Frequency of Depressive Symptoms in Women with Polycystic Ovary Syndrome and Obesity versus Women with Polycystic Ovary Syndrome without Obesity : Depressive Symptoms in PCOS and Obesity

Sheeba Faryal; Ayesha Nighat; Adnan Ahmed; Saba Bashir; Farah Liaquat; Hanozia Shah

doi:10.54393/pjhs.v5i04.1414

Authors

Sheeba Faryal Department of Medicine, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Pakistan
Ayesha Nighat Department of Psychiatry and Behavioral Sciences, Liaquat University of Medical and Health Sciences, Jamshoro (LUMHS), Pakistan
Adnan Ahmed Department of Diagnostic Radiology, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Pakistan
Saba Bashir The University of Modern Sciences, Indus Medical College, Tando Muhammad Khan, Pakistan
Farah Liaquat Baqai Medical University, Karachi, Pakistan
Hanozia Shah Bilawal Medical College, Liaquat University of Medical and Health Scicnces (LUMHS), Jamshoro, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i04.1414

Keywords:

Polycystic Ovary Syndrome, Depressive Symptoms, Obesity, Women's Health

Abstract

Polycystic Ovary Syndrome (PCOS) is a complicated hormonal condition that impacts women globally. Its association with obesity and its potential impact on mental health, specifically depressive symptoms, has gained increasing attention. This study aimed to determine the relationship between depressive symptoms and PCOS in women, with a focus on the influence of obesity. Objective: To compare the frequency of depressive symptoms among women who have PCOS, categorized based on whether they are obese or not. Methods: A cross sectional descriptive study was conducted on electronic medical records of 194 women with PCOS from a tertiary care hospital. Data included demographic information, clinical characteristics of PCOS, and depressive symptom scores measured using the Center for Epidemiologic Studies-Depression (CES-D) scale. The study was conducted from Apr 2021 to Oct 2021 for a period of 6 months. Results: Women with PCOS and obesity exhibited significantly higher mean CES-D scores and a higher prevalence of clinically significant depressive symptoms (CES-D ≥ 16) compared to those without obesity. Hyperandrogenism, oligomenorrhea, and hirsutism were more prevalent in women with PCOS and obesity. Conclusions: The study found out that women with PCOS and obesity appear to be at a higher risk of experiencing clinically significant depressive symptoms. Healthcare providers should consider the mental health needs of this population, emphasizing a multidisciplinary approach to care.

References

Butt MS, Saleem J, Zakar R, Aiman S, Bukhari GM, Fischer F et al. Comparison of physical activity levels and dietary habits between women with polycystic ovarian syndrome and healthy controls of reproductive age: a case-control study. BMC Women's Health. 2024 Jan; 24(1): 29. doi: 10.1186/s12905-023-02866-3. DOI: https://doi.org/10.1186/s12905-023-02866-3

Tanveer M, Hohmann A, Roy N, Zeba A, Tanveer U, Siener M et al. The current prevalence of underweight, overweight, and obesity associated with demographic factors among Pakistan school-aged children and adolescents-An empirical cross-sectional study. International Journal of Environmental Research and Public Health. 2022 Sep; 19(18): 11619. doi: 10.3390/ijerph191811619. DOI: https://doi.org/10.3390/ijerph191811619

Kolhe JV, Chhipa AS, Butani S, Chavda V, Patel SS. PCOS and depression: common links and potential targets. Reproductive Sciences. 2021 Oct; (2022) 29: 3106–23. doi: 10.1007/s43032-021-00765-2. DOI: https://doi.org/10.1007/s43032-021-00765-2

Khan AY, Abdullah MA, Gul R, Bhutta HR, Imran M, Mazhar SB et al. Prevalence of Anxiety and Depression Among Women With Polycystic Ovarian Syndrome: A Cross-Sectional Study From a Tertiary Care Hospital of Islamabad, Pakistan. Cureus. 2024 Jan; 16(1): 1-10. doi: 10.7759/cureus.52540. DOI: https://doi.org/10.7759/cureus.52540

Greenwood EA, Yaffe K, Wellons MF, Cedars MI, Huddleston HG. Depression over the lifespan in a population-based cohort of women with polycystic ovary syndrome: longitudinal analysis. The Journal of Clinical Endocrinology and Metabolism. 2019 Jul; 104(7): 2809-19. doi: 10.1210/jc.2019-00234. DOI: https://doi.org/10.1210/jc.2019-00234

Anagnostis P, Tarlatzis BC, Kauffman RP. Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences. Metabolism. 2018 Sep; 86: 33-43. doi: 10.1016/j.metabol.2017.09.016. DOI: https://doi.org/10.1016/j.metabol.2017.09.016

