Malignant Transformation of the Mature Cystic Teratoma of the Ovary
Mature Cystic Teratoma of the Ovary
DOI:
https://doi.org/10.54393/pjhs.v3i05.271Keywords:
Malignant transformation, Cystic teratoma, OvaryAbstract
The mature cystic teratoma of ovary is most prevalent type of neoplasm of ovarian germ cells. It accounts for the almost 20% of the neoplasm. Objective: To find the malignant transformation of mature cystic teratoma of ovary. Methods: The study was conducted on the 28 patients who visited Cheikh Zayed Hospital Mauritania for the duration of six months from July 2018 to December 2018 and patients who underwent surgery related to ovarian cancer. All the patients underwent tumor marker tests to see the level of cancer antigen in their serum. The level of serum SCC antigen was also tested in all patients before carrying out any surgery. The level of CA-19-9 was also measured. CEA level to check the carcinoembryonic antigen was also carried out. Results: Among these 28, there were 15 patients that had malignant transformation from MCT. The age of patients was ranging from 28 to 74 years. The median age was 50 years. There were 9 patients that were on a post-menopausal state. There were 4 patients that were reported as nulliparous, the remaining were parous. Almost all the patients were presented with symptoms like lower abdominal pain and feeling of palpable mass in the lower abdomen. Conclusions: Malignant transformation in case of MCT is rare but it has poor prognosis. Its quick detection and proper treatment is very important. The use of surgical operation along with adjuvant treatment and chemotherapy have role in controlling the malignancy
References
Park JY, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH. Malignant transformation of mature cystic teratoma of the ovary: experience at a single institution. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2008 Dec; 141(2):173-8. doi: 10.1016/j.ejogrb.2008.07.032
Bal A, Mohan H, Singh SB, Sehgal A. Malignant transformation in mature cystic teratoma of the ovary: report of five cases and review of the literature. Archives of Gynecology and Obstetrics. 2007 Mar; 275(3):179-82. doi: 10.1007/s00404-006-0244-x
Yamanaka Y, Tateiwa Y, Miyamoto H, Umemoto Y, Takeuchi Y, Katayama K, et al. Preoperative diagnosis of malignant transformation in mature cystic teratoma of the ovary. European journal of gynaecological oncology. 2005 Jan; 26(4):391-2. doi: 10.1016/s0090-8258(03)00259-2
Li C, Zhang Q, Zhang S, Dong R, Sun C, Qiu C, et al. Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review. BMC cancer. 2019 Dec; 19(1):1-2. doi: 10.22541/au.161452575.51616620/v1
Hackethal A, Brueggmann D, Bohlmann MK, Franke FE, Tinneberg HR, Münstedt K. Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data. The lancet oncology. 2008 Dec; 9(12):1173-80. doi: 10.1016/s1470-2045(08)70306-1
Ulker V, Numanoglu C, Akbayir O, Akyol A, Tuncel A, Akca A, et al. Malignant transformation arising from mature cystic teratoma of the ovary: a report of six cases. Journal of Obstetrics and Gynaecology Research. 2012 May; 38(5):849-53. doi: 10.1111/j.1447-0756.2011.01797.x
Sakuma M, Otsuki T, Yoshinaga K, Utsunomiya H, Nagase S, Takano T, et al. Malignant transformation arising from mature cystic teratoma of the ovary: a retrospective study of 20 cases. International Journal of Gynecologic Cancer. 2010 Jun; 20(5). doi: 10.1111/IGC.0b013e3181daaf1d
Rim SY, Kim SM, Choi HS. Malignant transformation of ovarian mature cystic teratoma. International Journal of Gynecologic Cancer. 2006 Jan; 16(1). doi: 10.1136/ijgc-00009577-200601000-00023
Yoshioka T and Tanaka T. Immunohistochemical and molecular studies on malignant transformation in mature cystic teratoma of the ovary. Journal of Obstetrics and Gynaecology Research. 1998 Apr; 24(2):83-90. doi: 10.1111/j.1447-0756.1998.tb00057.x
Wu RT, Torng PL, Chang DY, Chen CK, Chen RJ, Lin MC, et al. Mature cystic teratoma of the ovary: a clinicopathologic study of 283 cases. Chinese Medical Journal. 1996 Oct; 58(4):269-74.
Oranratanaphan S and Khemapech N. Characteristics and treatment outcomes of patients with malignant transformation arising from mature cystic teratoma of the ovary: experience at a single institution. Asian Pacific Journal of Cancer Prevention. 2013; 14(8):4693-7. doi: 10.7314/APJCP.2013.14.8.4693
Dos Santos L, Mok E, Iasonos A, Park K, Soslow RA, Aghajanian C, et al. Squamous cell carcinoma arising in mature cystic teratoma of the ovary: a case series and review of the literature. Gynecologic Oncology. 2007 May; 105(2):321-4. doi: 10.1016/j.ygyno.2006.12.008
Koc S, Tapisiz OL, Turan T, Ocalan R, Ozfuttu A, Boran N, et al. Malignant transformation of mature cystic teratoma of the ovary: a case series. Journal of experimental therapeutics & oncology. 2015 Jan; 11(1).
Hosokawa T, Sato Y, Seki T, Maebara M, Ito K, Kuribayashi S. Malignant transformation of a mature cystic teratoma of the ovary with rupture. Japanese Journal of Radiology. 2010 Jun; 28(5):372-5. doi: 10.1007/s11604-010-0434-0
Park CH, Jung MH, Ji YI. Risk factors for malignant transformation of mature cystic teratoma. Obstetrics and gynecology science. 2015 Nov 16; 58(6):475-80. doi: 10.5468/ogs.2015.58.6.475
Lai PF, Hsieh SC, Chien JC, Fang CL, Chan WP, Yu C. Malignant transformation of an ovarian mature cystic teratoma: computed tomography findings. Archives of Gynecology and Obstetrics. 2005 Apr; 271(4):355-7. doi: 10.1007/s00404-004-0676-0
Chen RJ, Chen KY, Chang TC, Sheu BC, Chow SN, Huang SC. Prognosis and treatment of squamous cell carcinoma from a mature cystic teratoma of the ovary. Journal of the Formosan Medical Association. 2008 Nov; 107(11):857-68. doi: 10.1016/S0929-6646(08)60202-8
Kawai M, Kano T, Kikkawa F, Morikawa Y, Oguchi H, Nakashima N, et al. Seven tumor markers in benign and malignant germ cell tumors of the ovary. Gynecologic oncology. 1992 Jun; 45(3):248-53. doi: 10.1016/0090-8258(92)90299-X
Lim SC, Choi SJ, Sun CH. A case of small cell carcinoma arising in a mature cystic teratoma of the ovary. Pathology international. 1998 Oct; 48(10):834-9. doi: 10.1111/j.1440-1827.1998.tb03846.x
Park SB, Cho KS, Kim JK. CT findings of mature cystic teratoma with malignant transformation: comparison with mature cystic teratoma. Clinical imaging. 2011 Jul; 35(4):294-300. doi: 10.1016/j.clinimag.2010.08.016
Levine DA, Villella JA, Poynor EA, Soslow RA. Gastrointestinal adenocarcinoma arising in a mature cystic teratoma of the ovary. Gynecologic oncology. 2004 Aug; 94(2):597-9. doi: 10.1016/j.ygyno.2004.05.045
Contreras AL and Malpica A. Angiosarcoma arising in mature cystic teratoma of the ovary: a case report and review of the literature. International Journal of Gynecological Pathology. 2009 Sep; 28(5):453-7. doi: 10.1097/pgp.0b013e31819d4574
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Pakistan Journal of Health Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments
