Comparison between Oral Nifedipine and Intravenous Labetalol in Managing Severe Preeclampsia: Oral Nifedipine and Intravenous Labetalol in Managing Severe Preeclampsia

Ayesha Siddiqua; Anila Sabir; Nadia Siddique; Faraz Bakht; Hina Rauf; Hania Zafar

doi:10.54393/pjhs.v6i5.3026

Authors

Ayesha Siddiqua Department of Gynaecology and Obstetrics, Lady Willingdon Hospital, Lahore, Pakistan
Anila Sabir Department of Gynaecology and Obstetrics, Abu Umara Medical and Dental College, Ali Fatima Hospital, Lahore, Pakistan
Nadia Siddique Department of Gynaecology and Obstetrics, District Headquarters Hospital, Hafizabad, Pakistan
Faraz Bakht Department of Gynaecology and Obstetrics, Sahara Medical College, Sughra Teaching Hospital, Narowal, Pakistan
Hina Rauf Department of Gynaecology and Obstetrics, Abu Umara Medical and Dental College, Ali Fatima Hospital, Lahore, Pakistan
Hania Zafar Department of Gynaecology and Obstetrics, Abu Umara Medical and Dental College, Ali Fatima Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i5.3026

Keywords:

Severe Preeclampsia, Oral Nifedipine, Intravenous Labetalol, Hypertensive Disorders

Abstract

Hypertensive disorders contribute to significant maternal morbidity and mortality in pregnancy. Immediate treatment is required to avoid serious complications. Objectives: To compare the mean time taken to achieve the target BP with oral nifedipine versus intravenous labetalol in patients with severe preeclampsia. Methods: This quasi-experimental study was conducted at Lady Willington Hospital, Lahore, over six months after taking approval from CPSP, involving 100 patients diagnosed with severe preeclampsia. Participants were divided into two equal groups: Group oral nifedipine and IV labetalol. Study outcome time taken to reach target BP <140/90 mmHg was compared among groups using an independent sample test, with a p-value≤ 0.05 as significant. Results: Target BP was achieved earlier at 43.96 ± 5.93 minutes with oral nifedipine compared to IV labetalol at 48.60 ± 6.80 minutes (p<0.001). Conclusions: It was concluded that the findings strongly support the use of nifedipine as a more effective option for rapidly lowering blood pressure compared to labetalol. Its faster onset of action makes it the preferred choice for achieving timely blood pressure control in patients with severe preeclampsia.

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