Antimicrobial Activity of Azithromycin versus Ciprofloxacin in the Treatment of Uncomplicated Enteric Fever in Children and Adolescents: Preclinical Trial: Antimicrobial Activity of Azithromycin Versus Ciprofloxacin for Uncomplicated Enteric Fever

Zona Irfan; Ali Nawaz Bijarani; Yousra Muhammad Pervaiz; Fauzia Perveen; Shahid Pervez Shaikh; Humaira Arif

doi:10.54393/pjhs.v5i12.2215

Authors

Zona Irfan Department of Pathology, Fazaia Ruth Pfau Medical College, Karachi, Pakistan
Ali Nawaz Bijarani Department of Pharmacology, Shaheed Mohtarma Benazir Bhutto Medical College Lyari, Karachi, Pakistan
Yousra Muhammad Pervaiz Department of Microbiology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
Fauzia Perveen Department of Biochemistry, Liaquat College of Medicine and Dentistry, Karachi, Pakistan
Shahid Pervez Shaikh Department of Anatomy, Baqai Medical University, Karachi, Pakistan
Humaira Arif Department of Pharmacology and Therapeutics, Baqai Dental College, Baqai Medical University, Karachi, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i12.2215

Keywords:

Salmonella Typhi, Antimicrobial Susceptibility Pattern, Azithromycin, Ciprofloxacin

Abstract

Typhoid fever, or enteric fever, is an infectious disorder particularly prevalent in Pakistan. Salmonella Typhi is the common and occasionally fatal cause of enteric fever. Objective: To compare the antimicrobial activity of Azithromycin versus Ciprofloxacin in the treatment of uncomplicated enteric fever in children. Methods: This was a comparative cross-sectional study conducted at the Department of Microbiology at Ziauddin University Hospital, Karachi. It lasted six months, from 3 January 2020 to 2 July 2020. There were 152 blood samples in all. According to Clinical and Laboratory Standards Institute guidelines, the antibiotic susceptibility of the isolates was assessed using the Modified Kirby Bauer disc diffusion method on Muller-Hinton agar. Results: When treating typhoid fever in children with simple enteric fever, the susceptibility pattern of Salmonella Typhi revealed that azithromycin was more efficient than ciprofloxacin in preventing the growth of Salmonella Typhi across all samples. Ciprofloxacin showed resistant bacteria. Conclusion: Azithromycin seems to be more clinically effective than ciprofloxacin in treating children's simple enteric fever when treating typhoid fever.

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