Sensitivity Pattern of Uropathogens in Diabetic and Non-Diabetic Patients Presenting to a Tertiary Care Hospital: Uropathogen Sensitivity in Diabetic Patients

Muhammad Nisar; Muhammad Waqar Farooq; Asadullah; Nisar Ahmad

doi:10.54393/pjhs.v5i12.2243

Authors

Muhammad Nisar Department of Medicine, Lady Reading Hospital, Peshawar, Pakistan
Muhammad Waqar Farooq Department of Medicine, THQ Doger Hospital, Khyber Pakhtunkhwa, Pakistan
Asadullah Department of Medicine, CAT-D Hospital, Bajur, Khyber Pakhtunkhwa, Pakistan
Nisar Ahmad Department of Medicine, Rural Health Center, Khall, Dir Lower, Khyber Pakhtunkhwa, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i12.2243

Keywords:

Diabetes Mellitus, Urinary Tract Infections, Antibiotic Resistance, Meropenem, Ciprofloxacin

Abstract

Diabetes Mellitus (DM) is a prevalent global health issue, with Pakistan experiencing a high burden. Diabetic patients were more susceptible to Urinary Tract Infections (UTIs) and often exhibit greater antibiotic resistance. Objective: To determine the sensitivity/resistance patterns of DM and Non-DM UTI patients. Methods: A cross-sectional study was conducted on 208-UTI at Lady Reading Hospital, Peshawar, from January to July 2020. Patients were equally divided into DM (n=104) and non-DM (n=104) groups. Results: A total of 208 UTI cases were equally divided between diabetic and non-diabetic groups (104 in each). The mean age of patients was 42.49 ± 1.148 years with a male predominance 132 (63.4%). Dysuria was reported in 81 (38.9%), urinary frequency in 86 (41.3%), and fever in 41 (19.7%) patients. Significant differences were observed in antibiotic resistance patterns between diabetic and non-diabetic groups. Diabetic patients exhibited higher resistance to Meropenem 86 (78%) versus 24 (22%), p<0.001), Ciprofloxacin 95 (98%) versus 2 (2%), p<0.001), and Ceftazidime 93 (79.4%) versus 24(20.6%), p<0.001) compared to non-diabetics. Conversely, sensitivity were significantly lower in diabetic patients for Meropenem (18(18%) versus 80(82%), p<0.001), Ciprofloxacin (9(8%) versus 102(91.8%), p<0.001), and Ceftazidime (11(12.3%) versus 79(87.7%), p<0.001). No significant associations were found between age or gender and antibiotic sensitivity within either group. Conclusion: The study demonstrates that diabetic patients were at significantly higher risk for antibiotic-resistant UTIs, particularly against meropenem, ciprofloxacin, and ceftazidime. These findings highlight the importance of customized antibiotic therapies and better glycemic control in diabetic patients to reduce UTIs complications.

Author Biographies

Muhammad Waqar Farooq, Department of Medicine, THQ Doger Hospital, Khyber Pakhtunkhwa, Pakistan

Asadullah , Department of Medicine, CAT-D Hospital, Bajur, Khyber Pakhtunkhwa, Pakistan

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