Clinicopathological Insights to the Nerve Growth Factor NGF Associated Stress Response in Pregnancy and Therapeutic Potential in Fetal Neurodevelopment: Clinicopathological Insights to the Nerve Growth Factor Associated Stress Response in Pregnancy

Tayyaba Siddique; Sahrish Bhutto; Naeemullah Syed; Muhammad Azam Javaid; Ayesha Zubair; Seemi Tanvir; Haseeb Khaliq

doi:10.54393/pjhs.v5i09.2249

Authors

Tayyaba Siddique Department of Gynaecology and Obstetrics, Tehsil Headquarters Hospital Wazirabad, Gujranwala, Pakistan
Sahrish Bhutto Department of Paediatrics, Dr Ziauddin Hospital, Karachi, Pakistan
Naeemullah Syed Department of Neurology, Federal Postgraduate Medical Institute, Lahore, Pakistan
Muhammad Azam Javaid Child Specialist, Hayat Memorial Teaching Hospital, Lahore, Pakistan
Ayesha Zubair Department of Biochemistry, Combined Military Hospital Lahore Medical College and Institute of Dentistry, Lahore, Pakistan
Seemi Tanvir Department of Pathology, Margalla Institute of Health Sciences, Rawalpindi, Pakistan
Haseeb Khaliq Department of Pathology, University of Health Sciences, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i09.2249

Keywords:

Nerve Growth Factor, Pregnancy, Maternal Stress, Fetal Neurodevelopment

Abstract

The nerve growth factor has a significant role in fetal neurogenesis and sustaining pregnancy. Objectives: To investigate the effects of nerve growth factor in stress response during pregnancy on developing fetus to bring clinicopathological correlation on the role of nerve growth factor in maternal stress markers (cortisol levels, glucocorticoids, depression, anxiety, and brain-derived neurotrophic factor levels) and fetal brain development. Methods: Following PRISMA guidelines, this study was extracted from PubMed, ScienceDirect, Nature, and Google Scholar articles from January 2014 to April 2024. The examination of pregnant women in published research gave a possibility to understand the application of nerve growth factor as a suitable biomarker for brain stress and fetal neuronal development. To exclude studies with lower ranks, each of the selected studies was assessed for adherence to evidence-based research methodology. The studies were taken from China, Europe, America and South Asia (including Pakistan). Results: Increased nerve growth factor levels were associated with maternal stress reactions which caused changes in cortisol levels and the amygdaloidal complex area. However, the increased nerve growth factor level was linked to changes in the fetal brain such as the weight of the fetal brain and stress biomarkers in the amniotic fluid sample inferring a critical role in the modulation of maternal stress on the fetal neurodevelopmental spheres. Conclusions: It was concluded that it is important to note how stress and nerve growth factors interact during pregnancy to create effective interventions to reduce stress dependence for the better health of both the mother and child.

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