Hyperglycaemia and ABO Blood Groups: An Investigative Analysis among Young Adults of Hyderabad, Sindh, Pakistan
ABO Blood Groups and Hyperglycaemia in Young Adults
DOI:
https://doi.org/10.54393/pjhs.v6i7.3050Keywords:
Hyperglycemia, ABO Blood Group, Rh Factor, Metabolic Risk, Young AdultsAbstract
Serious health problems include nerve damage, renal failure, and an increased risk of cardiovascular disease can result from chronic hyperglycemia. Objective: To investigate the relationship between hyperglycemia and ABO blood types in young adults from Hyderabad, Sindh. Methods: 582 randomly selected healthy individuals, 281 females and 301 males, aged 18 to 40, were recruited from various institutions for this cross-sectional study, which took place between January 2, 2021, and January 31, 2022. The data was gathered using the basic random approach. All participants gave their informed consent prior to recruitment. Descriptive statistics including mean, standard deviation, and frequency distributions were computed using the Chi-square test. Data collection was analyzed using SPSS version 20.0. Results: This study included 582 participants. In male individuals, the mean age was 27.83 ± 5.478, and in females, 22.27 ± 4.730. The mean BMI was 25.81 ± 5.08 in males and 24.00 ±4.90 in females. The 207 B blood group individuals were found to be obese, comprising 112 males and 95 females, followed by 195 individuals with blood group O, 128 individuals with blood group A, and 52 individuals with blood group AB. People who are Rh-positive and have blood group B were shown to be more likely to experience elevated hyperglycemia. Conclusion: Blood group B and Rh-positive status may be linked to higher hyperglycemia risk in young adults from Hyderabad, suggesting blood typing as a potential screening tool.
References
Mohamed SM, Shalaby MA, El-Shiekh RA, El-Banna HA, Emam SR, Bakr AF. Metabolic syndrome: risk factors, diagnosis, pathogenesis, and management with natural approaches. Food Chemistry Advances. 2023 Dec; 3: 100335. doi: 10.1016/j.focha.2023.100335.
Ingrosso DM, Primavera M, Samvelyan S, Tagi VM, Chiarelli F. Stress and diabetes mellitus: pathogenetic mechanisms and clinical outcome. Hormone Research in Paediatrics. 2023 Mar; 96(1): 34-43. doi: 10.1159/000522431.
Pasquel FJ, Lansang MC, Dhatariya K, Umpierrez GE. Management of Diabetes and Hyperglycaemia in the Hospital. The Lancet Diabetes & Endocrinology. 2021 Mar; 9(3): 174-88. doi: 10.1016/S2213-8587(20)30381-8.
Mifsud S, Schembri EL, Gruppetta M. Stress-Induced Hyperglycaemia. British Journal of Hospital Medicine. 2018 Nov; 79(11): 634-9. doi: 10.12968/hmed.2018.79.11.634.
Hossain MJ, Al‐Mamun M, Islam MR. Diabetes mellitus, the fastest growing global public health concern: Early detection should be focused. Health Science Reports. 2024 Mar; 7(3): e2004. doi: 10.1002/hsr2.2004.
Alp H, Sahin A, Karabaglı P, Karaburgu S, Yılmaz Sanal B, Yuksel EB. Current perspective on diabetes mellitus in clinical sciences.
Li HY and Guo K. Blood group testing. Frontiers in Medicine. 2022 Feb; 9: 827619. doi: 10.3389/fmed.2022.827619.
Abegaz SB. Human ABO blood groups and their associations with different diseases. BioMed Research International. 2021 Jan; 2021(1): 6629060. doi: 10.1155/2021/6629060.
Fathallah N, Slim R, Larif S, Hmouda H, Ben Salem C. Drug-Induced Hyperglycaemia and Diabetes. Drug Safety. 2015 Dec; 38(12): 1153-68. doi: 10.1007/s40264-015-0339-z.
Getawa S, Bayleyegn B, Aynalem M, Worku YB, Adane T. Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis. Journal of International Medical Research. 2022 Oct; 50(10): 03000605221129547. doi: 10.1177/03000605221129547.
Anyiam AF, Obeagu EI, Obi E, Omosigho PO, Irondi EA, Arinze-Anyiam OC et al. ABO blood groups and gestational diabetes among pregnant women attending University of Ilorin Teaching Hospital, Kwara State, Nigeria. International Journal of Research and Reports in Hematology. 2022 Jun; 5(2): 113-21.
Gata AM, Kasim SF, Mohammed SM, Samanje J. Relationship of blood groups to the incidence of hyperuricemia and hyperglycemia. Journal of Techniques. 2021 Dec; 3(4): 32-6. doi: 10.51173/jt.v3i4.383.
Ghafar M, Khwaja S, Zahid M, Hussain SI, Karim A, Akram A. Association of blood groups/Rh and diabetes mellitus in Karachi city, Pakistan. Brazilian Journal of Biology. 2022 Jan; 84: e252952. doi: 10.1590/1519-6984.252952.
Vaara S. Clinical and genetic risk factors in acute coronary syndromes. Unigrafia; 2017 Jan.
Shaikh SA, Laghari ZA, Memon SF, Warsi J. Distribution of ABO and Rhesus Blood Group in Healthy Population of District Hyderabad, Sindh. Journal of Liaquat University of Medical & Health Sciences. 2020 Oct; 19(03): 215-8.
Yamamoto F. Molecular genetics and genomics of the ABO blood group system. Annals of Blood. 2021 Sep;6. doi: 10.21037/aob-20-71.
Shams S, Khan S, Ajmal H, Siraj F, Afridi SG. Association of ABO Blood Groups with Diabetes Mellitus among the University Students of District Mardan, Pakistan. International Journal of Hematology and Blood Disorders. 2017; 2(2): 1-3. doi: 10.15226/2639-7986/2/2/00111.
Pandey DJ. Association between the ABO-RH blood groups and type-2 diabetes mellitus. Published online. 2019.
Anwar R, Siddiqui IA, Ahmed F, Mustafa N, Askari S, Fawwad A. Possible linkage between ABO blood groups and type 2 diabetes; an observational study from Karachi, Pakistan. Pakistan Journal of Medical Research. 2019 Mar; 58(1): 17.
Kamil M, Al-Jamal HA, Yusoff NM. Association of ABO blood groups with diabetes mellitus. Libyan Journal of Medicine. 2010 Feb; 5(1). doi: 10.3402/ljm.v5i0.4847.
Hegde B. The distribution of the ABO and Rh (D) blood types in patients with type II diabetes mellitus. International Journal of Advanced Research. 2015 Nov; 3(11): 1561-5.
Ewald DR and Sumner SC. Human microbiota, blood group antigens, and disease. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2018 May; 10(3): e1413. doi: 10.1002/wsbm.1413.
Günaydın ZY and Yılmaz E. The association between ABO blood groups and TASC II classification in patients with peripheral artery disease. Vascular. 2023 Jun; 31(3): 467-72. doi: 10.1177/17085381211068736.
Zarkasi KA, Abdullah N, Abdul Murad NA, Ahmad N, Jamal R. Genetic Factors for Coronary Heart sDisease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies. Diagnostics. 2022 Oct; 12(10): 2561. doi: 10.3390/diagnostics12102561.
Veturi Y, Lucas A, Bradford Y, Hui D, Dudek S, Theusch E et al. A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts. Nature Genetics. 2021 Jul; 53(7): 972-81. doi: 10.1038/s41588-021-00879-y.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Pakistan Journal of Health Sciences

This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments