Impact of Dengue Fever on Pregnancy Outcomes: A Prospective Observational Study
Impact of Dengue Fever on Pregnancy Outcomes
DOI:
https://doi.org/10.54393/pjhs.v6i1.2742Keywords:
Pregnancy, Dengue Fever, Maternal outcome, Fetal outcome, Preterm delivery, Fetal growth restriction, StillbirthAbstract
Dengue in pregnancy has a profound negative impact on both maternal and fetal outcomes, leading to increased maternal and neonatal mortality. Objective: To evaluate the maternal and fetal outcomes in pregnant women affected by dengue fever. Methods: A prospective observational study was carried out at Niazi Welfare Foundation Teaching Hospital, Sargodha. Non probability convenient sampling technique was used to collect data from 36 pregnant women enrolled after confirming dengue infection through NS-1 and IgM/IgG tests. Maternal and fetal outcomes were monitored throughout pregnancy, labor, and the postpartum period. Data was analyzed using SPSS version 26.0 and presented in frequency and percentages. Results: Fetal complications observed in this study were, preterm delivery in 16 cases (44.4%), term delivery in 14 cases (39%), fetal growth restriction in 8 cases (22%), and intrauterine death in 6 cases (16.6%). Maternal outcomes included, postpartum hemorrhage in 6 cases (16.6%), 7 infected women (19.4%) were admitted to the ICU, and two mothers (5.5%) died. The frequency of neonatal admission to the NICU was 30.5%. Conclusions: Dengue infection in pregnancy is linked to heightened risk of maternal and perinatal morbidity and mortality. Timely clinical interventions are necessary to avoid devastating consequences.
References
Manikandan S, Mathivanan A, Bora B, Hemaladkshmi P, Abhisubesh V, Poopathi S. A Review on Vector Borne Disease Transmission: Current Strategies of Mosquito Vector Control. Indian Journal of Entomology. 2023 Jun 1: 503-13. doi: 10.55446/IJE.2022.593. DOI: https://doi.org/10.55446/IJE.2022.593
Powell JR. Mosquito-Borne Human Viral Diseases: Why Aedes Aegypti?. The American Journal of Tropical Medicine and Hygiene. 2018 Jun; 98(6): 1563. doi: 10.4269/ajtmh.17-0866. DOI: https://doi.org/10.4269/ajtmh.17-0866
Mulik V, Dad N, Buhmaid S. Dengue in Pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2021 Jun; 261: 205-10. doi: 10.1016/j.ejogrb.2021.04.035. DOI: https://doi.org/10.1016/j.ejogrb.2021.04.035
Jatoi SA, Lakhan S, Rani N. Impact of Dengue Fever on Feto-Maternal Outcomes: A Retrospective Study. Journal of Pharmaceutical Negative Results. 2022 Dec: 4306-10. doi: 10.47750/pnr.2022.13.S09.536
Tissera H, Wijewickrama A, Weeraman J, Ghouse A, Kaluarachchi A, Fernando L et al. Clinical Management of Dengue Infection in Pregnancy. Ceylon Medical Journal. 2020 Dec; 65(4). doi: 10.4038/cmj.v65i4.9275. DOI: https://doi.org/10.4038/cmj.v65i4.9275
Brar R, Sikka P, Suri V, Singh MP, Suri V, Mohindra R et al. Maternal and Fetal Outcomes of Dengue Fever in Pregnancy: A Large Prospective and Descriptive Observational Study. Archives of Gynecology and Obstetrics. 2021 Jul; 304: 91-100. doi: 10.1007/s00404-020-05930-7. DOI: https://doi.org/10.1007/s00404-020-05930-7
Rahman F, Hossain DL, Ganguly S, Tawhida FN, Nahar LK. Dengue Fever in Pregnancy-Maternal and Fetal Outcome. Journal of Bangladesh College of Physicians and Surgeons. 2023 Nov 28: 21-4. doi: 10.3329/jbcps.v41i40.69678 DOI: https://doi.org/10.3329/jbcps.v41i40.69678
Wilson AL, Courtenay O, Kelly-Hope LA, Scott TW, Takken W, Torr SJ, Lindsay SW. The Importance of Vector Control for the Control and Elimination of Vector-Borne Diseases. Plos Neglected Tropical Diseases. 2020 Jan; 14(1): e0007831. doi: 10.1371/journal.pntd.0007831. DOI: https://doi.org/10.1371/journal.pntd.0007831
Bhardwaj D, Chawla S, Sahoo I, Rathore P, Sharma A, Siddique N. Dengue in Pregnancy. Medical Journal of Dr. DY Patil University. 2020 May; 13(3): 264-7. doi: 10.4103/mjdrdypu.mjdrdypu_195_19. DOI: https://doi.org/10.4103/mjdrdypu.mjdrdypu_195_19
Srisawat N, Thisyakorn U, Ismail Z, Rafiq K, Gubler DJ, ADVA-ISNTD World Dengue Day Committee. World Dengue Day: A Call or Action. Plos Neglected Tropical Diseases. 2022 Aug; 16(8): e0010586. doi: 10.1371/journal.pntd.0010586. DOI: https://doi.org/10.1371/journal.pntd.0010586
Garg R, Malhotra N, Pathak A, Singh D, Agrawal P, Gautam A. Maternal and Perinatal Outcome in Dengue Fever in Pregnancy in North India. Journal Of South Asian Federation of Obstetrics and Gynaecology. 2021 Nov; 13(6). doi: 10.5005/jp-journals-10006-1978. DOI: https://doi.org/10.5005/jp-journals-10006-1978
Singkibutr T, Wuttikonsammakit P, Chamnan P. Effects of Dengue Infection on Maternal and Neonatal Outcomes in Thai Pregnant Women: A Retrospective Cohort Study. J. Med. Assoc. Thai. 2020; 103: 155–162.
