Prescribing Patterns and Utilization Trends of Anti-Asthmatic Drugs in Children: An Observational Study in a Pediatric Population
Prescribing Patterns and Utilization Trends of Anti-Asthmatic Drugs
DOI:
https://doi.org/10.54393/pjhs.v6i8.3186Keywords:
Asthma, Bronchodilator, Corticosteroids, Anti-Asthmatic, DrugAbstract
Pediatric asthma occurs as a common chronic respiratory illness. Objectives: To evaluate the prescribing patterns and utilization trends of anti-asthmatic medications in pediatric patients, assessing adherence, appropriateness, and factors influencing drug selection. Methods: This observational study investigated pediatric asthma patients over six months, collecting data from 160 children aged 4–10 years. The data was obtained from pediatric asthma patients about their demographic information, alongside their asthma severity status and medication choices, and delivery methods. Data were analyzed by SPSS version 21.0. Chi-square test evaluated all associations between variables. Results: The study included 160 patients, with 31.3% of them within the age range of 8–9 years, and males represented 56.3% of the group. Urban residents (62.5%) were more affected. The bronchodilator medicine Salbutamol received the highest prescription rate (56.3%), and Budesonide held the position as the most commonly chosen corticosteroid (31.3%). The usage rate of Montelukast reached 45.0% while Theophylline's prescription was limited to just 11.3% of patients. The primary choice of medication delivery involved nebulization for 53.1% of patients, whereas 31.3% received inhalers and 15.6% had oral administration. The standard treatment for mild asthma patients involved Montelukast at a rate of 37.5% and Budesonide treated 34.4% of moderate cases, while severe asthma patients received Salbutamol + Ipratropium in 28.1% of cases. Conclusions: Prescribing patterns in pediatric asthma were closely linked to disease severity, with increased use of nebulizers and combination therapies in severe cases. Tailored, severity-based management can enhance treatment outcomes and promote rational drug use in children.
References
Papi A, Blasi F, Canonica GW, Morandi L, Richeldi L, Rossi A. Treatment Strategies for Asthma: Reshaping the Concept of Asthma Management. Allergy, Asthma and Clinical Immunology. 2020 Aug; 16(1): 75. doi: 10.1186/s13223-020-00472-8.
Côté A, Godbout K, Boulet LP. The Management of Severe Asthma in 2020. Biochemical Pharmacology. 2020 Sep; 179: 114112. doi: 10.1016/j.bcp.2020.114112.
Rehman N, Morais-Almeida M, Wu AC. Asthma Across Childhood: Improving Adherence to Asthma Management from Early Childhood to Adolescence. The Journal of Allergy and Clinical Immunology: In Practice. 2020 Jun; 8(6): 1802-7. doi: 10.1016/j.jaip.2020.02.011.
Mathioudakis AG, Custovic A, Deschildre A, Ducharme FM, Kalayci O, Murray C, et al. Research Priorities in Pediatric Asthma: Results of A Global Survey of Multiple Stakeholder Groups by The Pediatric Asthma in Real Life (PeARL) Think Tank. The Journal of Allergy and Clinical Immunology: In Practice. 2020 Jun;8(6): 1953-60. doi: 10.1016/j.jaip.2020.01.059.
Kaplan A, Price D. Treatment Adherence in Adolescents with Asthma. Journal of Asthma and Allergy. 2020 Jan;13: 39-49. doi: 10.2147/JAA.S233268.
Cloutier MM, Dixon AE, Krishnan JA, Lemanske RF Jr, Pace W, Schatz M, et al. Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update from the National Asthma Education and Prevention Program. Journal of the American Medical Association. 2020 Dec; 324(22): 2301-17. doi: 10.1001/jama.2020.21974.
Martin J, Townshend J, Brodlie M. Diagnosis and Management of Asthma in Children. BMJ Paediatrics Open. 2022 Apr; 6(1): e001277. doi: 10.1136/bmjpo-2021-001277.
