Comparative Effects of Preoperative Carbohydrate Loading And Fasting on Recovery Outcomes in Colorectal Surgery

Carbohydrate Loading and Fasting in Colorectal Surgery

Authors

  • Ayesha Mureed Department of General Surgery, Benazir Bhutto Hospital, Rawalpindi, Pakistan
  • Asifa Dian Department of General Surgery, Benazir Bhutto Hospital, Rawalpindi, Pakistan
  • Umer Shafique Department of Orthopedics, Benazir Bhutto Hospital, Rawalpindi, Pakistan
  • Kanwal Zia Department of Pediatric Surgery, Kahuta Research Laboratories Hospital, Islamabad, Pakistan
  • Zeeshan Ahmad Department of General Surgery, Rai Medical College, Sargodha, Pakistan
  • Abdul Sattar Department of Emergency Medicine, Mukhtar A Shaikh Hospital, Multan, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i08.1579

Keywords:

Carbohydrate Loading, Colorectal Surgery, Stress Response, Insulin Resistance

Abstract

Preoperative oral carbohydrate treatment improves postoperative recovery. Fasting before surgery increases stress response and insulin resistance. Objective: To examine the effects of preoperative oral carbohydrate loading and traditional fasting on gastrointestinal function, independent walking time, and hospital stay after colorectal surgery. Methods: A quasi-experiment study with 90 individuals diagnosed by extensive history, clinical examination, and pertinent investigations split patients into Group A and Group B. General Anesthesia was used for all surgeries. Group A had surgery after 6 hours of nil per os, whereas Group B had a clear carbohydrate drink 14 hours before surgery and another 2 hours before anesthesia induction. Up to 72 hours after surgery, bowel noises, first flatus and feces, and time to independent ambulation were monitored. Results: The conventional approach in Group A produced a mean time of 51.4 ± 5.2 hours for bowel sounds, 62.9 ± 6.5 hours for first flatus, 77.95 ± 1.00 hours for defecation, 82.73 ± 9.6 hours for independent ambulation, and 5.02 ± 1.4 days for hospital stay. Group B, who received oral carbohydrate loading therapy before surgery, had shorter times for bowel sounds (43.5 ± 9.1 hours), first flatus (54.8 ± 4.6 hours), defecation (67.5 ± 11 hours), and independent ambulation (72.7 ± 6.6 hours), but a similar hospital stay (5.02 ± 1.49 days Hospital stay was not substantially different (p-value = 0.744), but surgical results were (0.000). Conclusions: Oral carbohydrate loading before colorectal surgery improves gastrointestinal function, speeds independent walking, and reduces hospital stays.

References

Helminen H, Branders H, Ohtonen P, Saarnio J. Effect of pre-operative oral carbohydrate loading on recovery after day-case cholecystectomy: a randomised controlled trial. European Journal of Anaesthesiology. 2019 Aug; 36(8): 605-11. doi: 10.1097/EJA.0000000000001002. DOI: https://doi.org/10.1097/EJA.0000000000001002

Lin MW, Chen CI, Cheng TT, Huang CC, Tsai JW, Feng GM et al. Prolonged preoperative fasting induces postoperative insulin resistance by ER-stress mediated Glut4 down-regulation in skeletal muscles. International Journal of Medical Sciences. 2021 Jan; 18(5): 1189. doi: 10.7150/ijms.52701. DOI: https://doi.org/10.7150/ijms.52701

Hatting M, Tavares CD, Sharabi K, Rines AK, Puigserver P. Insulin regulation of gluconeogenesis. Annals of the New York Academy of Sciences. 2018 Jan; 1411(1): 21-35. doi: 10.1111/nyas.13435. DOI: https://doi.org/10.1111/nyas.13435

Sarin A, Chen LL, Wick EC. Enhanced recovery after surgery-preoperative fasting and glucose loading-a review. Journal of Surgical Oncology. 2017 Oct; 116(5): 578-82. doi: 10.1002/jso.24810. DOI: https://doi.org/10.1002/jso.24810

