Risk Factors of Eclampsia and Its Maternal and Perinatal Effects at A Tertiary Hospital: A Retrospective Study

Risk Factors of Eclampsia and Its Maternal Effects at A Tertiary Hospital

Authors

  • Erum Bano Patel Hospital Karachi, Pakistan
  • Tahmina Mahar Department of Obstetrics and Gynecology, Ghulam Muhammad Mahar Medical College Teaching Hospital Sukkur, Pakistan
  • Pushpa Malhi Department of Obstetrics and Gynecology, Aga khan Maternal and Childcare Center Hyderabad, Pakistan
  • Saira Hashmi Department of Gynecology, Sandeman Provincial Hospital Quetta, Pakistan
  • Anbia Soomro Department of Gynecology, Civil Hospital Hyderabad, Pakistan
  • Sumaira Khoso Department of Gynecology, Bolan Medical College and Hospital Quetta, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v3i05.202

Keywords:

Eclampsia, perinatal mortality, antenatal care, hypertension

Abstract

Eclampsia is responsible for 34% of maternal mortality in Pakistani tertiary care hospitals among women admitted for delivery. Objective: To evaluate risk factors associated with eclampsia patients as well as the perinatal maternal effects in patients. Methods: Overall, 250 patients were involved in this research who were diagnosed with eclampsia. The data were collected from the medical records of the patients. The medical records contained information related to the patient's pregnancy history, characteristics, medical history, obstetric history, information related to admission to the hospital, maternal outcomes, and treatment provided at the hospital. For statistical analysis, SPSS version 21.0 was used. Results: There were 21689 women who gave birth in the hospital during the research process and 250 patients (1.15%) were diagnosed with eclampsia out of which 4 women died and had a case fatality rate of 1.6 %. The major risk factors associated were young age, already existing medical conditions, education level being low, low antenatal attendance, and nulliparity. HELLP syndrome was the most common consequence with a percentage of 15.6. All patients were provided with medication of magnesium sulfate. However, there was an absence of parenteral antihypertensive therapy. A total of 46 women (18.4 %) gave birth through vaginal delivery. Conclusions: According to our findings, eclampsia is still a key risk to maternal survival. Poor socioeconomic status, lack of education, and inadequate antenatal care were found as major risk factors

References

Soomro S, Kumar R, Lakhan H, Shaukat F. Risk Factors for Pre-eclampsia and Eclampsia Disorders in Tertiary Care Center in Sukkur, Pakistan. Cureus. 2019 Nov;11(11): e6115. doi: 10.7759/cureus.6115.

Eiland E, Nzerue C, Faulkner M. Preeclampsia 2012. Journal of pregnancy 2012 Oct.

Canobbio MM. Health care issues facing adolescents with congenital heart disease. Journal of pediatric nursing. 2001 Oct; 16(5):363-70. doi: 10.1053/jpdn.2001.26570.

Mahran A, Fares H, Elkhateeb R, Ibrahim M, Bahaa H, Sanad A, et al. Risk factors and outcome of patients with eclampsia at a tertiary hospital in Egypt. BMC Pregnancy Childbirth. 2017 Dec; 17(1):435. doi: 10.1186/s12884-017-1619-7.

Giordano JC, Parpinelli MA, Cecatti JG, Haddad SM, Costa ML, Surita FG, et al. The burden of eclampsia: results from a multicenter study on surveillance of severe maternal morbidity in Brazil. PLoS One. 2014 May; 9(5):e97401. doi: 10.1371/journal.pone.0097401.

Elnesr NE and Gammo RA. Faeto Maternal and Perinatal Outcome of Patients with Complicated Sever Pre-Eclampsia in Libya 2021.

Mishra PP and Narain B. A prospective case control study to discover and evaluate the significance of the neonatal outcomes of eclamptic mothers. European Journal of Molecular & Clinical Medicine (EJMCM).2020;7(11).

WHO U. UNFPA, the World Bank, and the United Nations Population Division. Trends in maternal mortality: 1990 to 2013. World Health Organization. 2014.

Aali BS, Ghafoorian J, Mohamad-Alizadeh S. Severe preeclampsia and eclampsia in Kerman, Iran: complications and outcomes. Medical science monitor: international medical journal of experimental and clinical research. 2004 Apr;10(4):CR163-7.

