Frequency of Dry Eye in Migraine Patients: Frequency of Dry Eye

Dua Asif; Samah Zahid Ali Shah; Tabinda Shahid; Aima Pervaiz; Rimsha Batool; Ambreen Ziarat; Hira Anwar

doi:10.54393/pjhs.v4i12.1117

Authors

Dua Asif Department of Optometry and Vision Sciences, The University of Lahore, Lahore, Pakistan
Samah Zahid Ali Shah Department of Optometry and Vision Sciences, The University of Lahore, Lahore, Pakistan
Tabinda Shahid Department of Optometry and Vision Sciences, The University of Lahore, Lahore, Pakistan
Aima Pervaiz Department of Optometry and Vision Sciences, The University of Lahore, Lahore, Pakistan
Rimsha Batool Department of Optometry and Vision Sciences, The University of Lahore, Lahore, Pakistan
Ambreen Ziarat Department of Optometry and Vision Sciences, The University of Lahore, Lahore, Pakistan
Hira Anwar Department of Optometry and Vision Sciences, The University of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v4i12.1117

Keywords:

Dry Eye, Migraine, Schirmer Test

Abstract

Dry eye disease and migraine are prevalent conditions in the general population. While there is evidence of symptoms overlapping, few studies have quantified the occurrence of dry eye in migraine patients. The study was conducted to find the frequency of dry eye syndrome among individuals with migraines. Objective: To evaluate the “frequency of dry eye disease in migraine patients”. Methods: This descriptive cross-sectional study included 217 clinically diagnosed migraine patients between the ages of 18 to 29 at the University of Lahore Teaching Hospital. The study took place over four months, from February 2023 to May 2023. Dry Eye Disease was assessed using the dry eye symptoms questionnaire (Speed II Questionnaire) and Schirmer test 1 as the primary diagnostic tool. Results: The analysis included calculating descriptive statistics (percentages and means) and presenting results in tables and figures for clarity and understanding. Out of 217 migrainous patients, 38.2% of participants had normal eyes. Among the rest, 17.1% showed Mild, 2.3% Moderate dry eye. The Schirmer Test showed that 41.9% had suffered from severe dry eye. Overall, the study showed that 133 patients (61%) suffered from dry eye. Conclusions: The study's conclusion highlighted a notable rise in dry eye disease among migraine patients, in line with previous research. This underscores the need for further exploration into the underlying mechanisms and therapeutic interventions for individuals dealing with both conditions.

References

Dogru M, Nakamura M, Shimazaki J, Tsubota K. Changing trends in the treatment of Dry Eye Disease. Expert Opinion on Investigational Drugs. 2013 Dec; 22 (12): 1581-601. doi: 10.1517/13543784.2013.838557. DOI: https://doi.org/10.1517/13543784.2013.838557

Aragona P, Giannaccare G, Mencucci R, Rubino P, Cantera E, Rolando M. Modern approach to the treatment of dry eye, a complex multifactorial disease: a PICASSO board review. British Journal of Ophthalmology. 2021 Apr; 105(4): 446-53. doi: 10.1136/bjophthalmol-2019-315747. DOI: https://doi.org/10.1136/bjophthalmol-2019-315747

Papas EB. The global prevalence of dry eye disease. A Bayesian view. Ophthalmic and Physiological Optics. 2021 Nov; 41(6): 1254-1266. doi: 10.1111/opo.12888. DOI: https://doi.org/10.1111/opo.12888

Wei Y, and Asbell PA. The Core Mechanism of Dry Eye Disease (DED) Is Inflammation. National Institute of Health. 2014 Jul; 40(6): 248-56. doi: 10.1097/ICL.0000000000000042. DOI: https://doi.org/10.1097/ICL.0000000000000042

Rolando M and Zierhut M. The Ocular Surface and Tear Film and Their Dysfunction in Dry Eye Disease. Survey of Ophthalmology. 2001 Mar; 45:S 203–10. doi: 10.1016/S0039-6257(00)00203-4. DOI: https://doi.org/10.1016/S0039-6257(00)00203-4

Chang AY and Purt B. Biochemistry, tear film. StatPearls Publishing, Treasure Island (FL); 2021

Cwiklik L. Tear film lipid layer: A molecular level view. Biochimica et Biophysica Acta (BBA)-Biomembranes. 2016 Oct ; 1858(10): 2421-30. doi: 10.1016/j.bbamem.2016.02.020. DOI: https://doi.org/10.1016/j.bbamem.2016.02.020

Rahman M, Okamoto K, Thompson R, Katagiri A, Bereiter DA. Sensitization of trigeminal brainstem pathways in a model for tear deficient dry eye. Pain. 2015 May; 156(5): 942. doi: 10.1097/j.pain.0000000000000135. DOI: https://doi.org/10.1097/j.pain.0000000000000135

Javadi M and Feizi S. Dry Eye Syndrome. Journal of Ophthalmic and Vision Research. 2011 July; 6(3): 192-198

Bartlett JD, Keith MS, Sudharshan L, Snedecor SJ. Associations between signs and symptoms of dry eye disease: a systematic review. Clinical Ophthalmology. 2015 Sep; 9:1719-30. doi: 10.2147/OPTH.S89700. DOI: https://doi.org/10.2147/OPTH.S89700

Achtsidis V, Kozanidou E, Bournas P, Tentolouris N, Theodossiadis PG. Dry eye and clinical disease of tear film, diagnosis and management, European Ophthalmic Review. 2014 May; 8(1): 17-22. doi: 10.17925/EOR.2014.08.01.17. DOI: https://doi.org/10.17925/EOR.2014.08.01.17

Steven S. Schirmer’s test. Community Eye Health 2011 Dec; 24(76): 45.

