Zinc Deficiency in Type II Diabetes Mellitus: Zinc Deficiency and Diabetes

Muhammad Faisal Javaid; Saima Rasheed; Rafiq Ahmad Siddiqui; Bilal Habib; Erum Rashid Chaudhry; Anam Abdul Rashid

doi:10.54393/pjhs.v5i05.1629

Authors

Muhammad Faisal Javaid Department of Biochemistry, Niazi Medical and Dental College, Sargodha, Pakistan
Saima Rasheed Department of Biochemistry, Watim Medical and Dental College, Rawalpindi, Pakistan
Rafiq Ahmad Siddiqui Department of Biochemistry, Services Institute of Medical Sciences, Lahore, Pakistan
Bilal Habib Department of Physiology, Rai Medical College, Sargodha, Pakistan
Erum Rashid Chaudhry Department of Biochemistry, Watim Medical and Dental College, Rawalpindi, Pakistan
Anam Abdul Rashid Department of Physiology, Niazi Medical and Dental College, Sargodha, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i05.1629

Keywords:

Zinc, Diabetes Mellitus, Trace Elements, Glycemic Control, Hyperglycemia

Abstract

Zinc (Zn) is an essential trace element for various biochemical, physiological and immunological functions in the human body. Zn deficiency affects up to 25% of the population in poor countries and up to 15% in industrialized countries. Diabetes Mellitus (DM) refers to impaired glucose metabolism, which leads to a constellation of disorders and is marked by poor immunity in the diseased subject. Zn deficiency has an inverse relationship with glycemic control. Objective: To assess the serum Zn level in diabetic patients in comparison with healthy subjects. Method: A cross sectional study was conducted at Department of Biochemistry, Niazi Welfare Foundation Teaching Hospital, Sargodha, Pakistan from 1^st June, 2023 to 31^st December, 2023. Data were collected after institutional review board (IRB) approval (NM&DC-IRB-53; Dated 1^st Dec, 2022) and informed consent was taken from all the participants. A total of 150 participants were equally divided into two groups based on glycemic control. Serum Zn levels of all participants were estimated via atomic absorption spectrophotometry. Descriptive statistic was used to calculate mean and standard deviation on SPSS version 23.0. Results: The mean value of serum Zn level was significantly lower (8.83 ± 1.64 µmol/L) in diabetic subjects as compared to healthy participants (18.63 ± 6.13 µmol/L). Conclusions: Deficiency of serum Zn level has a negative relationship with the body’s glycemic control.

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