Frequency of Dengue and Malaria Co-Infection in Patients Admitted in Jinnah Hospital, Lahore
Dengue and Malaria Co-Infection
DOI:
https://doi.org/10.54393/pjhs.v5i03.1327Keywords:
Co- Infection, Dengue Fever, Malarial Parasite, Thrombocytopenia, Liver FunctionAbstract
Prevalence of malaria and dengue infection coexistence is increasing during endemic periods although causing quite similar symptoms and signs, the treatment of these two illnesses is different. Any suspicion of malaria in disease-endemic areas must be excluded with microscopy and/or rapid antigen test. Objective: To find out the incidence of co-infection of dengue and malaria based on clinical and hematological parameters in patients presenting with acute febrile illness. Methods: This cross-sectional study was done in the Medicine Unit of Jinnah hospital, Lahore from October - December 2022. 140 diagnosed as dengue fever by Non-Structural Protein 1 (NS1) and IgM were included in the study. All the cases were subject to a thorough medical examination i.e. complete battery summary of temperature together with the serology of Dengue, X-ray of the chest, abdominal ultrasound scan, renal function test (RFT), liver function test (LFT), malarial parasite slide, complete blood count with peripheral smear etc. Accordingly, the treatment was given to them with follow-up medical evaluation including detailed investigations. Data were entered and analyzed in SPSS version. 27.0 and presented as frequency and percentages. Chi square test was used to assess statistical significance with P < .05. Results: Mean age of respondent was 35.5 + 15.6 years. Co-infection rate with malaria and severe disease along with prolong duration fever and persistent thrombocytopenia among subjects was15.0%. Conclusions: Majority of co infected individuals were having severe disease, with subsequent development of disseminated intravascular coagulation and sepsis, responding well to anti-malarial treatments
References
WHO. Dengue and Severe Dengue. 2023. [Last Cited: 19th Mar 2024]. Available at: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue.
Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL et al. The global distribution and burden of dengue. Nature. 2013 Apr ;496(7446): 504-7. doi: 10.1038/nature12060. DOI: https://doi.org/10.1038/nature12060
Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLOS Neglected Tropical Diseases. 2017 Aug; 6(8): e1760. doi: 10.1371/journal.pntd.0001760. DOI: https://doi.org/10.1371/journal.pntd.0001760
WHO. Malaria-Pakistan. 2022. [Last Cited: 19th Mar 2024]. Available at: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON413
Abdul-Ghani R, Mahdy MA, Alkubati S, Al-Mikhlafy AA, Alhariri A, Das M et al. High proportion of febrile outpatients with dengue or malaria, but low proportion co-infected. PLoS One. 2021 Jun; 16(6): e0253556. doi: 10.1371/journal.pone.0253556. DOI: https://doi.org/10.1371/journal.pone.0253556
Sahu PS, Sahu M, Ambu S. A review of concurrent infections of malaria and dengue in Asia. Asian Pacific Journal of Tropical Biomedicine. 2016 Jul; 6(7): 633-8. doi: 10.1016/j.apjtb.2016.05.008. DOI: https://doi.org/10.1016/j.apjtb.2016.05.008
Shanks GD and White NJ. The activation of vivax malaria hypnozoites by infectious diseases. The Lancet Infectious Diseases. 2013 Oct; 13(10): 900-6. doi: 10.1016/S1473-3099(13)70095-1. DOI: https://doi.org/10.1016/S1473-3099(13)70095-1
Waggoner J, Brichard J, Mutuku F, Ndenga B, Heath CJ, Mohamed-Hadley A et al. Malaria and Chikungunya Detected Using Molecular Diagnostics Among Febrile Kenyan Children. Open Forum Infect Dis. 2017 May; 4(3): ofx110. doi: 10.1093/ofid/ofx110. DOI: https://doi.org/10.1093/ofid/ofx110
Sam IC and AbuBakar S. Chikungunya virus infection. Medical Journal of Malaysia. 2006 Jun; 61(2): 264-9.