Lin H and Yiu SC. Dry eye disease: A review of diagnostic approaches and treatments. Saudi Journal of Ophthalmology. 2014 Jul; 28(3): 173-81. doi: 10.1016/j.sjopt.2014.06.002. DOI: https://doi.org/10.1016/j.sjopt.2014.06.002

Ashina M, Hansen JM, Do TP, Melo-Carrillo A, Burstein R, Moskowitz MA. Migraine and the trigeminovascular system—40 years and counting. The Lancet Neurology. 2019 Aug; 18(8): 795-804. doi: 10.1016/S1474-4422(19)30185-1. DOI: https://doi.org/10.1016/S1474-4422(19)30185-1

Shetty R, Deshpande K, Jayadev C, Wadia K, Mehta P, Shroff R et al. The impact of dysfunctional tear films and optical aberrations on chronic migraine. Eye and Vision. 2017 Dec; 4(1):1-4. doi: 10.1186/s40662-017-0070-1. DOI: https://doi.org/10.1186/s40662-017-0070-1

Müller B, Gaul C, Reis O, Jürgens TP, Kropp P, Ruscheweyh R et al. Headache impact and socioeconomic status: findings from a study of the German Migraine and Headache Society (DMKG). The Journal of Headache and Pain. 2023 Dec; 24(1): 1-4. doi: 10.1186/s10194-023-01564-7. DOI: https://doi.org/10.1186/s10194-023-01564-7

Messina R, Cetta I, Colombo B, Filippi M. Tracking the evolution of non-headache symptoms through the migraine attack. The Journal of Headache and Pain. 2022 Dec; 23(1): 1-9. doi: 10.1186/s10194-022-01525-6. DOI: https://doi.org/10.1186/s10194-022-01525-6

Chen H, Chen A, Wang S, Zou M, Young CA, Zheng D et al. Association Between Migraine and Dry Eye: A Systematic Review and Metaanalysis. Cornea. 2022 Jun; 41(6): 740-5. doi: 10.1097/ICO.0000000000002851. DOI: https://doi.org/10.1097/ICO.0000000000002851

Latremoliere A and Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. The Journal of Pain. 2009 Sep; 10(9): 895-926. doi: 10.1016/j.jpain.2009.06.012. DOI: https://doi.org/10.1016/j.jpain.2009.06.012

Rea BJ, Wattiez AS, Waite JS, Castonguay WC, Schmidt CM, Fairbanks AM et al. Peripherally administered CGRP induces spontaneous pain in mice: Implications for migraine. Pain. 2018 Nov; 159(11): 2306. doi: 10.1097/j.pain.0000000000001337. DOI: https://doi.org/10.1097/j.pain.0000000000001337

Crane AM, Feuer W, Felix ER, Levitt RC, McClellan AL, Sarantopoulos KD et al. Evidence of central sensitisation in those with dry eye symptoms and neuropathic-like ocular pain complaints: incomplete response to topical anaesthesia and generalised heightened sensitivity to evoked pain. British Journal of Ophthalmology. 2017 Sep; 101(9): 1238-43. doi: 10.1136/bjophthalmol-2016-309658. DOI: https://doi.org/10.1136/bjophthalmol-2016-309658

Baksh BS, Garcia JC, Galor A. Exploring the link between dry eye and migraine: from eye to brain. Eye and Brain. 2021 Mar; 13: 41-57. doi: 10.2147/EB.S234073. DOI: https://doi.org/10.2147/EB.S234073

Ismail OM, Poole ZB, Bierly SL, Van Buren ED, Lin FC, Meyer JJ et al. Association between dry eye disease and migraine headaches in a large population-based study. JAMA Ophthalmology. 2019 May; 137(5): 532-6. doi: 10.1001/jamaophthalmol.2019.0170. DOI: https://doi.org/10.1001/jamaophthalmol.2019.0170

Farhangi M, Diel RJ, Buse DC, Huang AM, Levitt RC, Sarantopoulos CD et al. Individuals with migraine have a different dry eye symptom profile than individuals without migraine. British Journal of Ophthalmology. 2020 Feb; 104(2): 260-4. doi: 10.1136/bjophthalmol-2018-313471. DOI: https://doi.org/10.1136/bjophthalmol-2018-313471

Yang S, Kim W, Kim HS, Na KS, Epidemiologic Survey Committee of the Korean Ophthalmologic Society. Association between migraine and dry eye disease: a nationwide population-based study. Current Eye Research. 2017 Jun; 42(6): 837-41. doi: 10.1080/02713683.2016.1262876. DOI: https://doi.org/10.1080/02713683.2016.1262876

Sarac O, Kosekahya P, Yildiz Tasci Y, Keklikoglu HD, Deniz O, Erten Ş et al. The Prevalence of Dry Eye and Sjögren Syndrome in Patients with Migraine. Ocular Immunology and Inflammation. 2016 Feb; 25(3): 370–5. doi: 10.3109/09273948.2015.1132739. DOI: https://doi.org/10.3109/09273948.2015.1132739