Endometrial Hyperplasia on Rising Trends among Peri-Menopausal Women: Endometrial Hyperplasia among Peri-Menopausal Women

Shagufta Tabassum; Amna Aziz; Faiza Suman

doi:10.54393/pjhs.v6i1.2498

Authors

Shagufta Tabassum Department of Obstetrics and Gynaecology, Nishtar Medical University, Multan, Pakistan
Amna Aziz Department of Obstetrics and Gynaecology, Nishtar Medical University, Multan, Pakistan
Faiza Suman Department of Obstetrics and Gynaecology, Nishtar-II Hospital, Multan, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i1.2498

Keywords:

Abnormal Uterine Bleeding, Endometrial Hyperplasia, Perimenopause, Histopathological Findings

Abstract

Endometrial hyperplasia demonstrates a uterine pathology characterized by a range of endometrial morphological remodeling. The clinical importance of endometrial hyperplasia lies in its progression to endometrial carcinoma. Objectives: To analyze histopathological findings of endometrial biopsy in perimenopausal women having abnormal uterine bleeding and to observe the correlation of various risk factors with endometrial hyperplasia. Methods: The cross-sectional study was conducted at the Department of Gynaecology, Nishtar Medical University, Pakistan. Two hundred and fifty-five perimenopausal women having abnormal uterine bleeding of 3-12 months’ duration were included. The participants were subjected to histopathological analysis of endometrial biopsy obtained by dilatation and curettage. All the information and the histopathology report were entered on a specific proforma. Data analysis was performed using SPSS software version 26.0. Results: Out of a total of 255 patients, the mean age was 48+/-6 years. A vast majority was grand multiparous (n=163, 64%). Out of a total of 255 endometrial samples, the majority (n=88, 34.5%) turned out to be proliferative endometrium, indicating hormonal imbalance like unopposed estrogen stimulation. In total, 66 (25.9%) samples fulfilled the criteria of endometrial hyperplasia. 54 (21.7%) had endometrial hyperplasia without atypia, while 12 (4.2%) had atypical endometrial hyperplasia. Regarding atypical uterine bleeding, the commonest symptom was heavy regular cycle (n=74, 29%) followed by irregular vaginal bleeding (n=70, 27.5%). Conclusions: It was concluded that atypical uterine bleeding in the peri-menopausal life period is alarming. All such women should undergo endometrial histopathological examination to detect endometrial hyperplasia to prevent its progression to endometrial carcinoma.

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