Prevalence of Spontaneous Bacterial Peritonitis in Patients with Liver Cirrhosis with Ascites

Prevalence of Spontaneous Bacterial Peritonitis in Liver Cirrhosis with Ascites

Authors

  • Muhammad Adil Choudary Department of Gastroenterology, District Head Quarter Hospital, Gujranwala, Pakistan
  • Najam-us-sehar Saeed Department of Gastroenterology, District Head Quarter Hospital, Gujranwala, Pakistan
  • Salman Javed Department of Gastroenterology, Services Institute of Medical Sciences, Lahore, Pakistan
  • Muhammad Nabeel shafqat Department of Gastroenterology, District Head Quarter Hospital, Gujranwala, Pakistan
  • Sheroze Mumtaz Department of Gastroenterology, District Head Quarter Hospital, Gujranwala, Pakistan
  • Hafsa Farooq Department of Gastroenterology, Services Institute of Medical Sciences, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v3i06.361

Keywords:

Child Turcotte Pugh, cirrhosis, Spontaneous bacterial peritonitis

Abstract

Bacterial infections are considered a significant challenge in patients with cirrhosis. They account for 25%–46% of hospitalizations in patients with cirrhosis due to significant decompensation processes and are associated with substantial morbidity and mortality. Objective: To determine the prevalence of SBP in patients with liver cirrhosis and ascites. Methods: According to the inclusion criteria, 199 patients with cirrhosis and ascites were included in the study, regardless of the cause of cirrhosis (alcohol, HCV, HBV, autoimmune, cryptogenic, etc.). SBP frequency in cirrhotic with ascites was documented using a proforma. All data was entered into a proforma template. All patients were treated with respect to evaluate the prevalence of SBP in cirrhosis with ascites patients. The study was conducted at the Department of Medicine at Gujranwala Medical College-District Headquarters Hospital in Gujranwala. Total duration of study was six months. Results: In terms of patient age distribution, 49 patients (24.6%) were between the ages of 30 and 45, 150 patients (75.4%) were between the ages of 46 and 60. The cohort's patients had an average age of 51.21± 6.61. 42.7% of the population (n = 85) was female, while 57.3% (n = 114) was male. SBP frequency was 32.2% in cirrhosis with ascites individuals. Conclusions: We concluded that 32.2% of participants with cirrhosis with ascites also had SBP. The mortality rate in these patients will be decreased by early diagnosis and treatment. Any patient with cirrhosis and ascites should have SBP ruled out.

References

Bashyam M, Lepore M, Harbord M. Management of cirrhotic ascites. British Journal of Hospital Medicine (London). 2015 Feb;76(2):C28-32. doi: 10.12968/hmed.2015.76.2.C28.

Nusrat S, Khan MS, Fazili J, Madhoun MF. Cirrhosis and its complications: evidence based treatment. World Journal of Gastroenterology. 2014 May; 20(18): 5442-60. doi: 10.3748/wjg.v20.i18.5442.

Sudulagunta SR, Sodalagunta MB, Raja SK, Khorram H, Sepehrar M, Noroozpour Z. Clinical profile and complications of paracentesis in refractory ascites patients with cirrhosis. Gastroenterology Research. 2015 Aug; 8(3-4): 228. doi: 10.14740/gr661w.

Orman ES, Hayashi PH, Bataller R, Barritt AS. Paracentesis is associated with reduced mortality in patients hospitalized with cirrhosis and ascites. Clinical Gastroenterology and Hepatology. 2014 Mar;12(3):496-503. doi: 10.1016/j.cgh.2013.08.025.

Oladimeji AA, Temi AP, Adekunle AE, Taiwo RH, Ayokunle DS. Prevalence of spontaneous bacterial peritonitis in liver cirrhosis with ascites. Pan African Medical Journal. 2013 Dec; 15(1): 1-7. doi: 10.11604/pamj.2013.15.128.2702.

Paul K, Kaur J, Kazal HL. To study the incidence, predictive factors and clinical outcome of spontaneous bacterial peritonitis in patients of cirrhosis with ascites. Journal of clinical and diagnostic research: JCDR. 2015 Jul; 9(7): OC09. doi: 10.7860/JCDR/2015/14855.6191.