Ginige S, Flower R, Viennet E. Neonatal Outcomes from Arboviruses in the Perinatal Period: A State-Of-The-Art Review. Pediatrics. 2021 Apr; 147(4). doi: 10.1542/peds.2020-009720. DOI: https://doi.org/10.1542/peds.2020-009720
Chong V, Tan JZ, Arasoo VJ. Dengue in Pregnancy: A Southeast Asian Perspective. Tropical Medicine and Infectious Disease. 2023 Jan; 8(2): 86. doi: 10.3390/tropicalmed8020086. DOI: https://doi.org/10.3390/tropicalmed8020086
Sondo KA, Ouattara A, Diendere EA, Diallo I, Zoungrana J, Zemane G et al. Dengue Infection During Pregnancy in Burkina Faso: A Crosssectional Study. BMC Infect Dis. 2019; 19: 997. doi: 10.1186/s12879- 019-4587-x. DOI: https://doi.org/10.1186/s12879-019-4587-x
Shoaib MA, Sohail Tareen M, Afridi UZ, Saifullah SA. Maternal and Neonatal Outcomes in Pregnant Women with Dengue. Pak J Med Health Sci. 2021; 15: 3161-. doi: 10.53350/pjmhs2115113161. DOI: https://doi.org/10.53350/pjmhs2115113161
Mubashir M, Ahmed KS, Mubashir H, Quddusi A, Farooq A, Ahmed SI et al. Dengue and Malaria Infections in Pregnancy: Maternal, Fetal and Neonatal Outcomes at a Tertiary Care Hospital. Wiener klinische Wochenschrift. 2020 Apr; 132: 188-96. doi: 10.1007/s00508-019-01606-8. DOI: https://doi.org/10.1007/s00508-019-01606-8
Nallaperuma OL, Senanayake HM, Godevithana JC. Adverse Outcomes and Associations of Dengue in Pregnancy–A Retrospective Cohort Study. medRxiv. 2024 Apr 10: 2024-04. doi: 10.1101/2024.04.07.24304931. DOI: https://doi.org/10.1101/2024.04.07.24304931
Rathore SS, Oberoi S, Hilliard J, Raja R, Ahmed NK, Vishwakarma Y et al. Maternal and Foetal‐Neonatal Outcomes of Dengue Virus Infection During Pregnancy. Tropical Medicine & International Health. 2022 Jul; 27(7): 619-29. doi: 10.1111/tmi.13783. DOI: https://doi.org/10.1111/tmi.13783
Sagili H, Krishna RS, Dhodapkar R, Keepanasseril A. Maternal & Perinatal Outcome of Fever in Pregnancy in the Context of Dengue-A Retrospective Observational Study. Indian Journal of Medical Research. 2022 Oct 1; 156(4&5): 619-23. doi: 10.4103/ijmr.IJMR_414_20. DOI: https://doi.org/10.4103/ijmr.IJMR_414_20
Jahan I, Alam LC, Akter S. Dengue in Pregnancy a Systemic Review and Meta analysis of Maternal and Perinatal Outcomes. IAR Journal of Medicine and Surgery Research. 2024 Nov; 5(6): 41-9. doi: 10.70818/iarjmsr.2024.v05i06.0143. DOI: https://doi.org/10.70818/iarjmsr.2024.v05i06.0143
Duarte G, Braga AR, Kreitchmann R, Menezes ML, Miranda AE, Travassos AG et al. Prevention, Diagnosis, and Treatment Protocol of Dengue During Pregnancy and the Postpartum Period. Revista Brasileira De Ginecologia E Obstetrícia. 2024 Jul; 46: e-rbgo73. oi: 10.61622/rbgo/2024rbgo73. DOI: https://doi.org/10.61622/rbgo/2024rbgo73
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Pakistan Journal of Health Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments
