Impact of Pharmacist-Led Interventions On Medication Adherence in Patients with Chronic Psychiatric Disorders
Pharmacist On Medication Adherence in Patients with Chronic Psychiatric Disorders
DOI:
https://doi.org/10.54393/pjhs.v6i4.2923Keywords:
Medication Adherence, Psychiatric Patients, Pharmacist Interventions, Mixed-MethodsAbstract
Mental health disorders represent a growing global health challenge, affecting an estimated 970 million people worldwide as of 2019. These disorders not only impair individuals' ability to function but also impose significant economic and social burdens. In a country like Pakistan, mental health treatment resources are minimal, and chronic psychiatric disorders like bipolar personality disorder, schizophrenia, and chronic depression have become an enormous burden. Objectives: To assess the impact of pharmacist-led interventions on medication adherence among psychiatric patients in Rawalpindi, Pakistan. Methods: This quasi-experimental mixed-method study employed a pre-post intervention design. Conducted in two psychiatric clinics in Rawalpindi, it involved a total sample of 60 participants for the quantitative phase and 10 for the qualitative phase. Quantitative data were analyzed using McNamara’s test and the Wilcoxon signed-rank test, while qualitative data underwent thematic analysis. Results: Significant improvements in medication adherence were observed post-intervention, as evidenced by Paired Chi-Square (McNamara’s test) and Wilcoxon Signed Rank Test. Thematic analysis of the qualitative data identified four main themes with three sub-themes, providing insights into the patients’ attitudes, knowledge, and practices regarding medication adherence. Conclusions: It was concluded that pharmacist-led interventions were found to be effective in enhancing medication adherence among psychiatric patients. The study underscores the importance of ongoing support and education for this patient group and recommends the continuation of such interventions to sustain improvements in adherence.
References
Karekla M, Kasinopoulos O, Neto DD, Ebert DD, Van Daele T, Nordgreen T et al. Best Practices and Recommendations for Digital Interventions to Improve Engagement and Adherence in Chronic Illness Sufferers. European Psychologist. 2019 Feb. doi: 10.1027/1016-9040/a000349.
Eaves S, Gonzalvo J, Hamm JA, Williams G, Ott C. The Evolving Role of the Pharmacist for Individuals with Serious Mental Illness. Journal of the American Pharmacists Association. 2020 Sep; 60(5): S11-4. doi: 10.1016/j.japh.2020.04.017.
Sabaté E and Editor. Adherence to Long-Term Therapies: Evidence for Action. World Health Organization. 2003.
Otieno PA, Campbell S, Maley S, Obinju Arunga T, Otieno Okumu M. A Systematic Review of Pharmacist‐Led Antimicrobial Stewardship Programs in Sub‐Saharan Africa. International Journal of Clinical Practice. 2022; 2022(1): 3639943. doi: 10.1155/2022/3639943.
Sharma JJ, McMillan SS, Samaranayake NR, Waas DA, Coombes ID, Wheeler AJ. Multifaceted Pharmacist-Led Interventions in Secondary Care Settings Between Countries of Various Income Levels: A Scoping Review Protocol. British Medical Journal Open. 2024 Apr; 14(4): e083726. doi: 10.1136/bmjopen-2023-083726.
Costa E, Giardini A, Savin M, Menditto E, Lehane E, Laosa O et al. Interventional tools to improve medication adherence: review of literature. Patient preference and adherence. 2015 Sep 14:1303-14. doi: 10.2147/PPA.S87551.
Cahaya N, Kristina SA, Widayanti AW, Green J. Interventions to Improve Medication Adherence in People with Schizophrenia: A Systematic Review. Patient Preference and Adherence. 2022 Jan: 2431-49. doi: 10.2147/PPA.S378951.
Elnaem MH, Rosley NF, Alhifany AA, Elrggal ME, Cheema E. Impact of Pharmacist-Led Interventions On Medication Adherence and Clinical Outcomes in Patients with Hypertension and Hyperlipidemia: A Scoping Review of Published Literature. Journal of Multidisciplinary Healthcare. 2020 Jul: 635-45. doi: 10.2147/JMDH.S257273.
