Evaluation of haematological variables in patients with typhoid in Pakistan

Hematological Parameters in Patients with Typhoid

Authors

  • Syed Kashif Raza Faculty of Rehabilitation and Allied Health Sciences (FRAHS), Riphah International University, Faisalabad, Pakistan
  • Hina Javaid College of Allied Health Sciences, Medical Directorate, Government College University Faisalabad, Pakistan
  • Hassan Bajwa Faculty of Rehabilitation and Allied Health Sciences (FRAHS), Riphah International University, Faisalabad, Pakistan
  • Kamran Saleem Faculty of Rehabilitation and Allied Health Sciences (FRAHS), Riphah International University, Faisalabad, Pakistan
  • Muhammad Hashim Faculty of Rehabilitation and Allied Health Sciences (FRAHS), Riphah International University, Faisalabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v3i06.104

Keywords:

Typhoid, Leukocytosis, Thrombocytopenia, NLCR, Haematological Factors

Abstract

Typhoid fever results in significant hepatic problems and biochemical abnormalities. The most effective diagnostic procedure now is the bacterial culture, but serologic tests are still often used, and a speedy and accurate diagnostic test for typhoid fever is still required. Objectives: To examine the haematological parameters between typhoid patients and healthy individuals to find any distinctive parameters that could be used as typhoid fever diagnostic indicators. Methods: This study set out to compare haematological changes in 550 patients with 550 healthy persons. Results: We found low hemoglobin (8.95±1.43), low hematocrit (32.62±5.38), high ESR (53.89±9.21), high platelet count (482003±86792), high WBCs count (14464±1694), high neutrophil percentage (63.60±9.26), low lymphocyte percentage (25.33±2.93), and high NLCR (2.498±0.45) against the healthy control group. Conclusions: This distinctive pattern can be easily obtained using a minimally invasive method and used to diagnose typhoid fever.

 

References

Yasin N, Jabeen A, Nisa I, Tasleem U, Khan H, Momin F, et al. A review: Typhoid fever. Journal of Bacteriology and Infectious Diseases. 2018; 2(2):1-7.

Willke A, Ergonul O, Bayar B. Widal test in diagnosis of typhoid fever in Turkey. Clinical and Vaccine Immunology. 2002 Jul; 9(4):938-41. doi.org/10.1128/CDLI.9.4.938-941.2002.

Kalayci C, Karacadag S, Kansu E. Typhoid fever—a report of 90 cases. Infeksiyon Dergisi. 1987;3:89-91.

Olsen SJ, Pruckler J, Bibb W, Thanh NT, Trinh TM, Minh NT, et al. Evaluation of rapid diagnostic tests for typhoid fever. Journal of clinical microbiology. 2004 May; 42(5):1885-9. doi: 10.1128/JCM.42.5.1885-1889.2004

Rowe B, Ward LR, Threlfall EJ. Multidrug-resistant Salmonella typhi: a worldwide epidemic. Clinical infectious diseases. 1997 Jan; 24(1):S106-9. doi.org/10.1093/clinids/24.Supplement_1.S106

Buckle GC, Walker CLF, Black RE. Typhoid fever and paratyphoid fever: Systematic review to estimate global morbidity and mortality for 2010. Journal of global health. 2012; 2(1).

Luby SP, Faizan MK, Fisher-Hoch SP, Syed A, Mintz ED, Bhutta ZA, et al. Risk factors for typhoid fever in an endemic setting, Karachi, Pakistan. Epidemiology & Infection. 1998 Mar; 120(2):129-38. doi.org/10.1017/S0950268897008558

Olopoenia LA, King AL. Widal agglutination test− 100 years later: still plagued by controversy. Postgraduate medical journal. 2000 Feb; 76(892):80-4. doi.org/10.1136/pmj.76.892.80

Ifeanyi OE. Changes in some haematological parameters in typhoid patients attending University Health Services Department of Michael Okpara University of Agriculture, Nigeria. Int. J. Curr. Microbiol. App. Sci. 2014; 3(1):670-4.