Anjum A, Hossain S, Sikder T, Uddin ME, Rahim DA. Investigating the prevalence of and factors associated with depressive symptoms among urban and semi-urban school adolescents in Bangladesh: a pilot study. International Health. 2022 Jul; 14(4): 354-62. doi: 10.1093/inthealth/ihz092. DOI: https://doi.org/10.1093/inthealth/ihz092

Sam S. Obesity and polycystic ovary syndrome. Obesity Management. 2007 Apr; 3(2): 69-73. doi: 10.1089/obe.2007.0019. DOI: https://doi.org/10.1089/obe.2007.0019

Hamman RF, Bell RA, Dabelea D, D'Agostino RB Jr, Dolan L, Imperatore G et al., SEARCH for Diabetes in Youth Study Group. The SEARCH for Diabetes in Youth study: rationale, findings, and future directions. Diabetes Care. 2014 Dec; 37(12): 3336-44. doi: 10.2337/dc14-0574. DOI: https://doi.org/10.2337/dc14-0574

Hood KK, Beavers DP, Yi-Frazier J, Bell R, Dabelea D, Mckeown RE et al. Psychosocial burden and glycemic control during the first 6 years of diabetes: results from the SEARCH for Diabetes in Youth study. Journal of Adolescent Health. 2014 Oct; 55(4): 498-504. doi: 10.1016/j.jadohealth.2014.03.011. DOI: https://doi.org/10.1016/j.jadohealth.2014.03.011

Copeland KC, Zeitler P, Geffner M, Guandalini C, Higgins J, Hirst K et al. Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. The Journal of Clinical Endocrinology and Metabolism. 2011 Jan; 96(1): 159-67. doi: 10.1210/jc.2010-1642. DOI: https://doi.org/10.1210/jc.2010-1642

Quek YH, Tam WW, Zhang MW, Ho RC. Exploring the association between childhood and adolescent obesity and depression: a meta‐analysis. Obesity Reviews. 2017 Jul; 18(7): 742-54. doi: 10.1111/obr.12535. DOI: https://doi.org/10.1111/obr.12535

Escobar-Morreale HF, Botella-Carretero JI, Alvarez-Blasco F, Sancho J, San Millán JL. The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery. The Journal of Clinical Endocrinology and Metabolism. 2005 Dec; 90(12): 6364-9. doi: 10.1210/jc.2005-1490. DOI: https://doi.org/10.1210/jc.2005-1490

Hopkins CS, Kimble LP, Hodges HF, Koci AF, Mills BB. A mixed-methods study of coping and depression in adolescent girls with polycystic ovary syndrome. Journal of the American Association of Nurse Practitioners. 2019 Mar; 31(3): 189-97. doi: 10.1097/JXX.0000000000000125. DOI: https://doi.org/10.1097/JXX.0000000000000125

Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ et al. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews. March 2019. doi: 10.1002/14651858.CD007506.pub4. DOI: https://doi.org/10.1002/14651858.CD007506.pub4

Chaudhuri A. Polycystic ovary syndrome: Causes, symptoms, pathophysiology, and remedies. Obesity Medicine. 2023 May; 39: 100480. doi: 10.1016/j.obmed.2023.100480. DOI: https://doi.org/10.1016/j.obmed.2023.100480

Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, Lizneva D, Natterson-Horowtiz B, Teede HJ, Yildiz BO. Polycystic ovary syndrome. Nature reviews Disease primers. 2016 Aug; 2(1): 1-8. doi: 10.1038/nrdp.2016.57. DOI: https://doi.org/10.1038/nrdp.2016.57

Deeks AA, Gibson-Helm ME, Teede HJ. Anxiety and depression in polycystic ovary syndrome: a comprehensive investigation. Fertility and Sterility. 2010 May; 93(7): 2421-3. doi: 10.1016/j.fertnstert.2009.09.018. DOI: https://doi.org/10.1016/j.fertnstert.2009.09.018

O'Reilly MW, Taylor AE, Crabtree NJ, Hughes BA, Capper F, Crowley RK et al. Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione. The Journal of Clinical Endocrinology and Metabolism. 2014 Mar; 99(3): 1027-36. doi: 10.1210/jc.2013-3399. DOI: https://doi.org/10.1210/jc.2013-3399

Cooney LG and Dokras A. Depression and anxiety in polycystic ovary syndrome: etiology and treatment. Current Psychiatry Reports. 2017 Nov; 19: 1-0. doi: 10.1007/s11920-017-0834-2. DOI: https://doi.org/10.1007/s11920-017-0834-2

Dokras A, Clifton S, Futterweit W, Wild R. Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis. Fertility and Sterility. 2012 Jan; 97(1): 225-30. doi: 10.1016/j.fertnstert.2011.10.022. DOI: https://doi.org/10.1016/j.fertnstert.2011.10.022

Barry JA, Kuczmierczyk AR, Hardiman PJ. Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis. Human reproduction. 2011 Sep; 26(9): 2442-51. doi: 10.1093/humrep/der197. DOI: https://doi.org/10.1093/humrep/der197