Comparative Analysis of Serum Uric Acid Levels and Bone Mineral Density Among Elderly Individuals : Serum Uric Acid and BMD among Elderly Individuals

Nizam Ahmed; Siraj Ahmed Butt; Imran Khan Maher; Muhammad Faraz Jokhio; Rasheed Ahmed Bhatti; Sheeba Faryal

doi:10.54393/pjhs.v6i3.2936

Authors

Nizam Ahmed Department of Orthopedics Surgery and Traumatology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Siraj Ahmed Butt Department of Orthopedics Surgery and Traumatology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Imran Khan Maher Department of Orthopedics Surgery and Traumatology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Muhammad Faraz Jokhio Department of Orthopedics Surgery and Traumatology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Rasheed Ahmed Bhatti Department of Orthopedics Surgery, Bilawal Medical College for Boys, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Sheeba Faryal Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i3.2936

Keywords:

Uric Acid, Bone Mineral Density, Osteoporosis, Dual-Energy X-Ray Absorptiometry

Abstract

Osteoporosis is a major public health concern, particularly in aging populations. Emerging evidence suggests that serum uric acid (SUA) may influence bone mineral density (BMD) due to its antioxidant properties. However, the relationship between SUA levels and BMD remains controversial. Objectives: To compare BMD among individuals with low and high SUA levels and to determine the association between SUA and osteoporosis prevalence. Methods: This cross-sectional-comparative study was done at Liaquat University Hospital, Hyderabad, from March 2022 to August 2022. A total of 182 participants (≥50 years old) who underwent DEXA scan for BMD assessment were included using a purposive sampling technique. Participants were categorized into low SUA (<5.5 mg/dL) and high SUA (>5.5 mg/dL) groups. BMD at the lumbar spine, total hip, and femoral neck was recorded. Statistical analysis was performed using SPSS v.24, with t-tests, chi-square tests, and Pearson’s correlation applied. A p-value of <0.05 was considered significant. Results: Participants with high SUA levels had significantly higher BMI (p=0.01). Lumbar spine BMD was significantly lower in the high SUA group (p=0.04), but no significant differences were observed for total hip and femoral neck BMD. Pearson’s correlation showed a positive association between SUA and lumbar BMD (r=0.32, p=0.015). Conclusions: It was concluded that higher SUA levels were associated with lower osteoporosis prevalence but paradoxically lower lumbar BMD.

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