Bhutta ZA. Current concepts in the diagnosis and treatment of typhoid fever. Bmj. 2006 Jul; 333(7558):78-82. doi.org/10.1136/bmj.333.7558.78

Yadav K, Yadav SK, Parihar G. A comparative study of typhidot and widal test for rapid diagnosis of typhoid fever. International journal of current microbiology and applied sciences. 2015; 4(5):34-8.

Mathai E, John TJ, Rani M, Mathai D, Chacko N, Nath V, et al. Significance of Salmonella typhi bacteriuria. Journal of Clinical Microbiology. 1995 Jul;33(7):1791-2. doi.org/10.1128/jcm.33.7.1791-1792.1995

Pearson RD, Guerrant RL. Enteric fever and other causes of abdominal symptoms with fever. Principles and practice of infectious diseases, 5th ed. Churchill Livingstone, New York, NY. 2000:1136-50.

Siddiqui FJ, Rabbani F, Hasan R, Nizami SQ, Bhutta ZA. Typhoid fever in children: some epidemiological considerations from Karachi, Pakistan. International Journal of Infectious Diseases. 2006 May; 10(3):215-22. doi.org/10.1016/j.ijid.2005.03.010

Raza SK, Saleem M, Shamsi T, Choudhary MI, Musharraf SG. 5D proteomic approach for the biomarker search in plasma: Acute myeloid leukaemia as a case study. Scientific reports. 2017 Nov; 7(1):1-2. doi:10.1038/s41598-017-16699-2

Saleem M, Raza SK, G Musharraf S. A comparative protein analysis of lung cancer, along with three controls using a multidimensional proteomic approach. Experimental Biology and Medicine. 2019 Jan;244(1):36-41. doi.org/10.1177/1535370219826

Parry CM. Epidemiological and clinical aspects of human typhoid fever. Salmonella infections: clinical, immunological and molecular aspects.. 2006:1-24.

Chowdhury F, Chisti MJ, Khan AH, Chowdhury MA, Pietroni MA. Salmonella typhi and Plasmodium falciparum co-infection in a 12-year old girl with haemoglobin E trait from a non-malarious area in Bangladesh. Journal of health, population, and nutrition. 2010 Oct; 28(5):529.

Chaicumpa W, Thin-Inta WU, Khusmith SR, Tapchaisri PR, Echeverria P, Kalambaheti TH, et al. Detection with monoclonal antibody of Salmonella typhi antigen 9 in specimens from patients. Journal of Clinical Microbiology. 1988 Sep; 26(9):1824-30. doi.org/10.1128/jcm.26.9.1824-1830.1988

Abraham G, Teklu B, Gedebu M, Selassie GH, Azene G. Diagnostic value of the Widal test. Tropical and Geographical Medicine. 1981 Dec; 33(4):329-33.

Adams NG. Diagnostic use of C‐reactive protein in bacteraemic emergency department patients. Emergency Medicine Australasia. 2005 Aug; 17(4):371-5. doi.org/10.1111/j.1742-6723.2005.00759.x

de Jager CP, Wever PC, Gemen EF, Kusters R, van Gageldonk-Lafeber AB, van der Poll T, et al. The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia. doi.org/10.1371/journal.pone.0046561

Eissa EA, El-Sayed TI, Attia AA, Rashed ME, Refaat HM. Proinflammatory cytokines in plasma of patients with typhoid fever and resistance to therapy. Egyptian Journal of Microbiology. 2018 Dec; 53(1):141-9. doi: 10.21608/ejm.2018.3992.1061

Oh EM, Sim JH, Hwang JH, Yim HE, Kim YK. A Case of Childhood Typhoid Fever Complicated with Acute Nephritis. Pediatric Infection & Vaccine. 2015 Apr; 22(1):36-9. doi.org/10.14776/piv.2015.22.1.36

Villablanca P, Mohananey D, Meier G, Yap JE, Chouksey S, Abegunde AT. Salmonella Berta myocarditis: Case report and systematic review of non-typhoid Salmonella myocarditis. World Journal of Cardiology. 2015 Dec; 7(12):931. doi: 10.4330/wjc.v7.i12.931

Wen Z, HE Y, FU D. Clinical analysis of typhoid fever complicated with hemophagocytic syndrome in one case. Journal of Clinical Pediatrics. 2016:737-9.

