Incidental Renal Artery Stenosis amongst a Cohort of Hypertensive Patients Undergoing Coronary Angiography: An Analytical Cross-Sectional Study

Incidental Renal Artery Stenosis: Hypertensive Patients Undergoing Coronary Angiography

Authors

  • Zuhoor Ud Din Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan
  • Sheeba Ishaq Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan
  • Jahanzeb Ibrahim Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan
  • Sara Daud Khan Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan
  • Hina Gul Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan
  • Sahib Noor Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan
  • Wassay Hassan Khan Department of Internal Medicine, SUNY Upstate Medical University, New York, United State of America

DOI:

https://doi.org/10.54393/pjhs.v7i4.3763

Keywords:

Renal Artery Obstruction, Hypertension, Coronary Angiography, Incidental Renal Artery Stenosis

Abstract

There has been less research on accidental RAS in patients with hypertension who have received coronary angiography. Objectives: To determine the prevalence rate of incidental renal artery stenosis (IRAS) in patients having coronary angiography. Methods: This analytical cross-sectional study was conducted at Khyber Teaching Hospital for six months between 1st April 2025 and 30th September 2025. Consecutive sampling was used to enroll 139 hypertensive patients under diagnostic coronary angiography as participants. Findings of coronary angiography and incidental evaluation of the renal artery were recorded, with stenosis of ≥50% seen as IRAS. The analysis of data was done with SPSS version 25.0. Odds ratios were estimated at 95% confidence intervals using univariate analysis. Results: Incidental renal artery stenosis was observed in 18.0% of patients, and in 13.7% and 4.3%, respectively, bilateral and unilateral renal artery stenosis. IRAS was significantly correlated with longer hypertension period and high serum creatinine (p<0.05). Conclusions: Nearly one-fifth of hypertension patients who had coronary angiography had incidental renal artery stenosis, most of which were unilateral. Chronic hypertension and high creatinine were identified as some of the most important associated factors, and it is important to evaluate renal arteries when the coronary arteries should be evaluated to be able to assess the cardiovascular and renal risks.

Author Biographies

Zuhoor Ud Din, Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan

 

Jahanzeb Ibrahim, Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan

   

Sara Daud Khan, Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan

   

Hina Gul, Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan

     

Sahib Noor, Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan

     

References

Goorani S, Zangene S, Imig JD. Hypertension: A Continuing Public Healthcare Issue. International Journal of Molecular Sciences. 2024 Dec; 26(1): 123. doi: 10.3390/ijms26010123. DOI: https://doi.org/10.3390/ijms26010123

Liu J, Bu X, Wei L, Wang X, Lai L, Dong C et al. Global Burden of Cardiovascular Diseases Attributable to Hypertension in Young Adults from 1990 to 2019. Journal of Hypertension. 2021 Dec; 39(12): 2488-96. doi: 10.1097/HJH.0000000000002958. DOI: https://doi.org/10.1097/HJH.0000000000002958

Dobrek L. An Outline of Renal Artery Stenosis Pathophysiology—A Narrative Review. Life. 2021 Mar; 11(3): 208. doi: 10.3390/life11030208. DOI: https://doi.org/10.3390/life11030208

Arab SF, Alhumaid AA, Alnasr MT, Altuwaijri TA, Al-Ghofili H, Al-Salman MM et al. Review of Renal Artery Stenosis and Hypertension: Diagnosis, Management, and Recent Randomized Control Trials. Saudi Journal of Kidney Diseases and Transplantation. 2022 Jan; 33(1): 147-59.

Gunawardena T. Atherosclerotic Renal Artery Stenosis: A Review. Aorta. 2021 Jun; 9(03): 095-9. doi: 10.1055/s-0041-1730004. DOI: https://doi.org/10.1055/s-0041-1730004

Li Y, Chen Z, Lan R, Ran T, He J, Li J et al. Atherosclerotic Renal Artery Stenosis, Mediating Biomarkers, and Risk of Cardiac among Individuals with Hypertension: A Real-World Study. International Journal of Cardiology: Heart and Vasculature. 2024 Dec; 55: 101556. doi: 10.1016/j.ijcha.2024.101556. DOI: https://doi.org/10.1016/j.ijcha.2024.101556

Schwarz K, Straume Bah I, Will M, Kwok CS, Mascherbauer J, Kumric M et al. Prevalence and Risk Factors of Renal Artery Stenosis in Patients Undergoing Simultaneous Coronary and Renal Artery Angiography: A Systematic Review and Meta-Analysis of 31,689 Patients from 31 Studies. Diseases. 2024 Sep; 12(9): 208. doi: 10.3390/diseases12090208. DOI: https://doi.org/10.3390/diseases12090208