Mathur S, Plank LD, McCall JL, Shapkov P, McIlroy K, Gillanders LK et al. Randomized controlled trial of preoperative oral carbohydrate treatment in major abdominal surgery. Journal of British Surgery. 2010 Apr; 97(4): 485-94. doi: 10.1002/bjs.7026. DOI: https://doi.org/10.1002/bjs.7026

Kotfis K, Jamioł-Milc D, Skonieczna-Żydecka K, Folwarski M, Stachowska E. The effect of preoperative carbohydrate loading on clinical and biochemical outcomes after cardiac surgery: A systematic review and meta-analysis of randomized trials. Nutrients. 2020 Oct; 12(10): 3105. doi: 10.3390/nu12103105. DOI: https://doi.org/10.3390/nu12103105

Liu B, Wang Y, Liu S, Zhao T, Zhao B, Jiang X et al. A randomized controlled study of preoperative oral carbohydrate loading versus fasting in patients undergoing elective craniotomy. Clinical Nutrition. 2019 Oct; 38(5): 2106-12. doi: 10.1016/j.clnu.2018.11.008. DOI: https://doi.org/10.1016/j.clnu.2018.11.008

Hedrick TL, McEvoy MD, Mythen MM, Bergamaschi R, Gupta R, Holubar SD et al. American society for enhanced recovery and perioperative quality initiative joint consensus statement on postoperative gastrointestinal dysfunction within an enhanced recovery pathway for elective colorectal surgery. Anesthesia & Analgesia. 2018 Jun; 126(6): 1896-907. doi: 10.1213/ANE.0000000000002742. DOI: https://doi.org/10.1213/ANE.0000000000002742

Hu Q, Ren J, Li G, Wu X, Wang G, Gu G et al. Clinical significance of post-operative hyperglycemia in nondiabetic patients undergoing definitive surgery for gastrointestinal fistula. Surgical Infections. 2016 Aug; 17(4): 491-7. doi: 10.1089/sur.2016.050. DOI: https://doi.org/10.1089/sur.2016.050

Talutis SD, Lee SY, Cheng D, Rosenkranz P, Alexanian SM, McAneny D. The impact of preoperative carbohydrate loading on patients with type II diabetes in an enhanced recovery after surgery protocol. The American Journal of Surgery. 2020 Oct; 220(4): 999-1003. doi: 10.1016/j.amjsurg.2020.03.032. DOI: https://doi.org/10.1016/j.amjsurg.2020.03.032

Cua S, Humeidan M, Beal EW, Brethauer S, Pervo V, Papio J et al. The effect of an enhanced recovery protocol on colorectal surgery patients with diabetes. Journal of Surgical Research. 2021 Jan; 257: 153-60. doi: 10.1016/j.jss.2020.07.041. DOI: https://doi.org/10.1016/j.jss.2020.07.041

Gianotti L, Biffi R, Sandini M, Marrelli D, Vignali A, Caccialanza R, Viganò J, Sabbatini A, Di Mare G, Alessiani M, Antomarchi F, Valsecchi MG, Bernasconi DP. Preoperative oral carbohydrate load versus placebo in major elective abdominal surgery (PROCY): a randomized, placebo-controlled, multicenter, phase III trial. Annals of Surgery. 2018 Apr; 267(4): 623-630. doi: 10.1097/SLA.0000000000002325. DOI: https://doi.org/10.1097/SLA.0000000000002325

Sada F, Krasniqi A, Hamza A, Gecaj-Gashi A, Bicaj B, Kavaja F. A randomized trial of preoperative oral carbohydrates in abdominal surgery. BioMed Central Anesthesiology. 2014 Dec; 14: 1-7. doi: 10.1186/1471-2253-14-93. DOI: https://doi.org/10.1186/1471-2253-14-93

Amer MA, Smith MD, Herbison GP, Plank LD, McCall JL. Network meta-analysis of the effect of preoperative carbohydrate loading on recovery after elective surgery. Journal of British Surgery. 2017 Feb; 104(3): 187-97. doi: 10.1002/bjs.10408. DOI: https://doi.org/10.1002/bjs.10408

