Left Ventricular Ejection Fraction among Patients with Acute Myocardial Infarction: Left Ventricular Ejection Fraction: Acute Myocardial Infarction

Maheer Nayyar; Zafar Iqbal; Zubair Ashraf; Naif Usman Saigol; Usman Ghani Choudhary; Naeem Shahzad; Ayesha Tariq

doi:10.54393/pjhs.v7i3.3396

Authors

Maheer Nayyar Department of Cardiology, Mayo Hospital, Lahore, Pakistan
Zafar Iqbal Department of Cardiology, Shahida Islam Medical College, Lodhran, Pakistan
Zubair Ashraf Department of Cardiology, Hamid Latif Teaching Hospital, Lahore, Pakistan
Naif Usman Saigol Department of Family Medicine, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan
Usman Ghani Choudhary Department of Family Medicine, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan
Naeem Shahzad Department of Cardiology, Sulaiman Al Habib Medical Group, Jeddah, Saudia Arabia
Ayesha Tariq Department of Cardiology, Mayo Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v7i3.3396

Keywords:

Left Ventricular Ejection Fraction, Acute Myocardial Infarction, ST-Elevation Myocardial Infarction, Morbidity

Abstract

After an acute myocardial infarction (AMI), the LVEF may be used for prognosis and therapy purposes. Despite the importance of left ventricular ejection fraction (LVEF) testing as a performance indicator for AMI patients, nothing is known about the current rates of in-hospital assessment or how it relates to therapeutic utilization. Objective: To ascertain the prevalence of LVEF patterns in individuals with AMI. Methods: It was a cross-sectional descriptive study conducted at the Department of Cardiology, King Edward Medical University/ Affiliated Hospital, Lahore, from March 2025 to September 2025 under IRB number 783/RC/KEMU. A total of 110 patients were enrolled through nonprobability purposive sampling. Data analysis was done on SPSS version 26.0. Quantitative variables were presented as mean ± S.D. Qualitative variables, i.e., gender, types of myocardial infarction (STEMI/ NSTEMI), and patterns of left ventricular function (Abnormal/ moderately to severely impaired) were presented as frequency and percentage. Results: The average age of the cases in this study was 52.74 ± 8.08 years. There were 72 (65.5%) males and 38 (34.5%) females enrolled in this study. The mean BMI, LVEF, and duration of MI were 27.62 ± 4.27 (kg/m²), 35.30 ± 7.88 (%), and 176.18 ± 5.65 (minutes). There were 35 (31.8%) patients diagnosed with STEMI and 75 (68.2%) diagnosed with NSTEMI. There were 40 (36.4%) patients found with abnormal LVEF patterns and 70 (63.6%) with moderately to severely impaired LVEF. Conclusion: The results of this study showed that the majority of patients with acute MI had moderately to severely impaired LVEF.

References

Ito H, Masuda J, Kurita T, Ida M, Yamamoto A, Takasaki A et al. Effect of Left Ventricular Ejection Fraction on the Prognostic Impact of Chronic Total Occlusion in A Non-Infarct-Related Artery in Patients With Acute Myocardial Infarction. International Journal of Cardiology: Heart and Vasculature. 2021 Apr; 33: 100738. doi: 10.1016/j.ijcha.2021.100738.

Qingqing LI, Dajun CH, Wenxiang ZH, Hailin ZH, Yimin LI, Xiaoyan LI. The Prognostic Value of Left Ventricular Global Function Index in Patients with Acute Myocardial Infarction. Journal of Clinical Cardiology. 2024 May; 40(5): 383-7.

Liu Y, Song J, Wang W, Zhang K, Qi Y, Yang J et al. Association of Ejection Fraction with Mortality and Cardiovascular Events in Patients with Coronary Artery Disease. European Society of Cardiology Heart Failure. 2022 Oct; 9(5): 3461-8. doi: 10.1002/ehf2.14063.

Steffen HJ, Schupp T, Abumayyaleh M, Kuhn L, Steinke P, Dudda J et al. Left Ventricular Ejection Fraction Predicts Outcomes in Different Subgroups of Patients Undergoing Coronary Angiography. Journal of Clinical Medicine. 2025 Jul; 14(15): 5219. doi: 10.3390/jcm14155219.

Yehia A, Zaki A, Sadaka M, Azeem AM. Incremental Prognostic Value of Speckle Tracking Echocardiography and Early Follow‐Up Echo Assessment In Predicting Left Ventricular Recovery After Reperfusion for ST‐Segment Elevation Myocardial Infarction (STEMI). Echocardiography. 2024 Jan; 41(1): e15725. doi: 10.1111/echo.15725.