Li H, Liu L, Tang X, Jing K, Pan C. Association Between Inter-Arm Blood Pressure Difference and Prevalence of Renal Artery Stenosis in Patients with Ischemic Stroke. Blood Pressure Monitoring. 2025 Aug; 30(4): 175-80. doi: 10.1097/MBP.0000000000000753. DOI: https://doi.org/10.1097/MBP.0000000000000753

Triantis G, Chalikias GK, Ioannidis E, Dagre A, Tziakas DN. Renal Artery Revascularization Is a Controversial Treatment Strategy for Renal Artery Stenosis: A Case Series and A Brief Review of the Current Literature. Hellenic Journal of Cardiology. 2022 May; 65: 42-8. doi: 10.1016/j.hjc.2022.03.008. DOI: https://doi.org/10.1016/j.hjc.2022.03.008

Fay KS and Cohen DL. Resistant Hypertension in People with CKD: A Review. American Journal of Kidney Diseases. 2021 Jan; 77(1): 110-21. doi: 10.1053/j.ajkd.2020.04.017. DOI: https://doi.org/10.1053/j.ajkd.2020.04.017

Yathish BE and Mathur P. Incidence of Significant Renal Artery Stenosis in Patients Undergoing Primary PTCA. European Journal of Cardiovascular Medicine. 2025 Nov; 15: 615-9.

Lwanga SK and Lemeshow S. Sample Size Determination in Health Studies. Geneva: World Health Organization. 1991 Sep; 1.

Chrysochou C and Kalra PA. Epidemiology and Natural History of Atherosclerotic Renovascular Disease. Progress in Cardiovascular Diseases. 2009 Nov; 52(3): 184-95. doi: 10.1016/j.pcad.2009.09.001. DOI: https://doi.org/10.1016/j.pcad.2009.09.001

Weber BR and Dieter RS. Renal Artery Stenosis: Epidemiology and Treatment. International Journal of Nephrology and Renovascular Disease. 2014 May: 169-81. doi: 10.2147/IJNRD.S40175. DOI: https://doi.org/10.2147/IJNRD.S40175

Ollivier R, Boulmier D, Veillard D, Leurent G, Mock S, Bedossa M et al. Frequency and Predictors of Renal Artery Stenosis in Patients with Coronary Artery Disease. Cardiovascular Revascularization Medicine. 2009 Jan; 10(1): 23-9. doi: 10.1016/j.carrev.2008.06.003. DOI: https://doi.org/10.1016/j.carrev.2008.06.003

Ghaffari S, Sohrabi B, Siahdasht RB, Pourafkari L. Prevalence and Predictors of Renal Artery Stenosis in Hypertensive Patients Undergoing Coronary Angiography. Hypertension Research. 2009 Nov; 32(11): 1009-14. doi: 10.1038/hr.2009.149. DOI: https://doi.org/10.1038/hr.2009.149

Silva J, Tonheiro J, Rodrigues F. The “Silent Enemy” Called Renal Artery Stenosis: A Mini-Review. Journal of Vascular Diseases. 2025 Mar; 4(1): 10. doi: 10.3390/jvd4010010. DOI: https://doi.org/10.3390/jvd4010010

Shahid Y, Khalil AA, Mehmood SA, Gul H, Ullah SA, Shah AU. Association of Renal Artery Stenosis with Coronary Artery Disease in Hypertensive Patients: A Cross-Sectional Study. Journal of Khyber College of Dentistry. 2024 Mar; 14(01): 51-4. doi: 10.33279/jkcd.v14i01.694. DOI: https://doi.org/10.33279/jkcd.v14i01.694

Kumar TS, Daya KS, Adilakshmi B, Rao MS. Study of Prevalence and Predictors of Renal Artery Stenosis in Hypertensive Patients with Coronary Artery Disease Undergoing Coronary Angiography. European Journal of Cardiovascular Medicine. 2024 Jan; 14(1).

Tan E, Debajyoti R, Sharma S, Bhatia RD, Barbier S, Khoo J et al. Prevalence and Risk Factors of Renal Artery Stenosis in South Asian Patients with Type 2 Diabetes Using Renal Angiography. Indian Journal of Nephrology. 2014 Jan; 24(1): 68-9. doi: 10.4103/0971-4065.125143. DOI: https://doi.org/10.4103/0971-4065.125143

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Published

2026-04-30
CITATION
DOI: 10.54393/pjhs.v7i4.3763
Published: 2026-04-30

How to Cite

Din, Z. U., Ishaq, S., Ibrahim, J., Khan, S. D., Gul, H., Noor, S., & Khan, W. H. (2026). Incidental Renal Artery Stenosis amongst a Cohort of Hypertensive Patients Undergoing Coronary Angiography: An Analytical Cross-Sectional Study : Incidental Renal Artery Stenosis: Hypertensive Patients Undergoing Coronary Angiography. Pakistan Journal of Health Sciences, 7(4), 27–32. https://doi.org/10.54393/pjhs.v7i4.3763

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