Evaluation of Glycated Hemoglobin Levels in Cirrhotic Patients Across Different Child-Pugh Classes : Glycated Hb Levels in Cirrhotic Patients Across Child-Pugh Classes

Rabia Qayoom Shaikh; Mukhtair Hussain Jafferi; Abdul Ghaffar Daras; Sobia Karamullah; Fouzia Shaikh; Imran Ali Shaikh

doi:10.54393/pjhs.v6i3.2606

Authors

Rabia Qayoom Shaikh Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Mukhtair Hussain Jafferi Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Abdul Ghaffar Daras Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Sobia Karamullah Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Fouzia Shaikh Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
Imran Ali Shaikh Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i3.2606

Keywords:

Chronic Liver Disease, Diabetes, HbA1c Levels, Child-Pugh Classification

Abstract

Chronic liver diseases can lead to cirrhosis, characterized by structural abnormalities and fibrosis. Diabetes is a significant risk factor for poor prognosis in cirrhotic patients, associated with complications such as ascites, renal dysfunction, and increased mortality. Objectives: To evaluate glycated hemoglobin (HbA1c) levels in cirrhotic patients across different Child-Pugh classes, contributing to better management of chronic liver disease. Methods: Conducted at Liaquat University of Medical and Health Sciences, this descriptive cross-sectional study enrolled 62 cirrhotic patients (aged 18-60) over six months. Exclusion criteria included known diabetes and recent blood transfusions. Data on demographic characteristics and HbA1c levels were collected and analyzed using SPSS version 24.0. Results: The mean age of participants was 52.3 ± 7.5 years, with a mean disease duration of 28.4 ± 12.3 months. The overall mean HbA1c level was 5.3 ± 0.9%. Child-Pugh classification revealed 32% Class A, 40% Class B, and 28% Class C patients. HbA1c levels increased significantly with liver disease severity: Class A (4.9 ± 0.6%), Class B (5.4 ± 0.7%), and Class C (5.9 ± 0.8%), p<0.05. Significant associations were found between HbA1c levels and age, disease duration, but not with gender or BMI. Conclusions: It was concluded that HbA1c levels are influenced by the severity of liver disease and duration, indicating the need for careful interpretation of HbA1c in cirrhotic patients for effective management.

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