Sobande AA, Eskandar M, Bahar A, Abusham A. Severe pre-eclampsia and eclampsia in Abha, the south west region of Saudi Arabia. Journal of Obstetrics and Gynaecology. 2007 Feb; 27(2):150-4. doi: 10.1080/01443610601113961.

Kullberg G, Lindeberg S, Hanson U. Eclampsia in Sweden. Hypertens Pregnancy. 2002; 21(1):13-21. doi: 10.1081/PRG-120002906.

Fallatah AM, Babatin HM, Nassibi KM, Banweer MK, Fayoumi MN, Oraif AM. Maternal and Neonatal Outcomes among Obese Pregnant Women in King Abdulaziz University Hospital: A Retrospective Single-Center Medical Record Review. Medical research archives. 2019 Dec;73(6):425-432. doi: 10.5455/medarh.2019.73.425-432.

Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet. 2010 Aug; 376(9741):631-44. doi: 10.1016/S0140-6736(10)60279-6.

World Health Organization. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia: summary of recommendations. World Health Organization; 2011.

Agida ET, Adeka BI, Jibril KA. Pregnancy outcome in eclamptics at the University of Abuja Teaching Hospital, Gwagwalada, Abuja: a 3-year review. Nigerian journal of clinical practice. 2010;13(4).

Mooij R, Lugumila J, Mwashambwa MY, Mwampagatwa IH, van Dillen J, Stekelenburg J. Characteristics and outcomes of patients with eclampsia and severe pre-eclampsia in a rural hospital in Western Tanzania: a retrospective medical record study. BMC Pregnancy Childbirth. 2015 Sep; 15:213. doi: 10.1186/s12884-015-0649-2.

Mukherjee C. Studies in Toxaemias of Pregnancy. University of Glasgow (United Kingdom); 1950.

Bukowska B, Woźniak E, Sicińska P, Mokra K, Michałowicz J. Glyphosate disturbs various epigenetic processes in vitro and in vivo - A mini review. Active Serial. 2022 Dec; 851(Pt 2):158259. doi: 10.1016/j.scitotenv.2022.158259.

Schaap TP, Knight M, Zwart JJ, Kurinczuk JJ, Brocklehurst P, van Roosmalen J, et al. Eclampsia, a comparison within the International Network of Obstetric Survey Systems. British journal of obstetrics and gynaecology. 2014 Nov;121(12):1521-8. doi: 10.1111/1471-0528.12712.

Coppage KH and Polzin WJ. Severe preeclampsia and delivery outcomes: is immediate cesarean delivery beneficial? American Journal of Obstetrics and Gynecology. 2002 May; 186(5):921-3. doi: 10.1067/mob.2002.124041.

Reyes LM, García RG, Ruiz SL, Camacho PA, Ospina MB, Aroca G, et al. Risk factors for preeclampsia in women from Colombia: a case-control study. PLoS One. 2012;7(7): e41622. doi: 10.1371/journal.pone.0041622.

Burton GJ, Redman CW, Roberts JM, Moffett A. Pre-eclampsia: pathophysiology and clinical implications. British Medical Journal. 2019 Jul; 366: l2381. doi: 10.1136/bmj. l2381.

Mayrink J, Souza RT, Feitosa FE, Rocha Filho EA, Leite DF, Vettorazzi J, et al. Preterm SAMBA study group. Incidence and risk factors for Preeclampsia in a cohort of healthy nulliparous pregnant women: a nested case-control study. Scientific reports. 2019 Jul; 9(1):9517. doi: 10.1038/s41598-019-46011-3.

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Published

2022-10-31
CITATION
DOI: 10.54393/pjhs.v3i05.202
Published: 2022-10-31

How to Cite

Bano, E. ., Mahar, T. ., Malhi, P. ., Hashmi , S., Soomro, A. ., & Khoso, S. . (2022). Risk Factors of Eclampsia and Its Maternal and Perinatal Effects at A Tertiary Hospital: A Retrospective Study: Risk Factors of Eclampsia and Its Maternal Effects at A Tertiary Hospital. Pakistan Journal of Health Sciences, 3(05), 194–198. https://doi.org/10.54393/pjhs.v3i05.202

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