Effect of Dexamethasone on Perioperative Lactate Levels in Donor Hepatectomy: Dexamethasone and Lactate in Donor Hepatectomy

. Rabia; Muhammad Hussan Farooq; Muhammad Ashraf; Zuhair Ali Rizvi; Muhammad Nasir Ayub Khan; Muhammad Zakria Amjad; Saad Ahmed Naveed

doi:10.54393/pjhs.v6i7.3107

Authors

. Rabia St. James's Hospital, Dublin, Ireland
Muhammad Hussan Farooq Department of Anesthesia, Shifa International Hospital, Islamabad, Pakistan
Muhammad Ashraf Department of Anesthesia, Shifa International Hospital, Islamabad, Pakistan
Zuhair Ali Rizvi Department of Anesthesia, Shifa International Hospital, Islamabad, Pakistan
Muhammad Nasir Ayub Khan Department of Anesthesia, Shifa International Hospital, Islamabad, Pakistan
Muhammad Zakria Amjad Department of Anesthesia, Shifa International Hospital, Islamabad, Pakistan
Saad Ahmed Naveed Department of Anesthesia, Shifa International Hospital, Islamabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i7.3107

Keywords:

Dexamethasone, Hyperlactatemia, Liver Donor Hepatectomy, Perioperative Lactate

Abstract

The use of intravenous dexamethasone intraoperatively has been advocated for analgesia, prevention of nausea and vomiting, post-operative sore throat and inflammation. Hyperlactinemia associated with dexamethasone is a concern in patients undergoing hepatectomy. There is limited evidence to support safety or adversity of dexamethasone in terms of hyperlactinemia. Objective: To evaluate the effect of dexamethasone administration on perioperative lactate levels in living related donors undergoing liver donor right hepatectomies. Methods: The 60 patients who had donor hepatectomy appointments in total were divided into two groups at random. After the induction of anesthesia, Group B (n=30) got dexamethasone at a dose of 8 mg while Group A (n=30) received a placebo. Perioperative lactate levels were assessed at various time points, and statistical comparisons were made between the two groups' mean lactate levels. Results: The patients' mean age was 25.68 years, and their mean BMI was 21.48 kg/m2. At every time point, Group B displayed significantly higher mean lactate levels than Group A (p=0.000). Additionally, there were statistically significant differences between the groups, an hour after drug administration, and after graft extraction (p=0.000). The perioperative mean glucose level climbed steadily in both groups. Conclusion: The administration of dexamethasone in patients undergoing right living related donor hepatectomy was associated with significantly higher perioperative lactate levels compared to patients receiving placebo.

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