Beasley R, Braithwaite I, Semprini A, Kearns C, Weatherall M, Pavord ID. Optimal Asthma Control: Time for a New Target. American Journal of Respiratory and Critical Care Medicine. 2020 Jun; 201(12): 1480-7. doi: 10.1164/rccm.201910-1934CI.
Cloutier MM, Baptist AP, Blake KV, Brooks EG, Bryant-Stephens T, DiMango E, et al. Focused Updates to The Asthma Management Guidelines: A Report from The National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. Journal of Allergy and Clinical Immunology. 2020 Dec; 146(6): 1217-70. doi: 10.1016/j.jaci.2020.10.003.
Ramsey RR, Plevinsky JM, Kollin SR, Gibler RC, Guilbert TW, Hommel KA. Systematic Review of Digital Interventions for Pediatric Asthma Management. The Journal of Allergy and Clinical Immunology: in Practice. 2020 Apr; 8(4): 1284-93. doi: 10.1016/j.jaip.2019.12.013.
Venkatesan P. 2025 GINA Report for Asthma. The Lancet Respiratory Medicine. 2025 Aug;13(8): e41-2. doi: 10.1016/S2213-2600(25)00242-5.
Zhou W and Tang J. Prevalence and Risk Factors for Childhood Asthma: A Systematic Review and Meta-Analysis. BMC Pediatrics. 2025 Jan; 25(1): 50. doi: 10.1186/s12887-025-05409-x.
Pakkasela J, Ilmarinen P, Honkamäki J, Tuomisto LE, Andersén H, Piirilä P, et al. Age-Specific Incidence of Allergic and Non-Allergic Asthma. BMC Pulmonary Medicine. 2020 Jan; 20(1): 9. doi: 10.1186/s12890-019-1040-2.
Paciência I and Rufo JC. Urban-Level Environmental Factors Related to Pediatric Asthma. Porto Biomedical Journal. 2020 Jan;5(1): e57. doi: 10.1097/j.pbj.0000000000000057.
Chatkin J, Correa L, Santos U. External Environmental Pollution as A Risk Factor for Asthma. Clinical Reviews in Allergy and Immunology. 2022 Feb; 62(1): 72-89. doi: 10.1007/s12016-020-08830-5.
Marques L and Vale N. Salbutamol in The Management of Asthma: A Review. International Journal of Molecular Sciences. 2022 Nov;23(22): 14207. doi: 10.3390/ijms232214207.
Kawamatawong T, Sangasapaviriya A, Saiphoklang N, Oer-Areemitr N, Sriprasart T, Kamalaporn H, et al. Guidelines for the Management of Asthma in Adults: Evidence and Recommendations. Asian Pacific Journal of Allergy and Immunology. 2022 Mar; 40(1): 1-21.
Leung JS. Paediatrics: How To Manage Acute Asthma Exacerbations. Drugs In Context. 2021 May; 10: 2020-12. doi: 10.7573/dic.2020-12-7.
Abdelfattah AM, Sarhan RM, Madney YM, Mady AF, Abdelrahim M, Harb HS. Add-on Inhalation Devices Correlation and Influence on Asthmatic Patients. Bulletin of Pharmaceutical Sciences Assiut University. 2025 Jun; 48(1): 401-20.
Abougalambou SS, Albarrak GS, Abougalambou AS. Assessing the Use of MDI Among Asthmatic Patients in Saudi Arabia. Pharmacy Practice. 2022 Jan; 20(1): 2604. doi: 10.18549/PharmPract.2022.1.2604.
Mayoral K, Lizano-Barrantes C, Zamora V, Pont A, Miret C, Barrufet C, et al. Montelukast in Paediatric Asthma and Allergic Rhinitis: A Systematic Review and Meta-Analysis. European Respiratory Review. 2023 Oct; 32(170). doi: 10.1183/16000617.0124-2023.
Kim LH, Saleh C, Whalen-Browne A, O'Byrne PM, Chu DK. Triple Vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-Analysis. Journal of the American Medical Association. 2021 Jun; 325(24): 2466-79. doi: 10.1001/jama.2021.7872.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Pakistan Journal of Health Sciences

This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments