Renal Function Status in Patients with Diabetes Mellitus Having Diabetic Foot Infection and Role of Antibiotics

Renal Function Status in Patients with Diabetes Mellitus

Authors

  • Shabab Hussain Khyber Medical University Institute of Medical Sciences, Kohat, Pakistan
  • . Arrham Department of General surgery, Dr Akbar Niazi Teaching Hospital, Islamabad, Pakistan
  • Syeda Javeriya Saeed Khyber Medical University Institute of Medical Sciences, Kohat, Pakistan
  • Ahmad Murtaza Anwar Divisional Headquarters Teaching Hospital Mirpur, AJK, Pakistan
  • Asif Khan Jinnah Teaching Hospital, Peshawar, Pakistan
  • Saifullah Brohi Bilawal Medical College for Boys LUMHS, Jamshoro, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v3i05.265

Keywords:

Diabetic foot, Infection, Glomerular filtration rate and Antibiotics

Abstract

It has been shown that antibiotic therapy in diabetic foot ulcers has a toxic effect on renal function. Objective: To assess the renal function among patients with diabetes mellitus having diabetic foot infection. Methods: It was a cross-sectional retrospective study in the surgical Unit of DHQ Teaching Hospital KDA Kohat for six-month duration from January 2022 to June 2022. 130 patients with diabetic foot ulcers were selected for this study. The patients receiving antibiotic with a low renal toxicity risk were included in Group-A and patients receiving antibiotics with an increased renal toxicity risk were included in group B. GFR was calculated and measured from Cockcroft-Gault equation and serum creatinine levels. SPSS 20.0 was applied for data analysis with paired t-tests, t-test and chi-square tests.

Results: In group A there were 65 (50%) participants and 65 (50%) in group B. GFR after and before antibiotic therapy was 58.30±31.13 cm3 / min and 65.98±35.76 cm3 / min (p = 0.004), correspondingly. The GFR in group B was reduced significantly after antibiotic therapy (p = 0.003). Conclusions: Conferring to this study, renal function decreased and nephrotoxicity was noted after antibiotic treatment, the percentage of decline in GFR being greater in patients who received higher nephrotoxic antibiotics.

References

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Published

2022-10-31
CITATION
DOI: 10.54393/pjhs.v3i05.265
Published: 2022-10-31

How to Cite

Hussain, S. ., Arrham, ., Javeriya Saeed, S. ., Murtaza Anwar, A. ., Khan, A. ., & Brohi, S. . (2022). Renal Function Status in Patients with Diabetes Mellitus Having Diabetic Foot Infection and Role of Antibiotics: Renal Function Status in Patients with Diabetes Mellitus. Pakistan Journal of Health Sciences, 3(05), 189–193. https://doi.org/10.54393/pjhs.v3i05.265

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