Wyllie DH, Bowler IC, Peto TA. Relation between lymphopenia and bacteraemia in UK adults with medical emergencies. Journal of clinical pathology. 2004 Sep; 57(9):950-5. doi.org/10.1136/jcp.2004.017335

Wyllie DH, Bowler IC, Peto TE. Bacteraemia prediction in emergency medical admissions: role of C reactive protein. Journal of clinical pathology. 2005 Apr; 58(4):352-6. doi.org/10.1136/jcp.2004.022293

de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Critical care. 2010 Oct; 14(5):1-8.

Joshi VD, Kalvakolanu DV, Cross AS. Simultaneous activation of apoptosis and inflammation in pathogenesis of septic shock: a hypothesis. FEBS letters. 2003 Dec; 555(2):180-4. doi.org/10.1016/S0014-5793(03)01271-7

Le Tulzo Y, Pangault C, Gacouin A, Guilloux V, Tribut O, Amiot L, et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock. 2002 Dec; 18(6):487-94.

Ayala A, Herdon CD, Lehman DL, Ayala CA, Chaudry IH. Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators. doi.org/10.1182/blood.V87.10.4261.bloodjournal87104261

Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Critical care medicine. 1999 Jul; 27(7):1230-51.

Ommen SR, Hodge DO, Rodeheffer RJ, McGregor CG, Thomson SP, Gibbons RJ. Predictive power of the relative lymphocyte concentration in patients with advanced heart failure. Circulation. 1998 Jan; 97(1):19-22. doi.org/10.1161/01.CIR.97.1.19

Acanfora D, Gheorghiade M, Trojano L, Furgi G, Pasini E, Picone C, et al. CHF Italian Study Investigators. Relative lymphocyte count: a prognostic indicator of mortality in elderly patients with congestive heart failure. American heart journal. 2001 Jul; 142(1):167-73. doi.org/10.1067/mhj.2001.115792

Huehnergarth KV, Mozaffarian D, Sullivan MD, Crane BA, Wilkinson CW, Lawler RL, et al. Usefulness of relative lymphocyte count as an independent predictor of death/urgent transplant in heart failure. The American journal of cardiology. 2005 Jun; 95(12):1492-5. doi.org/10.1016/j.amjcard.2005.02.022

Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. American heart journal. 2007 Nov; 154(5):995-1002. doi.org/10.1016/j.ahj.2007.06.043

Sarraf KM, Belcher E, Raevsky E, Nicholson AG, Goldstraw P, Lim E. Neutrophil/lymphocyte ratio and its association with survival after complete resection in non–small cell lung cancer. The Journal of thoracic and cardiovascular surgery. 2009 Feb; 137(2):425-8. doi.org/10.1016/j.jtcvs.2008.05.046

Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. The American journal of cardiology. 2008 Sep; 102(6):653-7. doi.org/10.1016/j.amjcard.2008.05.006

Fraker PJ, Lill-Elghanian DA. The many roles of apoptosis in immunity as modified by aging and nutritional status. The journal of nutrition, health & aging. 2004 Jan; 8(1):56-63.

Fock RA, Blatt SL, Beutler B, Pereira J, Tsujita M, de Barros FE, et al. Study of lymphocyte subpopulations in bone marrow in a model of protein–energy malnutrition. Nutrition. 2010 Oct; 26(10):1021-8. doi.org/10.1016/j.nut.2009.08.026

Weinstein MP. Current blood culture methods and systems: clinical concepts, technology, and interpretation of results. Clinical infectious diseases. 1996 Jul; 23(1):40-6. doi.org/10.1093/clinids/23.1.40

Downloads

Published

2022-11-30
CITATION
DOI: 10.54393/pjhs.v3i06.104
Published: 2022-11-30

How to Cite

Kashif Raza, S. . ., Javaid , H. ., Bajwa , H. ., Saleem, K. ., & Hashim, M. . (2022). Evaluation of haematological variables in patients with typhoid in Pakistan: Hematological Parameters in Patients with Typhoid. Pakistan Journal of Health Sciences, 3(06), 73–77. https://doi.org/10.54393/pjhs.v3i06.104

Issue

Section

Original Article

Plaudit

Most read articles by the same author(s)