Wang S, Cheng S, Zhang Y, Lyu Y, Liu J. Extent of Ejection Fraction Improvement After Revascularization Associated with Outcomes among Patients with Ischemic Left Ventricular Dysfunction. International Journal of General Medicine. 2022 Sep; 15: 7219. doi: 10.2147/IJGM.S380276.

Ursaru AM, Petris AO, Costache II, Nicolae A, Crisan A, Tesloianu ND. Implantable Cardioverter Defibrillator in Primary and Secondary Prevention of SCD—What We Still Don′ t Know. Journal of Cardiovascular Development and Disease. 2022 Apr; 9(4): 120. doi: 10.3390/jcdd9040120.

Younis A and Wilkoff BL. Implantable Cardioverter-Defibrillator for Primary Prevention in Asia. Journal of the American College of Cardiology: Asia. 2023 Jun; 3(3_Part_1): 321-34. doi: 10.1016/j.jacasi.2022.11.014.

Wilcox JE, Fang JC, Margulies KB, Mann DL. Heart Failure with Recovered Left Ventricular Ejection Fraction: JACC Scientific Expert Panel. Journal of the American College of Cardiology. 2020 Aug; 76(6): 719-34. doi: 10.1016/j.jacc.2020.05.075.

Wohlfahrt P, Jenča D, Melenovský V, Šramko M, Kotrč M, Želízko M et al. Trajectories and Determinants of Left Ventricular Ejection Fraction After the First Myocardial Infarction in the Current Era of Primary Coronary Interventions. Frontiers in Cardiovascular Medicine. 2022 Nov; 9: 1051995. doi: 10.3389/fcvm.2022.1051995.

Sciaccaluga C, Mandoli GE, Ghionzoli N, Anselmi F, Dini CS, Righini F et al. Risk Stratification in Cardiogenic Shock: A Focus on the Available Evidence. Heart Failure Reviews. 2022 Jul; 27(4): 1105-17. doi: 10.1007/s10741-021-10140-7.

Jenča D, Melenovský V, Stehlik J, Staněk V, Kettner J, Kautzner J et al. Heart Failure After Myocardial Infarction: Incidence and Predictors. European Society of Cardiology: Heart Failure. 2021 Feb; 8(1): 222-37. doi: 10.1002/ehf2.13144.

Zamora E, González B, Lupón J, Borrellas A, Domingo M, Santiago-Vacas E et al. Quality of Life in Patients with Heart Failure and Improved Ejection Fraction: One-Year Changes and Prognosis. European Society of Cardiology: Heart Failure. 2022 Dec; 9(6): 3804-13. doi: 10.1002/ehf2.14098.

Pabon MA, Vaduganathan M, Claggett BL, Chatur S, Siqueira S, Marti‐Castellote P et al. In‐Hospital Course of Patients with Heart Failure with Improved Ejection Fraction in the Deliver Trial. European Journal of Heart Failure. 2024 Dec; 26(12): 2532-40. doi: 10.1002/ejhf.3410.

Barriault A, Iftikhar U, Stone JA. Cardiac Rehabilitation and Heart Failure with Reduced Ejection Fraction: Pathophysiology, Benefits, and Precautions. Canadian Journal of Cardiology. 2025 Mar; 41(3): 443-55. doi: 10.1016/j.cjca.2024.10.014.

Wohlfahrt P, Nativi-Nicolau J, Zhang M, Selzman CH, Greene T, Conte J et al. Quality of Life In Patients with Heart Failure with Recovered Ejection Fraction. Journal of the American Medical Association Cardiology. 2021 Aug; 6(8): 957-62. doi: 10.1001/jamacardio.2021.0939.

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Boehm M et al. Corrigendum to: 2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure: Developed by the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure of the European Society of Cardiology (ESC) with the Special Contribution of the Heart Failure Association (HFA) of the ESC. European Heart Journal. 2021 Dec; 42(48): 4901-.

Abovich A, Matasic DS, Cardoso R, Ndumele CE, Blumenthal RS, Blankstein R, Gulati M. The AHA/ACC/HFSA 2022 heart failure guidelines: changing the focus to heart failure prevention. American Journal of Preventive Cardiology. 2023 Sep; 15: 100527. doi: 10.1016/j.ajpc.2023.100527.

Butt JH, Claggett BL, Miao ZM, Jering KS, Sim D, van der Meer P et al. Geographic Differences in Patients with Acute Myocardial Infarction in the PARADISE-MI Trial. European Journal of Heart Failure. 2023 Aug; 25(8): 1228-42. doi: 10.1002/ejhf.2851.

Hendrickson MJ, Arora S, Vaduganathan M, Fonarow GC, Mp G, Bansal A et al. Prevalence and Prognostic Implications of Reduced Left Ventricular Ejection Fraction among Patients with STEMI in India. European Society of Cardiology: Heart Failure. 2022 Dec; 9(6): 3836-45. doi: 10.1002/ehf2.14055.