Syrnyk M and Glass B. Pharmacist Interventions in Medication Adherence in Patients with Mental Health Disorders: A Scoping Review. International Journal of Pharmacy Practice. 2023 Oct; 31(5): 449-58. doi: 10.1093/ijpp/riad037.
Ng R, El-Den S, Stewart V, Collins JC, Roennfeldt H, McMillan SS et al. Pharmacist-led Interventions for People Living with Severe and Persistent Mental Illness: A Systematic Review. Australian and New Zealand Journal of Psychiatry. 2022 Sep; 56(9): 1080-103. doi: 10.1177/00048674211048410.
Lee D, Hevia LC, Mesdaq H, Gharibyar N. Pharmacist-Led Care: Improving Treatment Outcomes in Neuropsychiatric Disorders. Pharmacology and Pharmacy. 2024 Dec; 15(12): 538-51. doi: 10.4236/pp.2024.1512030.
Davis B, Qian J, Ngorsuraches S, Jeminiwa R, Garza KB. The Clinical Impact of Pharmacist Services On Mental Health Collaborative Teams: A Systematic Review. Journal of the American Pharmacists Association. 2020 Sep; 60(5): S44-53. doi: 10.1016/j.japh.2020.05.006.
Mohiuddin AK. Psychiatric Pharmacy: New Role of Pharmacists in Mental Health. Journal of Psychiatry Mental Disorders. 2019; 4(1): 1010. doi: 10.32474/SJPBS.2019.02.000144.
Wang X, Wang S, Yu X, Ma Z, Wang H, Yang J et al. Impact of Pharmacist‐Led Medication Therapy Management in Ambulatory Elderly Patients with Chronic Diseases. British Journal of Clinical Pharmacology. 2021 Jul; 87(7): 2937-44. doi: 10.1111/bcp.14709.
Umeh AU, Chima UE, Agbo CE, Chiekwe OS, Eze AE, Nwachuya CA et al. Pharmacist-Led Medication Therapy Management: Impact On Healthcare Utilization and Costs. American Journal of Pharmacotherapy and Pharmaceutical Sciences. 2025 Feb; 4. doi: 10.25259/AJPPS_2025_004.
Villasante-Tezanos AG and De-Leon JO. Adherence to Psychiatric Medications: Comparing Patients with Schizophrenia, Bipolar Disorder and Major Depression. Neuro-Psycho-Pharmacol Hung. 2021; 23(4): 363-73.
Gorgzadeh N, Mohebbi N, Gholami K, Amini H, Nejatisafa AA, Salamzadeh J. Impact of Clinical Pharmacist-led Interventions on the Outcomes of Patients with Bipolar I Disorder: A Randomized Clinical Trial. Journal of Research in Pharmacy Practice. 2024 Jul; 13(3): 78-84. doi: 10.4103/jrpp.jrpp_52_24.
Papus M, Dima AL, Viprey M, Schott AM, Schneider MP, Novais T. Motivational Interviewing to Support Medication Adherence in Adults with Chronic Conditions: Systematic Review of Randomized Controlled Trials. Patient Education and Counseling. 2022 Nov; 105(11): 3186-203. doi: 10.1016/j.pec.2022.06.013.
Aubeeluck E, Al‐Arkee S, Finlay K, Jalal Z. The Impact of Pharmacy Care and Motivational Interviewing On Improving Medication Adherence in Patients with Cardiovascular Diseases: A Systematic Review of Randomized Controlled Trials. International Journal of Clinical Practice. 2021 Nov; 75(11): e14457. doi: 10.1111/ijcp.14457.
Wang L, Zhao Y, Han L, Zhang H, Chen H, Liu A et al. Pharmacist-Led Management Model and Medication Adherence Among Patients with Chronic Heart Failure: A Randomized Clinical Trial. Journal of the American Medical Association Network Open. 2024 Dec; 7(12): e2453976-. doi: 10.1001/jamanetworkopen.2024.53976.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Pakistan Journal of Health Sciences

This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments