez-Hervada A, Mendez-Bailon M, Marco-Martinez J. Drug-induced hyponatremia: An updated review. Minerva Endocrinology. 2014 Mar; 39: 1-12.

Liamis G, Milionis H, Elisaf M. A review of drug-induced hyponatremia. American Journal of Kidney Diseases. 2008 Jul; 52(1): 144-53. doi: 10.1053/j.ajkd.2008.03.004. DOI: https://doi.org/10.1053/j.ajkd.2008.03.004

Ahmad F, Hadi A, Iqbal MA, ullah Khan I, Adnan Y, Haq MR, et al. Frequency of hyponatremia and in-hospital clinical outcomes in these patients hospitalized for heart failure. Journal of Postgraduate Medical Institute. 2015 Jan; 28(4): 362-6.

Mohammed AA, van Kimmenade RR, Richards M, Bayes-Genis A, Pinto Y, Moore SA, et al. Hyponatremia, natriuretic peptides, and outcomes in acutely decompensated heart failure: results from the International Collaborative of NT-proBNP Study. Circulation: Heart Failure. 2010 May; 3(3): 354-61. doi: 10.1161/CIRCHEARTFAILURE.109.915280. DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.109.915280

Shepshelovich D, Schechter A, Calvarysky B, Diker-Cohen T, Rozen-Zvi B, Gafter-Gvili A. Medication-induced siadh: Distribution and characterization according to medication class. British Journal of Clinical Pharmacology. 2017 Jun; 83: 1801-7. doi: 10.1111/bcp.13256. DOI: https://doi.org/10.1111/bcp.13256

Uretsky BF, Verbalis JG, Generalovich T, Valdes A, Reddy PS. Plasma vasopressin response to osmotic and hemodynamic stimuli in heart failure. American Journal of Physiology. 1985 Mar; 248: H396-402. doi: 10.1152/ajpheart.1985.248.3.H396. DOI: https://doi.org/10.1152/ajpheart.1985.248.3.H396

Mendez GF and Cowie MR. The epidemiological features of heart failure in developing countries: a review of the literature. International Journal of Cardiology. 2001 Oct; 80: 213. doi: 10.1016/S0167-5273(01)00497-1. DOI: https://doi.org/10.1016/S0167-5273(01)00497-1

Diaconu CC and Bartoş DA. Frequency and outcomes of hyponatremic patients with heart failure hospitalized in the Clinical Emergency Hospital of Bucharest. Romanian Journal of Internal Medicine. 2014 Jan; 52(1): 24-6.

Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017. Cardiovascular Diabetology. 2018 Jun; 17(1): 83. doi: 10.1186/s12933-018-0728-6. DOI: https://doi.org/10.1186/s12933-018-0728-6

Triposkiadis F, Xanthopoulos A, Bargiota A, Kitai T, Katsiki N, Farmakis D, et al. Diabetes mellitus and heart failure. Journal of Clinical Medicine. 2021 Aug; 10(16): 3682. doi: 10.3390/jcm10163682. DOI: https://doi.org/10.3390/jcm10163682

Di Palo KE and Barone NJ. Hypertension and heart failure: prevention, targets, and treatment. Heart Failure Clinics. 2020 Jan; 16(1): 99-106. doi: 10.1016/j.hfc.2019.09.001. DOI: https://doi.org/10.1016/j.hfc.2019.09.001

Mullens W, Abrahams Z, Francis GS, Skouri HN, Starling RC, Young JB, et al. Sodium nitroprusside for advanced low-output heart failure. Journal of the American College of Cardiology. 2008 Jul; 52(3): 200-7. doi: 10.1016/j.jacc.2008.02.083. DOI: https://doi.org/10.1016/j.jacc.2008.02.083

Gheorghiade M, Abraham WT, Albert NM, Gattis Stough W, Greenberg BH, O'Connor CM, et al. Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry. European Heart Journal. 2007 Apr; 28(8): 980-8. doi: 10.1093/eurheartj/ehl542. DOI: https://doi.org/10.1093/eurheartj/ehl542

Klein L, O’Connor CM, Leimberger JD, Gattis-Stough W, Piña IL, Felker GM, et al. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure. Results from the outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure (OPTIME-CHF) study. Circulation. 2005 May; 111(19): 2454-60. doi: 10.1161/01.CIR.0000165065.82609.3D. DOI: https://doi.org/10.1161/01.CIR.0000165065.82609.3D

Downloads

Published

2023-06-30
CITATION
DOI: 10.54393/pjhs.v4i06.809
Published: 2023-06-30

How to Cite

Yasmeen, ., Sumaiya, ., Ali, F. ., Ali, M. ., Bano, N. ., Raza, A. ., Fazal, A., Siyal, J. ., & Sagir, T. . (2023). In-Hospital Mortality in Hyponatremia Patients Hospitalized for Heart Failure at National Institute of Cardiovascular Disease (N.I.C.V.D) Karachi: In-Hospital Mortality in Hyponatremia Patients. Pakistan Journal of Health Sciences, 4(06), 35–38. https://doi.org/10.54393/pjhs.v4i06.809

Issue

Section

Original Article

Plaudit