Căruntu FA, Benea L. Spontaneous bacterial peritonitis: pathogenesis, diagnosis, treatment. Journal of Gastrointestinal and Liver Diseases. 2006 Mar; 15(1): 51-6.

Wiest R, Krag A, Gerbes A. Spontaneous bacterial peritonitis: recent guidelines and beyond. Gut. 2012 Feb; 61(2): 297-310. doi: 10.1136/gutjnl-2011-300779.

European Association for The Study of the Liver. EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. Journal of hepatology. 2010 Sep;53(3):397-417. doi: 10.1016/j.jhep.2010.05.004.

Lutz P, Nischalke HD, Strassburg CP, Spengler U. Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver. World journal of hepatology. 2015 Mar; 7(3): 304. doi: 10.4254/wjh.v7.i3.304.

Nobre SR, Cabral JE, Gomes JJ, Leitão MC. In-hospital mortality in spontaneous bacterial peritonitis: a new predictive model. European journal of gastroenterology &hepatology. 2008 Dec; 20(12): 1176-81. doi: 10.1097/MEG.0b013e32830607a2.

Lefkowitch JH. Anatomy and function. Sherlock's Diseases of the Liver and Biliary System. 2018 Jun; 25:1-9. doi: 10.1002/9781119237662.ch1.

European Association for The Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. Journal of hepatology. 2018 Aug; 69(2): 406-60. doi: 10.1016/j.jhep.2018.03.024.

Amarapurkar DN, Viswanathan N, Parikh SS, Kalro RH, Desai HG. Prevalence of spontaneous bacterial peritonitis. The Journal of the Association of Physicians of India. 1992 Apr; 40(4): 236-8.

Balan G, Trifan A, Botezatu D, Anton C. Spontaneous bacterial peritonitis: a severe complication of liver cirrhosis. Revista Medico-chirurgicala a Societatii de Medici siNaturalisti din Iasi. 2011 Jan; 115(1): 38-44.

Ding X, Yu Y, Chen M, Wang C, Kang Y, Lou J. Causative agents and outcome of spontaneous bacterial peritonitis in cirrhotic patients: community-acquired versus nosocomial infections. BMC infectious diseases. 2019 Dec; 19(1): 1-8. doi: 10.1186/s12879-019-4102-4.

Zhao R, Lu J, Shi Y, Zhao H, Xu K, Sheng J. Current management of refractory ascites in patients with cirrhosis. Journal of International Medical Research. 2018 Mar;46(3):1138-45. doi: 10.1177/030006051773523.

Ahmed Z, Ahmed U, Walayat S, Ren J, Martin DK, Moole H,et al. Liver function tests in identifying patients with liver disease. Clinical and experimental gastroenterology. 2018;11:301-7.doi: 10.2147/CEG.S160537.

Piano S, Fasolato S, Salinas F, Romano A, Tonon M, Morando F, et al. The empirical antibiotic treatment of nosocomial spontaneous bacterial peritonitis: results of a randomized, controlled clinical trial. Hepatology. 2016 Apr; 63(4): 1299-309. doi: 10.1002/hep.27941.

Shizuma T. Spontaneous bacterial and fungal peritonitis in patients with liver cirrhosis: A literature review. World journal of hepatology. 2018 Feb; 10(2): 254. doi: 10.4254/wjh.v10.i2.254.

Downloads

Published

2022-11-30
CITATION
DOI: 10.54393/pjhs.v3i06.361
Published: 2022-11-30

How to Cite

Adil Choudary, M. ., Saeed, N.- us- sehar ., Javed, S., Nabeel shafqat, M. ., Mumtaz, S. ., & Farooq, H. . (2022). Prevalence of Spontaneous Bacterial Peritonitis in Patients with Liver Cirrhosis with Ascites: Prevalence of Spontaneous Bacterial Peritonitis in Liver Cirrhosis with Ascites. Pakistan Journal of Health Sciences, 3(06), 189–192. https://doi.org/10.54393/pjhs.v3i06.361

Issue

Section

Original Article

Plaudit

Most read articles by the same author(s)