Evaluation of Factors Leading to the Development of Acute Pancreatitis at Tertiary Care Hospital, Karachi: Evaluation of Factors Leading to the Development of Acute Pancreatitis

Muneeba Asif; Faizan Tariq; Faraz Tarique; Abdul Wadood Shah; Rukhsana Soomro; Aliya Zaman

doi:10.54393/pjhs.v6i7.3347

Authors

Muneeba Asif Department of Medicine, Muhammad Medical and Dental College, Ibn e Sina University, Mirpurkhas, Pakistan
Faizan Tariq Department of Internal Medicine, Murshid Hospital and Health Care Centre, Karachi, Pakistan
Faraz Tarique Department of Infectious Diseases, Shaheed Mohtarma Benazir Bhutto, Institute of Trauma, Karachi, Pakistan
Abdul Wadood Shah Department of Community Medicine, Bilawal Medical College, Jamshoro, Pakistan
Rukhsana Soomro Department of Physiology, Suleman Roshan Medical College, Tando Adam, Pakistan
Aliya Zaman Department of Pathology, Muhammad Medical and Dental College, Ibn e Sina University, Mirpurkhas, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i7.3347

Keywords:

Cholelithiasis, Alcohol, Post-ERCP, Hypertriglyceridemia, IgG4-Mediated Pancreatitis

Abstract

Acute pancreatitis (AP) involves pancreatic inflammation that may extend to surrounding tissues. Clinical outcomes can be predicted through assessment of disease-specific prognostic markers. Objectives: To evaluate the prevalence of etiological factors for AP among patients at a tertiary healthcare center in Karachi. Methods: A descriptive cross-sectional design, this six-month study was conducted in the Medicine Department of Civil Hospital, Karachi, from 06-08-2022 to 05-02-2023. Participants were selected through convenience sampling (a non-probability approach). Data processing was done by SPSS version 26.0. Chi-square test was applied by taking a p-value of ≤ 0.05, which is significant. Results: The research cohort comprised 135 eligible participants with a mean age of 46.71 ± 6.82 years. Gender distribution showed 55 male patients (40.7%) and 80 female patients (59.3%). Out of the 135 patients, 43.7% had cholelithiasis, 11.1% had alcohol induced pancreatitis, 17.8% had post-ERCP pancreatitis, 14.8% had hypertriglyceridemia, and 10.4% had IgG4-mediated pancreatitis. Conclusions: Acute pancreatitis is a multi-factorial pathology of different severity and outcomes. Gallstones were found to be the most prevalent cause of the condition.

References

Acute pancreatitis (AP) involves pancreatic inflammation that may extend to surrounding tissues. Clinical outcomes can be predicted through assessment of disease-specific prognostic markers. Objectives: To evaluate the prevalence of etiological factors for AP among patients at a tertiary healthcare center in Karachi. Methods: A descriptive cross-sectional design, this six-month study was conducted in the Medicine Department of Civil Hospital, Karachi, from 06-08-2022 to 05-02-2023. Participants were selected through convenience sampling (a non-probability approach). Data processing was done by SPSS version 26.0. Chi-square test was applied by taking a p-value of ≤ 0.05, which is significant. Results: The research cohort comprised 135 eligible participants with a mean age of 46.71 ± 6.82 years. Gender distribution showed 55 male patients (40.7%) and 80 female patients (59.3%). Out of the 135 patients, 43.7% had cholelithiasis, 11.1% had alcohol induced pancreatitis, 17.8% had post-ERCP pancreatitis, 14.8% had hypertriglyceridemia, and 10.4% had IgG4-mediated pancreatitis. Conclusions: Acute pancreatitis is a multi-factorial pathology of different severity and outcomes. Gallstones were found to be the most prevalent cause of the condition.