Evaluation Of Pulmonary Tuberculosis Using High Resolution Computed Tomography (HRCT): A Cross Sectional Study

Pulmonary Tuberculosis Using High Resolution

Authors

  • Amina Tasawar University Institute of Radiological and Medical Imaging Sciences, University of Lahore, Gujrat Campus
  • Akash John University Institute of Radiological and Medical Imaging Sciences, University of Lahore, Gujrat Campus
  • Abid Ali Department of Allied Health Sciences, University of Lahore, Gujrat Campus
  • Khadija Bakhtawar University Institute of Radiological and Medical Imaging Sciences, University of Lahore, Gujrat Campus
  • Mah Noor University Institute of Radiological and Medical Imaging Sciences, University of Lahore, Gujrat Campus

DOI:

https://doi.org/10.54393/pjhs.v3i01.50

Keywords:

HRCT, Tuberculosis, Pulmonary, Consolidations

Abstract

Mycobacterium is an airborne organism that spreads from person to person. Tuberculosis can affect any area of the body, although the lungs are the most commonly affected known as pulmonary tuberculosis. Objective: To evaluate pulmonary tuberculosis using High Resolution Computed Tomography. Methods: It was a cross-sectional study conducted at the private sector hospital Gujrat, Pakistan. This study was conducted over 4 months from December 2021 to March 2022.  The sample size of 91 patients was calculated via a convenient sampling approach from previously published articles. Patients who were diagnosed with TB during CT scan investigation presented at the study area were included after informed consent. A specially crafted data collection sheet was developed to contain the patient demographic statics. Results: The upper age limit occurrence of 36(39.6%) was observed in people aged 21 to 30 years, and the lowest occurrence of 7(7.7%) was observed in those aged under 21 years. Males composed 53% of the population, while females constituted 38%. (41.8 percent). The highest proportion of cough was 43 (47.3 percent), and the lowest frequency of weight loss was 14 (15.4 percent). The nodule incidence is 30(33%) and the LAP incidence is 6 (6.6 percent). Conclusion: Pulmonary tuberculosis was more prevalent among younger male individuals. The primary characterization among pulmonary tuberculosis patients was nodules, cavity, consolidation, and tree in bud shown on HRCT.

References

Sulis G, Roggi A, Matteelli A, Raviglione MC. Tuberculosis: epidemiology and control. Mediterranean journal of hematology and infectious diseases. 2014 Nov; 6(1):e2014070. doi: 10.4084/MJHID.2014.070.

Oppong JR, Mayer J, Oren E. The global health threat of African urban slums: the example of urban tuberculosis. African Geographical Review. 2015 May; 34(2):182-95. doi.org/10.1080/19376812.2014.910815

Glaziou P, Falzon D, Floyd K, Raviglione M. Global epidemiology of tuberculosis. InSeminars in respiratory and critical care medicine 2013 Feb; 34(01):003-016. Thieme Medical Publishers.

Via LE, Weiner DM, Schimel D, Lin PL, Dayao E, Tankersley SL, et al. Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus). Infection and immunity. 2013 Aug; 81(8):2909-19. doi: 10.1128/IAI.00632-13.

Reddington K, O'Grady J, Dorai-Raj S, Maher M, van Soolingen D, Barry T. Novel multiplex real-time PCR diagnostic assay for identification and differentiation of Mycobacterium tuberculosis, Mycobacterium canettii, and Mycobacterium tuberculosis complex strains. Journal of clinical microbiology. 2011 Feb; 49(2):651-7. doi: 10.1128/JCM.01426-10.

Cambier C, Falkow S, Ramakrishnan L. Host evasion and exploitation schemes of Mycobacterium tuberculosis. Cell. 2014 Dec; 159(7):1497-509. doi: 10.1016/j.cell.2014.11.024.

Nachiappan AC, Rahbar K, Shi X, Guy ES, Mortani Barbosa Jr EJ, Shroff GS, et al. Pulmonary tuberculosis: role of radiology in diagnosis and management. Radiographics. 2017 Feb; 37(1):52-72. doi: 10.1148/rg.2017160032.

Hunter RL. Tuberculosis as a three-act play: A new paradigm for the pathogenesis of pulmonary tuberculosis. Tuberculosis. 2016 Mar; 97:8-17. doi: 10.1016/j.tube.2015.11.010.

Khusro A, Aarti C. Extrapulmonary tuberculosis: An overview on infection beyond Lungs. World News of Natural Sciences. 2020;28.

Behr MA, Kaufmann E, Duffin J, Edelstein PH, Ramakrishnan L. Latent tuberculosis: two centuries of confusion. American Journal of Respiratory and Critical Care Medicine. Med. 2021 Jul; 204(2):142-148. doi: 10.1164/rccm.202011-4239PP.

Cohen A, Mathiasen VD, Schön T, Wejse C. The global prevalence of latent tuberculosis: a systematic review and meta-analysis. European Respiratory Journal. 2019 Sep; 54(3):1900655. doi: 10.1183/13993003.00655-2019.

