The Frequency of Hepatitis B and C and its Risk Factors in Pregnant Women Presenting at Jinnah Postgraduate Medical Center, Karachi

Hepatitis B and C and its Risk Factors in Pregnant Women

Authors

  • Shazia Naseeb Jinnah Post Graduate Medical Centre, Karachi, Pakistan
  • Shaista Rashid Karachi Medical Dental College, Karachi, Pakistan
  • Sania Dehar Jinnah Post Graduate Medical Centre, Karachi, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v4i03.561

Keywords:

Hepatitis B, Hepatitis C, Pregnancy, Dental Procedure, Blood Transfusion

Abstract

Hepatitis B and C are the most common infections throughout the world. Both viral infections in pregnancy have serious implications, including increasing the risk of chronic infection, perinatal transmission, accelerated liver damage. Objective: To identify the frequency of hepatitis B and C in pregnant women as well as the risk factors that contribute to these infections. Methods: A Cross-sectional study was conducted at Department of Gynecology and Obstetrics, Jinnah Postgraduate Medical Center (JPMC), Karachi from 10th July 2022 till 10th December 2022. After taking a verbal consent data were collected from 332 patients who met the diagnostic criteria. Quantitative data were presented as simple descriptive statistics using mean and standard deviation, whereas frequency and percentages were used for qualitative variables. Effect modifiers were controlled through stratification to see the effect of these on the outcome variable. chi square test was applied after stratification with p-value of ≤0.05 considered significant. Results: Mean age and gestational age was 33.41 ± 7.59 years and 38.24 ± 1.77 weeks respectively. Hepatitis B and C was found in 20.5% and 14.5% respectively. Most common risk factors are use of injections and various surgical procedure followed by blood transfusion, tattooing and multiple sexual partners is least common factors. Conclusions: The study indicated the high frequency of hepatitis B and C virus infection among pregnant women. HBV and HCV infection were associated with histories of injections, surgeries, and blood transfusions

References

Ahmad I. Prevalence of hepatitis B and C viral infection among pregnant women in Peshawar, Pakistan. Hepatitis Monthly 2016 Jun; 16 (6): e36383. doi: 10.5812/hepatmon.36383.

Bittaye M, Idoko P, Ekele BA, Obed SA, Nyan O. Hepatitis B virus sero-prevalence amongst pregnant women in the Gambia. BMC Infectious Diseases. 2019 Dec; 19(1): 1-8. doi: 10.1186/s12879-019-3883-9.

Noubiap JJ, Nansseu JR, Ndoula ST, Bigna JJ, Jingi AM, Fokom-Domgue J. Prevalence, infectivity and correlates of hepatitis B virus infection among pregnant women in a rural district of the Far North Region of Cameroon. BMC Public Health. 2015 Dec;15(1): 1-7. doi: 10.1186/s12889-015-1806-2.

Abongwa LE and Kenneth P. Assessing prevalence and risk factors of hepatitis B surface antigen amongst pregnant women attending antenatal clinic in the Northwest Region of Cameroon. European Journal of Research in Medical Sciences. 2016; 4(1): 32-43.

Bigna JJ, Amougou MA, Asangbeh SL, Kenne AM, Noumegni SR, Ngo-Malabo ET, et al. Seroprevalence of hepatitis B virus infection in Cameroon: a systematic review and meta-analysis. BMJ Open. 2017 Jun; 7(6): e015298. doi: 10.1136/bmjopen-2016-015298.

Eyong EM, Yankam BM, Seraphine E, Ngwa CH, Nkfusai NC, Anye CS, et al. The prevalence of HBsAg, knowledge and practice of hepatitis B prevention among pregnant women in the Limbe and Muyuka Health Districts of the South West region of Cameroon: a three-year retrospective study. Pan African Medical Journal. 2019 Mar; 32(1): 1-11. doi: 10.11604/pamj.2019.32.122.16055.

Demeke G, Ayalneh GM, Shiferaw AA, Toru M, Dilnessa T. Sero-prevalence and associated factors of hepatitis B virus among pregnant women at north West Ethiopia: an institution-based cross-sectional study. International Journal of General Medicine. 2021 Jun; 14: 2799-805. doi: 10.2147/IJGM.S320711.

Kuncio DE, Newbern EC, Johnson CC, Viner KM. Failure to test and identify perinatally infected children born to hepatitis C virus–infected women. Clinical Infectious Diseases. 2016 Apr; 62(8): 980-5. doi: 10.1093/cid/ciw026.

Bittaye M, Idoko P, Ekele BA, Obed SA, Nyan O. Hepatitis B virus sero-prevalence amongst pregnant women in the Gambia. BMC Infectious Diseases. 2019 Dec; 19(1): 1-8. doi: 10.1186/s12879-019-3883-9.

World Health Organization. Guidelines for the prevention care and treatment of persons with chronic hepatitis B infection: Mar-15. World Health Organization; 2015 Aug.

Sievert W, Altraif I, Razavi HA, Abdo A, Ahmed EA, AlOmair A, et al. systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. Liver International. 2011 Jul; 31: 61-80. doi: 10.1111/j.1478-3231.2011.02540.x.

Qureshi H, Mohamud BK, Alam SE, Arif A, Ahmed W. Treatment of hepatitis B and C through national programme-an audit. Journal of Pakistan Medical Association. 2013 Feb; 63(2): 220-4.