Carme B, Matheus S, Donutil G, Raulin O, Nacher M, Morvan J. Concurrent dengue and malaria in Cayenne hospital, French Guiana. Emerging Infectious Diseases. 2009 Apr; 15(4): 668. doi: 10.3201/eid1504.080891. doi: 10.3201/eid1504.080891. DOI: https://doi.org/10.3201/eid1504.080891
Alsedig K, Eldigail MH, Elduma AH, Elaagip A, Altahir O, Siam HA et.al. Prevalence of malaria and dengue co-infections among febrile patients during dengue transmission season in Kassala, eastern Sudan. PLOS Neglected Tropical Diseases. 2023 Oct; 17(10): e0011660. doi: 10.1371/journal.pntd.0011660. DOI: https://doi.org/10.1371/journal.pntd.0011660
Halsey ES, Baldeviano GC, Edgel KA, Vilcarromero S, Sihuincha M, Lescano AG. Symptoms and immune markers in Plasmodium/dengue virus co-infection compared with mono-infection with either in Peru. PLOS Neglected Tropical Diseases. 2016 Apr; 10(4): e0004646. doi: 10.1371/journal.pntd.0004646. DOI: https://doi.org/10.1371/journal.pntd.0004646
MK J, Rajendran R, Samuel PP. Dual infection by dengue virus and Plasmodium vivax in Alappuzha District, Kerala, India. Japanese Journal of Infectious Diseases. 2006 Jun; 59(3): 211-2. doi: 10.7883/yoken.JJID.2006.211. DOI: https://doi.org/10.7883/yoken.JJID.2006.211
Bhalla A, Sharma N, Sharma A, Suri V. Concurrent infection with dengue and malaria. Indian Journal of Medical Sciences. 2006 Aug; 60(8): 330-1. doi: 10.4103/0019-5359.26610. DOI: https://doi.org/10.4103/0019-5359.26610
Gundikeri SK and Dhananjaya M. Acute undifferentiated febrile illness-clinical spectrum and outcome from a tertiary care teaching hospital of north Karnataka. International Journal of Biological and Medical Research 2013; 4(2): 3399-402.
Singh R, Singh SP, Ahmad N. A study of etiological pattern in an epidemic of acute febrile illness during monsoon in a tertiary health care institute of Uttarakhand, India. Journal of Clinical and Diagnostic Research: JCDR. 2014 Jun; 8(6): MC01. doi: 10.7860/JCDR/2014/8965.4435. DOI: https://doi.org/10.7860/JCDR/2014/8965.4435
Zaki SA. Malaria and dengue co-infection. Annals of Indian Academy of Neurology. 2011 Apr; 14(2): 141-2. doi: 10.4103/0972-2327.82821. DOI: https://doi.org/10.4103/0972-2327.82821
Gebremariam TT, Schallig HD, Kurmane ZM, Danquah JB. Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies. Malaria Journal. 2023 Oct; 22(1): 300. doi: 10.1186/s12936-023-04771-4. DOI: https://doi.org/10.1186/s12936-023-04771-4
Bhakhri BK, Singh DK, Singh N, Rai R. Does malaria co-infection alter the clinical course in children infected with dengue? Analysis from 623 Indian children admitted with dengue infection. Journal of Tropical Pediatrics. 2021 Apr; 67(2): fmab006. doi: 10.1093/tropej/fmab006. DOI: https://doi.org/10.1093/tropej/fmab006
Kotepui M, Kotepui KU, Milanez GD, Masangkay FR. Prevalence of and risk factors for severe malaria caused by Plasmodium and dengue virus co-infection: a systematic review and meta-analysis. Infectious Diseases of Poverty. 2020 Dec; 9:1-4. doi: 10.1186/s40249-020-00741-z. DOI: https://doi.org/10.1186/s40249-020-00741-z
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