Clinical Effectiveness of Benzoyl Peroxide and Clindamycin Combination Therapy in the Treatment of Papulopustular Acne: Combination Therapy for Papulopustular Acne

Saira Niazi; Aneela Gillani; Majid Ali Hingoro; Sadia Majeed; Sommiya Anum; Zahida Perveen

doi:10.54393/pjhs.v5i06.1790

Authors

Saira Niazi Department of Dermatology, Niazi Welfare Foundation Teaching Hospital, Sargodha, Pakistan
Aneela Gillani Department of Dermatology, Niazi Welfare Foundation Teaching Hospital, Sargodha, Pakistan
Majid Ali Hingoro Department of Pharmacology, Mohi-ud-Din Islamic Medical College, Mirpur, Pakistan
Sadia Majeed Department of Pharmacology, Continental Medical College, Lahore, Pakistan
Sommiya Anum Department of Dermatology, District Headquarter Hospital, Nankana Sahib, Pakistan
Zahida Perveen Department of Dermatology, Pak Red Crescent Medical and Dental College, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i06.1790

Keywords:

Benzoyl Peroxide, Clindamycin, Quality of Life, Papulopustular Acne, Scale of Acne Severity

Abstract

Acne is a prevalent inflammatory skin condition affecting 9% of the global population. Its impact on quality of life and self-esteem leads to depression and anxiety. Combination regimen may be effective in treating acne. Objective: To assess the clinical effectiveness of a fixed-dose combination of 1% clindamycin and 5% benzoyl peroxide in the treatment of mild to moderate papulopustular acne. Methods: An observational prospective study was conducted from June 2023 to December 2023 in the dermatology department of Niazi Welfare Foundation Teaching Hospital, Sargodha. 72 patients with mild to moderate papulopustular acne were monitored. A gel containing a combination of 1% clindamycin and 5% benzoyl peroxide was applied once daily for 12 weeks. Descriptive statistics was used for demographic variables. Chi-square test was used to evaluate the treatment effects at a significance level, p-value<0.05. Adverse effects related to therapy were shown as bar chart. Results: Findings of the study showed that during therapy in the period between the 3rd and 6th weeks, the proportion of patients who achieved excellent improvement increased by 25% from 40/72 (55.5%) to 57/72 (79.1%) respectively p < 0.05. Conclusions: The study concluded that the combination of 1% clindamycin and 5% benzoyl peroxide was effective in treating mild to moderate papulopustular acne.

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