O'Garra A, Redford PS, McNab FW, Bloom CI, Wilkinson RJ, Berry MP. The immune response in tuberculosis. Annual review of immunology. 2013; 31:475-527. doi: 10.1146/annurev-immunol-032712-095939.

Orme IM. A new unifying theory of the pathogenesis of tuberculosis. Tuberculosis. 2014 Jan; 94(1):8-14. doi: 10.1016/j.tube.2013.07.004.

Getahun H, Matteelli A, Chaisson RE, Raviglione M. Latent Mycobacterium tuberculosis infection. New England Journal of Medicine. 2015 May; 372(22):2127-35. doi: 10.1056/NEJMra1405427.

Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, et al. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nature genetics. 2011 May; 43(5):482-6. doi: 10.1038/ng.811.

van’t Hoog AH, Meme HK, Laserson KF, Agaya JA, Muchiri BG, Githui WA, et al. Screening strategies for tuberculosis prevalence surveys: the value of chest radiography and symptoms. PloS one. 2012; 7(7):e38691. doi: 10.1371/journal.pone.0038691.

Lee C-H, Lee M-C, Lin H-H, Shu C-C, Wang J-Y, Lee L-N, et al. Pulmonary tuberculosis and delay in anti-tuberculous treatment are important risk factors for chronic obstructive pulmonary disease. PloS one. 2012; 7(5):e37978. doi: 10.1371/journal.pone.0037978.

Bhalla AS, Goyal A, Guleria R, Gupta AK. Chest tuberculosis: Radiological review and imaging recommendations. Indian Journal of Radiology and Imaging. 2015 Sep; 25(3):213-25. doi: 10.4103/0971-3026.161431.

19. Bloom CI, Graham CM, Berry MP, Wilkinson KA, Oni T, Rozakeas F, et al. Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy. PLoS One. 2012;7(10):e46191. doi: 10.1371/journal.pone.0046191.

Sethi S, Dhaliwal L, Dey P, Kaur H, Yadav R. Loop-mediated isothermal amplification assay for detection of Mycobacterium tuberculosis complex in infertile women. Indian Journal of Medical Microbiology. 2016 Sep; 34(3):322-7. doi: 10.4103/0255-0857.188323.

Molica M, Mazzone C, Cordone I, Pasquale A, Niscola P, de Fabritiis P. SARS‐CoV‐2 infection anxieties and general population restrictions delay diagnosis and treatment of acute haematological malignancies. British Journal of Haematology. 2020 Jul; 190(1):e5-e8. doi: 10.1111/bjh.16785.

Skoura E, Zumla A, Bomanji J. Imaging in tuberculosis. International Journal of Infectious Diseases. 2015 Mar; 32:87-93. doi: 10.1016/j.ijid.2014.12.007.

Ahmed EEAMN. Characterization of Pulmonary Tuberculosis by Using High Resolution Computed Tomography: Sudan University of Science and Technology; 2019.

Ryu YJ. Diagnosis of pulmonary tuberculosis: recent advances and diagnostic algorithms. Tuberculosis and respiratory diseases. 2015 Apr; 78(2):64-71. doi: 10.4046/trd.2015.78.2.64.

MUSTAFA AMK. Characterization of Tuberculosis Patients Abdomen by Using Ultrasound: Sudan University of Science and Technology; 2015.

Nakanishi M, Demura Y, Ameshima S, Kosaka N, Chiba Y, Nishikawa S, et al. Utility of high-resolution computed tomography for predicting risk of sputum smear-negative pulmonary tuberculosis. European journal of radiology. 2010 Mar; 73(3):545-50. doi: 10.1016/j.ejrad.2008.12.009.

Rasheed W, Qureshi R, Jabeen N, Shah HA, Khan RN. Diagnostic Accuracy of High-Resolution Computed Tomography of Chest in Diagnosing Sputum Smear Positive and Sputum Smear Negative Pulmonary Tuberculosis. Cureus. 2020 Jun; 12(6):e8467. doi: 10.7759/cureus.8467.

Raj S, Mini MV, Abhilash Babu TG. Role of high resolution computed tomography in the evaluation of active pulmonary tuberculosis. 2017; 5(1): 20819-23. doi.org/10.18535/jmscr/v5i4.175

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Published

2022-06-30
CITATION
DOI: 10.54393/pjhs.v3i01.50
Published: 2022-06-30

How to Cite

Tasawar, A. ., John, A. ., Ali, A. ., Bakhtawar, K. ., & Noor , M. . (2022). Evaluation Of Pulmonary Tuberculosis Using High Resolution Computed Tomography (HRCT): A Cross Sectional Study: Pulmonary Tuberculosis Using High Resolution. Pakistan Journal of Health Sciences, 3(01), 42–45. https://doi.org/10.54393/pjhs.v3i01.50

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