Ankle-Brachial Index as a Predictor of Peripheral Arterial Disease in Newly Diagnosed Hypertensive Patients

Peripheral Arterial Disease in Hypertensive Patients

Authors

  • Safdar Ali Pervez Department of Medicine, Khairpur Medical College, Civil Hospital, Khairpur, Pakistan
  • Munir Ahmed Channa Department of Medicine, Muhammad Medical College and Hospital, Mirpurkhas, Pakistan
  • Mahesh Kumar Department of Medicine, Muhammad Medical College and Hospital, Mirpurkhas, Pakistan
  • Abdul Hayee Phulpoto Department of Medicine, Khairpur Medical College, Civil Hospital, Khairpur, Pakistan
  • Abdul Qayoom Memon Department of Medicine, Khairpur Medical College, Civil Hospital, Khairpur, Pakistan
  • Asif Aziz Department of Medicine, Gambat Medical College, Gambat, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i11.2350

Keywords:

Hypertension, Peripheral Arterial Disease, Ankle-Brachial Index, Blood Pressure, Cardiovascular Risk

Abstract

Hypertension was a major risk factor for cardiovascular disorder including Peripheral Arterial Disease (PAD). Objective: To evaluate the risk of Peripheral Arterial Disease (PAD) in newly diagnosed hypertensive patients using Ankle-Brachial Index (ABI) measurements and to determine its potential role as a predictor of cardiovascular risks in this population. Methods: The study was an observational, cross-sectional study. This study was conducted in Khairpur Medical College Civil Hospital Khairpur Mirs. The duration of this study was six months, from November 2023 to April 2024This study include n= 246 newly diagnosed hypertension. Three levels of ABI had been identified through determining the ABI in both legs: low ABI (<0.9), normal ABI (0.9-1.4), and high ABI (>1.4).  Student’s t-test. Pearson correlation test have been utilized when assessing the significance of the association between ABI levels and blood pressure values. Results: ABI was normal in 60% of the 246 participants, low in 20% and high in 20% of them. In comparison to those who had normal and high ABI, participants who had low ABI showed considerably higher SBP in both lower limbs (p < 0.001). Furthermore, there was additionally a significant distinction (p < 0.001) in the SBP and DBP among people who had high ABI. Participants with average ABI had higher SBP in their right upper limb than those who suffered from elevated ABI (p < 0.001). Conclusion: This study showed that in individuals who have recently identified high blood pressure, there was a significant relationship among ABI levels and arterial pressure levels.

References

Li J, Somers VK, Gao X, Chen Z, Ju J, Lin Q et al. Evaluation of optimal diastolic blood pressure range among adults with treated systolic blood pressure less than 130 mm Hg. Journal of the American Medical Association Network Open. 2021 Feb; 4(2): e2037554-. doi: 10.1001/jamanetworkopen.2020.37554.

Schutte AE, Kollias A, Stergiou GS. Blood pressure and its variability: classic and novel measurement techniques. Nature Reviews Cardiology. 2022 Oct; 19(10): 643-54. doi: 10.1038/s41569-022-00690-0.

Shrivastava A, Chakkaravarthy M, Shah MA. A new machine learning method for predicting systolic and diastolic blood pressure using clinical characteristics. Healthcare Analytics. 2023 Dec; 4: 100219. doi: 10.1016/j.health.2023.100219.

Drawz PE, Beddhu S, Kramer HJ, Rakotz M, Rocco MV, Whelton PK. Blood pressure measurement: a KDOQI perspective. American Journal of Kidney Diseases. 2020 Mar; 75(3): 426-34. doi: 10.1053/j.ajkd.2019.08.030.

Golledge J. Update on the pathophysiology and medical treatment of peripheral artery disease. Nature reviews cardiology. 2022 Jul;19(7):456-74. doi: 10.1038/s41569-021-00663-9. Epub 2022 Jan 7.

Cáceres-Farfán L, Moreno-Loaiza M, Cubas WS. Ankle-brachial index: more than a diagnostic test?. Archivos Peruanos de Cardiología y Cirugía Cardiovascular. 2021 Oct; 2(4): 254. doi: 10.47487/apcyccv.v2i4.168.

Herraiz-Adillo A, Cavero-Redondo I, Alvarez-Bueno C, Pozuelo-Carrascosa DP, Solera-Martinez M. The accuracy of toe brachial index and ankle brachial index in the diagnosis of lower limb peripheral arterial disease: a systematic review and meta-analysis. Atherosclerosis. 2020 Dec; 315: 81-92. doi: 10.1016/j.atherosclerosis.2020.09.026.

