Relationship of Systemic Inflammatory Markers and Body Mass Index with Primary Osteoarthritis: Inflammatory Markers and Body Mass Index in Osteoarthritis

Roma Gulzar; Tafazzul E Haque Mahmud; Aflak Rasheed; Usman Hafeez; Faizan Ahmed

doi:10.54393/pjhs.v6i4.1880

Authors

Roma Gulzar Shaikh Zayed Post Medical Institute, Lahore, Pakistan
Tafazzul E Haque Mahmud Shaikh Zayed Post Medical Institute, Lahore, Pakistan
Aflak Rasheed Shaikh Zayed Post Medical Institute, Lahore, Pakistan
Usman Hafeez Shaikh Zayed Post Medical Institute, Lahore, Pakistan
Faizan Ahmed Shaikh Zayed Post Medical Institute, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i4.1880

Keywords:

Osteoarthritis, Inflammatory Markers, Body Mass Index, Radiographic Progression

Abstract

Osteoarthritis (OA) is degenerative disorder which involves synovial inflammation. Erythrocyte sedimentation rate, Body mass index and C-reactive protein are commonly used markers to determine infection or inflammation. Objective: To measure the level of raised levels of erythrocyte sedimentation rate and C-reactive protein in primary osteoarthritis and to identify the association of body mass index with osteoarthritis in Pakistani population. Methods: This descriptive cross-sectional study was conducted at Department of Rheumatology, Shaikh Zayed Hospital, Lahore, Pakistan from July 2021 to April 2022. A total of 216 patients were enrolled. All patients over the age of 30 years with primary osteoarthritis were included. Association of C-reactive protein and erythrocyte sedimentation rate with OA grade and highest score in case of multiple joints were checked by using chi-square test and odds ratio. Results: Most were females and large group of individuals were overweight or obese. Mean BMI was 29.50 ± 4.94 kg/m². The radiographic progression of OA was seen more in women compared to men for Grade 4 OA. The systemic inflammatory markers erythrocyte sedimentation rate and C-reactive protein were plotted against the Grade of OA and it was found that erythrocyte sedimentation rate was elevated in (n=118) most individuals however C-reactive protein was normal in the majority (n=196). Radiographic advancement of OA with the rise of these acute phase reactants was not significant i.e. p-value was 0.804 for erythrocyte sedimentation rate and 0.497 for C-reactive protein. Conclusion: There was no significant correlation between raised inflammatory markers and radiographic progression of osteoarthritis.

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