Ruiz-Extremera Á, Diaz-Alcazar MD, Muñoz-Gámez JA, Cabrera-Lafuente M, Martin E, Arias-Llorente RP, et al. Seroprevalence and epidemiology of hepatitis B and C viruses in pregnant women in Spain.Risk factors for vertical transmission. PLoS One. 2020 May; 15(5): e0233528. doi: 10.1371/journal.pone.0233528.

Nlinwe NO and Lungle D. Risk factors associated with hepatitis B virus infection among pregnant women attending the antenatal care unit of the Bamenda Regional Hospital. Public Health in Practice. 2021 Nov; 2: 100160. doi: 10.1016/j.puhip.2021.100160.

Kumari K, Seetlani NK, Akhter R. The emergent concern of seropositive status of hepatitis-B virus and hepatitis-C virusin the pregnant females attending a Tertiary Care Hospital. Journal of Ayub Medical College Abbottabad. 2015 Mar; 27(1): 155–7.

Tanveer Z, Ahmad I, Javed MS, Malik SA, Kakar NH, Ahmad M, et al. Screening for hepatitis b and c viral infections among pregnant women attending the Bolan Medical Complex Hospital and Sandeman Provincial Civil Hospital Quetta, Pakistan. The Professional Medical Journal. 2020 Jul; 27(07): 1328-34. doi: 10.29309/TPMJ/2020.27.08.3129.

Mushtaq S and Razzaque AR. Prevalance of HBV & HCV Infection in Faisalabad. Biomedica. 2017 May; 26(1): 76-9.

Cetin S, Cetin M, Turhan E, Dolapcioglu K. Seroprevalence of hepatitis B surface antigen and associated risk factors among pregnant women. The Journal of Infection in Developing Countries. 2018 Oct; 12(10): 904-9. doi: 10.3855/jidc.10018.

Sheng QJ, Wang SJ, Wu YY, Dou XG, Ding Y. Hepatitis B virus serosurvey and awareness of mother-to-child transmission among pregnant women in Shenyang, China: An observational study. Medicine. 2018 Jun; 97(22): e10931. doi: 10.1097/MD.0000000000010931.

Chotun N, Preiser W, van Rensburg CJ, Fernandez P, Theron GB, Glebe D, et al. Point-of-care screening for hepatitis B virus infection in pregnant women at an antenatal clinic: A South African experience. Jhaveri R, editor. PLOS ONE. 2017 Jul; 12(7): e0181267. doi: 10.1371/journal.pone.0181267.

Kishk R, Mandour M, Elprince M, Salem A, Nemr N, Eida M, et al. Pattern and interpretation of hepatitis B virus markers among pregnant women in North East Egypt. Brazilian Journal of Microbiology. 2020 Jun; 51: 593-600. doi: 10.1007/s42770-019-00174-3.

Arshad A and Ashfaq UA. Epidemiology of hepatitis C infection in Pakistan: current estimate and major risk factors. Critical Reviews™ in Eukaryotic Gene Expression. 2017; 27(1): 63-77. doi: 10.1615/CritRevEukaryotGeneExpr.2017018953.

Bint Ali S, Izhar M, Lal C, Yaqoob A, tul Hafsa H, Akram A. Frequency of Occult Hepatitis B in Pregnant Women Attending Antenatal Care Unit of a Tertiary Care Hospital. InProceedings 2020 Jan; 34(4): 10-5. doi: 10.47489/p000s344z764mc.

World Health Organization. Combating hepatitis B and C to reach elimination by 2030: advocacy brief. World Health Organization; 2016 May. [Last Cited: 6th Mar 2023] Available at: https://apps.who.int/iris/bitstream/handle/10665/206453/WHO_HIV_2016.04_eng.pdf

Jilani K, Zulfiqar B, Memon QB, Fahim MF. Frequency and the risk factors of hepatitis C virus in pregnant women; A hospital based descriptive study in Gadap Town Karachi. Pakistan Journal of Medical Sciences. 2017 Sep; 33(5): 1265. doi: 10.12669/pjms.335.12493.

Mekonnen R, Admasu D, Belete M. Sero-Prevalence of Hepatitis B Virus and associated factors among pregnant mothers attending antenatal care in Public Health Facilities, Dire Dawa. Journal of Medical Microbiology & Diagnosis. 2018; 7(281): 1-8. doi: 10.4172/2161-0703.1000281.

Mobarki AA, Madkhali MM, Dobie G, Saboor M, Madkhali AM, Madkhli B, et al. Patterns of Hepatitis B, Hepatitis C and HIV Among Blood Donors in Samtah-Jazan Region. Journal of Epidemiology and Global Health. 2022 Sep; 12(3): 304-10. doi: 10.1007/s44197-022-00051-7.

Saleem U, Aslam N, Siddique R, Iqbal S, Manan M. Hepatitis C virus: Its prevalence, risk factors and genotype distribution in Pakistan. European Journal of Inflammation. 2022 Nov; 20: 1721727X221144391. doi: 10.1177/1721727X221144391

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Published

2023-03-31
CITATION
DOI: 10.54393/pjhs.v4i03.561
Published: 2023-03-31

How to Cite

Naseeb, S. ., Rashid, S., & Dehar, S. . (2023). The Frequency of Hepatitis B and C and its Risk Factors in Pregnant Women Presenting at Jinnah Postgraduate Medical Center, Karachi: Hepatitis B and C and its Risk Factors in Pregnant Women. Pakistan Journal of Health Sciences (Lahore), 4(03), 83–87. https://doi.org/10.54393/pjhs.v4i03.561

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