Incidence of Hepatitis B Due to Multiple Transfusions in Patients of β-Thalassemia Major

Incidence of Hepatitis B in Patients of β-Thalassemia Major


  • Rida Naz Regional Blood Centre, Dera Ismail Khan, Pakistan
  • Farman Ullah Department of Pediatrics, Gomal Medical College, Dera Ismail Khan, Pakistan
  • Taj Muhammad Department of Pediatrics, Gomal Medical College, Dera Ismail Khan, Pakistan
  • Obidullah Khan District Head Quarter Hospital SWTD Wana, Wana, Pakistan
  • Faridullah Shah Department of Biochemistry, Pak International Medical College, Peshawar, Pakistan
  • Aziz u Rehman Department of Biochemistry, Rehman Medical College, Peshawar, Pakistan
  • Noor Ul Basir District Head Quarter Hospital SWTD Wana, Wana, Pakistan



Chronic illness, Hepatitis B, Immunization, Thalassemia


β-Thalassemia is one of the most prevalent childhood hemolytic disorders. Multiple blood transfusions of unscreened blood can result in infection transmission. After many transfusions, Hepatitis B infection in thalassemia patients was reported. Objective: To determine the incidence of Hepatitis B in β-thalassemia major patients, associated with multiple blood transfusion strategies. Methods: This cross-sectional study was executed in Pediatric department of DHQ teaching hospital Dera Ismail khan with the collaboration of the Regional Blood center, and comprised 360 patients, diagnosed with β-Thalassemia Major and maintained on multiple transfusions. Results: The average weight of the subjects was 43.50+18.76 Kg and their mean age was 13.10+2.1 years. The significantly high population of the patients (p<0.05) was not immunized against Hepatitis B (73.88%), while only 26.66% (94/360) were immunized. The patients having less than 10, 11-20 and more than 20 transfusions per annum comprised 72 (20%), 157 (43.61%) and 131 (36.38%) patients, respectively. The affected patients had significantly altered hematological parameters (p<0.05). The highest number of β-Thalassemia Major patients affected with Hepatitis B belonged to the Group having more than 25 transfusions of blood annually, with an incidence rate of 11.53. Conclusions: The greatest risk factor for Hepatitis B infection in β-thalassemia major patients is concluded to be multiple blood transfusions. It was also found that a huge population of Thalassemia patients was not immunized against HBV despite the severe risk. Therefore, health education and awareness campaigns are needed for the significance of Hepatitis B immunization and transfusion of screened blood.


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How to Cite

Naz, R. . ., Ullah, F. ., Muhammad, T. ., Khan, O. ., Shah, F. ., Rehman, A. u ., & Basir, N. U. . (2023). Incidence of Hepatitis B Due to Multiple Transfusions in Patients of β-Thalassemia Major: Incidence of Hepatitis B in Patients of β-Thalassemia Major. Pakistan Journal of Health Sciences, 4(02), 86–90.



Original Article