Martínez-Ortega AJ, Piñar-Gutiérrez A, Serrano-Aguayo P, González-Navarro I, Remón-Ruíz PJ, Pereira-Cunill JL et al. Perioperative nutritional support: a review of current literature. Nutrients. 2022 Apr; 14(8): 1601. doi: 10.3390/nu14081601. DOI: https://doi.org/10.3390/nu14081601

Amirshahi M, Behnamfar N, Badakhsh M, Rafiemanesh H, Keikhaie KR, Sheyback M et al. Prevalence of postoperative nausea and vomiting: A systematic review and meta-analysis. Saudi journal of anaesthesia. 2020 Jan; 14(1): 48-56. doi: 10.4103/sja.SJA_401_19. DOI: https://doi.org/10.4103/sja.SJA_401_19

Ueland W, Walsh-Blackmore S, Nisiewicz M, Davenport DL, Plymale MA, Plymale M et al. The contribution of specific enhanced recovery after surgery (ERAS) protocol elements to reduced length of hospital stay after ventral hernia repair. Surgical Endoscopy. 2020 Oct; 34: 4638-44. doi: 10.1007/s00464-019-07233-8. DOI: https://doi.org/10.1007/s00464-019-07233-8

van der Geest LG, Lemmens VE, de Hingh IH, van Laarhoven CJ, Bollen TL, Nio CY et al. Nationwide outcomes in patients undergoing surgical exploration without resection for pancreatic cancer. Journal of British Surgery. 2017 Oct; 104(11): 1568-77. doi: 10.1002/bjs.10602. DOI: https://doi.org/10.1002/bjs.10602

Rizvanović N, Nesek Adam V, Čaušević S, Dervišević S, Delibegović S. A randomised controlled study of preoperative oral carbohydrate loading versus fasting in patients undergoing colorectal surgery. International Journal of Colorectal Disease. 2019 Sep; 34: 1551-61. doi: 10.1007/s00384-019-03349-4. DOI: https://doi.org/10.1007/s00384-019-03349-4

Duverseau MO, O'Neill AM, Sulzer JK, Darden M, Parker G, Buell JF. Comparison of surgical outcomes for colostomy closure performed by acute care surgeons versus a dedicated colorectal surgery service. Surgery. 2022 Mar; 171(3): 635-40. doi: 10.1016/j.surg.2021.10.026. DOI: https://doi.org/10.1016/j.surg.2021.10.026

Qin PP, Jin JY, Min S, Wang WJ, Shen YW. Association between health literacy and enhanced recovery after surgery protocol adherence and postoperative outcomes among patients undergoing colorectal cancer surgery: a prospective cohort study. Anesthesia & Analgesia. 2022 Feb; 134(2): 330-40. doi: 10.1213/ANE.0000000000005829. DOI: https://doi.org/10.1213/ANE.0000000000005829

Stenberg E, dos Reis Falcao LF, O'Kane M, Liem R, Pournaras DJ, Salminen P et al. Guidelines for perioperative care in bariatric surgery: enhanced recovery after surgery (ERAS) society recommendations: a 2021 update. World Journal of Surgery. 2022 Apr; 46(4): 729-51. doi: 10.1007/s00268-021-06394-9. DOI: https://doi.org/10.1007/s00268-021-06394-9

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Published

2024-08-31
CITATION
DOI: 10.54393/pjhs.v5i08.1579
Published: 2024-08-31

How to Cite

Mureed, A., Dian, A., Shafique, U., Zia, K., Ahmad, Z., & Sattar, A. (2024). Comparative Effects of Preoperative Carbohydrate Loading And Fasting on Recovery Outcomes in Colorectal Surgery: Carbohydrate Loading and Fasting in Colorectal Surgery. Pakistan Journal of Health Sciences, 5(08), 66–70. https://doi.org/10.54393/pjhs.v5i08.1579

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