Danieluk A and Chlabicz S. Automated measurements of ankle-brachial index: a narrative review. Journal of Clinical Medicine. 2021 Nov; 10(21): 5161. doi: 10.3390/jcm10215161.

Poredos P, Stanek A, Catalano M, Boc V. Ankle-Brachial Index: Diagnostic Tool of Peripheral Arterial Disease and Predictor of Cardiovascular Risk-An Update of Current Knowledge. Angiology. 2024 Jan: 00033197241226512. doi: 10.1177/00033197241226512.

Singhania P, Das TC, Bose C, Mondal A, Bhattacharjee R, Singh A et al. Toe brachial index and not ankle brachial index is appropriate in initial evaluation of peripheral arterial disease in type 2 diabetes. Diabetology & Metabolic Syndrome. 2024 Feb; 16(1): 52. doi: 10.1186/s13098-024-01309-9.

Erzinger FL, Polimanti AC, Pinto DM, Murta G, Cury MV, Silva RB, Biagioni RB, Belckzac SQ, Joviliano EE, Araujo WJ, Oliveira JC. Brazilian Society of Angiology and Vascular Surgery guidelines on peripheral artery disease. Jornal Vascular Brasileiro. 2024 Oct 28;23:e20230059. doi: 10.1590/1677-5449.202300592.

Myslinski W, Stanek A, Feldo M, Mosiewicz J. Ankle‐brachial index as the best predictor of first acute coronary syndrome in patients with treated systemic hypertension. BioMed Research International. 2020 Jul; 2020(1): 6471098. doi: 10.1155/2020/6471098.

Uchida S, Kamiya K, Hamazaki N, Nozaki K, Ichikawa T, Yamashita M et al. The Association between the Level of Ankle-Brachial Index and the Risk of Poor Physical Function in Patients with Cardiovascular Disease. Journal of Atherosclerosis and Thrombosis. 2024 Apr; 31(4): 419-28. doi: 10.5551/jat.64531.

Pereira Filho AJ, Sartipy F, Lundin F, Wahlberg E, Sigvant B. Impact of ankle brachial index calculations on peripheral arterial disease prevalence and as a predictor of cardiovascular risk. European Journal of Vascular and Endovascular Surgery. 2022 Aug; 64(2-3): 217-24. doi: 10.1016/j.ejvs.2022.05.001.

Sukhija R, Aronow WS, Yalamanchili K, Peterson SJ, Frishman WH, Babu S. Association of ankle-brachial index with severity of angiographic coronary artery disease in patients with peripheral arterial disease and coronary artery disease. Cardiology. 2005 Apr; 103(3): 158-60. doi: 10.1159/000084586.

Chang YM, Lee TL, Su HC, Chien CY, Lin TY, Lin SH et al. The Association between Ankle-Brachial Index/Pulse Wave Velocity and Cerebral Large and Small Vessel Diseases in Stroke Patients. Diagnostics. 2023 Apr; 13(8): 1455. doi: 10.3390/diagnostics13081455.

Yang W, Sun L, He Y, Xu X, Gan L, Guo T et al. Association between four-limb blood pressure differences and arterial stiffness: a cross-sectional study. Postgraduate Medicine. 2022 Apr; 134(3): 309-15. doi: 10.1080/00325481.2022.2046415.

Richard NA, Hodges L, Koehle MS. Elevated peak systolic blood pressure in endurance‐trained athletes: Physiology or pathology?. Scandinavian Journal of Medicine & Science in Sports. 2021 May; 31(5): 956-66. doi: 10.1111/sms.13914.

Laurent S and Boutouyrie P. Arterial stiffness and hypertension in the elderly. Frontiers in Cardiovascular Medicine. 2020 Oct; 7: 544302. doi: 10.3389/fcvm.2020.544302.

Hasan M, Verma MK, Gupta N, Jasrotia RB, Gangwar V, Tiwari S. risk of peripheral arterial disease (PAD) development by measuring ankle brachial index (ABI) in newly diagnosed hypertensive patients: a cross-sectional study. International Journal of Medicine & Public Health. 2024 Jul; 14(3): 268. doi: 10.70034/ijmedph.2024.3.48.

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Published

2024-11-30
CITATION
DOI: 10.54393/pjhs.v5i11.2350
Published: 2024-11-30

How to Cite

Pervez, S. A., Channa, M. A., Kumar, M., Phulpoto, A. H., Memon, A. Q., & Aziz, A. (2024). Ankle-Brachial Index as a Predictor of Peripheral Arterial Disease in Newly Diagnosed Hypertensive Patients: Peripheral Arterial Disease in Hypertensive Patients. Pakistan Journal of Health Sciences, 5(11), 144–148. https://doi.org/10.54393/pjhs.v5i11.2350

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